4N9I
Crystal Structure of Transcription regulation protein CRP complexed with cGMP
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0003677 | molecular_function | DNA binding |
| A | 0003700 | molecular_function | DNA-binding transcription factor activity |
| A | 0005829 | cellular_component | cytosol |
| A | 0006355 | biological_process | regulation of DNA-templated transcription |
| B | 0003677 | molecular_function | DNA binding |
| B | 0003700 | molecular_function | DNA-binding transcription factor activity |
| B | 0005829 | cellular_component | cytosol |
| B | 0006355 | biological_process | regulation of DNA-templated transcription |
| C | 0003677 | molecular_function | DNA binding |
| C | 0003700 | molecular_function | DNA-binding transcription factor activity |
| C | 0005829 | cellular_component | cytosol |
| C | 0006355 | biological_process | regulation of DNA-templated transcription |
| D | 0003677 | molecular_function | DNA binding |
| D | 0003700 | molecular_function | DNA-binding transcription factor activity |
| D | 0005829 | cellular_component | cytosol |
| D | 0006355 | biological_process | regulation of DNA-templated transcription |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 13 |
| Details | BINDING SITE FOR RESIDUE PCG A 301 |
| Chain | Residue |
| A | VAL49 |
| A | HOH472 |
| B | GLN125 |
| B | LYS130 |
| B | HOH402 |
| A | SER62 |
| A | GLY71 |
| A | GLU72 |
| A | ARG82 |
| A | SER83 |
| A | HOH405 |
| A | HOH416 |
| A | HOH468 |
| site_id | AC2 |
| Number of Residues | 9 |
| Details | BINDING SITE FOR RESIDUE PCG B 301 |
| Chain | Residue |
| B | VAL49 |
| B | LEU61 |
| B | GLY71 |
| B | GLU72 |
| B | ARG82 |
| B | SER83 |
| B | ARG123 |
| B | HOH433 |
| B | HOH444 |
| site_id | AC3 |
| Number of Residues | 12 |
| Details | BINDING SITE FOR RESIDUE PCG C 301 |
| Chain | Residue |
| C | VAL49 |
| C | LEU61 |
| C | SER62 |
| C | GLY71 |
| C | GLU72 |
| C | ARG82 |
| C | SER83 |
| C | HOH410 |
| C | HOH421 |
| D | GLN125 |
| D | LYS130 |
| D | HOH401 |
| site_id | AC4 |
| Number of Residues | 10 |
| Details | BINDING SITE FOR RESIDUE PCG D 301 |
| Chain | Residue |
| D | VAL49 |
| D | LEU61 |
| D | SER62 |
| D | GLY71 |
| D | GLU72 |
| D | ARG82 |
| D | SER83 |
| D | ARG123 |
| D | HOH428 |
| D | HOH438 |
Functional Information from PROSITE/UniProt
| site_id | PS00042 |
| Number of Residues | 24 |
| Details | HTH_CRP_1 Crp-type HTH domain signature. ITRqeIGqIVGcSreTv.GRiLkmL |
| Chain | Residue | Details |
| A | ILE167-LEU190 |
| site_id | PS00888 |
| Number of Residues | 17 |
| Details | CNMP_BINDING_1 Cyclic nucleotide-binding domain signature 1. LIhQGEkAEtLYYIvkG |
| Chain | Residue | Details |
| A | LEU29-GLY45 |
| site_id | PS00889 |
| Number of Residues | 19 |
| Details | CNMP_BINDING_2 Cyclic nucleotide-binding domain signature 2. IGElGLfeegqe.....RSAwVrA |
| Chain | Residue | Details |
| A | ILE70-ALA88 |
