4N9I

Crystal Structure of Transcription regulation protein CRP complexed with cGMP

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000166	molecular_function	nucleotide binding
A	0003677	molecular_function	DNA binding
A	0003700	molecular_function	DNA-binding transcription factor activity
A	0005829	cellular_component	cytosol
A	0006355	biological_process	regulation of DNA-templated transcription
A	0030552	molecular_function	cAMP binding
A	0032993	cellular_component	protein-DNA complex
A	0043565	molecular_function	sequence-specific DNA binding
A	0045893	biological_process	positive regulation of DNA-templated transcription
B	0000166	molecular_function	nucleotide binding
B	0003677	molecular_function	DNA binding
B	0003700	molecular_function	DNA-binding transcription factor activity
B	0005829	cellular_component	cytosol
B	0006355	biological_process	regulation of DNA-templated transcription
B	0030552	molecular_function	cAMP binding
B	0032993	cellular_component	protein-DNA complex
B	0043565	molecular_function	sequence-specific DNA binding
B	0045893	biological_process	positive regulation of DNA-templated transcription
C	0000166	molecular_function	nucleotide binding
C	0003677	molecular_function	DNA binding
C	0003700	molecular_function	DNA-binding transcription factor activity
C	0005829	cellular_component	cytosol
C	0006355	biological_process	regulation of DNA-templated transcription
C	0030552	molecular_function	cAMP binding
C	0032993	cellular_component	protein-DNA complex
C	0043565	molecular_function	sequence-specific DNA binding
C	0045893	biological_process	positive regulation of DNA-templated transcription
D	0000166	molecular_function	nucleotide binding
D	0003677	molecular_function	DNA binding
D	0003700	molecular_function	DNA-binding transcription factor activity
D	0005829	cellular_component	cytosol
D	0006355	biological_process	regulation of DNA-templated transcription
D	0030552	molecular_function	cAMP binding
D	0032993	cellular_component	protein-DNA complex
D	0043565	molecular_function	sequence-specific DNA binding
D	0045893	biological_process	positive regulation of DNA-templated transcription

Functional Information from PDB Data

site_id	AC1
Number of Residues	13
Details	BINDING SITE FOR RESIDUE PCG A 301

Chain	Residue
A	VAL49
A	HOH472
B	GLN125
B	LYS130
B	HOH402
A	SER62
A	GLY71
A	GLU72
A	ARG82
A	SER83
A	HOH405
A	HOH416
A	HOH468

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site_id	AC2
Number of Residues	9
Details	BINDING SITE FOR RESIDUE PCG B 301

Chain	Residue
B	VAL49
B	LEU61
B	GLY71
B	GLU72
B	ARG82
B	SER83
B	ARG123
B	HOH433
B	HOH444

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site_id	AC3
Number of Residues	12
Details	BINDING SITE FOR RESIDUE PCG C 301

Chain	Residue
C	VAL49
C	LEU61
C	SER62
C	GLY71
C	GLU72
C	ARG82
C	SER83
C	HOH410
C	HOH421
D	GLN125
D	LYS130
D	HOH401

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site_id	AC4
Number of Residues	10
Details	BINDING SITE FOR RESIDUE PCG D 301

Chain	Residue
D	VAL49
D	LEU61
D	SER62
D	GLY71
D	GLU72
D	ARG82
D	SER83
D	ARG123
D	HOH428
D	HOH438

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Functional Information from PROSITE/UniProt

site_id	PS00042
Number of Residues	24
Details	HTH_CRP_1 Crp-type HTH domain signature. ITRqeIGqIVGcSreTv.GRiLkmL

Chain	Residue	Details
A	ILE167-LEU190

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site_id	PS00888
Number of Residues	17
Details	CNMP_BINDING_1 Cyclic nucleotide-binding domain signature 1. LIhQGEkAEtLYYIvkG

Chain	Residue	Details
A	LEU29-GLY45

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site_id	PS00889
Number of Residues	19
Details	CNMP_BINDING_2 Cyclic nucleotide-binding domain signature 2. IGElGLfeegqe.....RSAwVrA

Chain	Residue	Details
A	ILE70-ALA88

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