4N95
E. coli sliding clamp in complex with 5-chloroindoline-2,3-dione
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0003677 | molecular_function | DNA binding |
| A | 0003887 | molecular_function | DNA-directed DNA polymerase activity |
| A | 0005515 | molecular_function | protein binding |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0005829 | cellular_component | cytosol |
| A | 0006260 | biological_process | DNA replication |
| A | 0006261 | biological_process | DNA-templated DNA replication |
| A | 0006271 | biological_process | DNA strand elongation involved in DNA replication |
| A | 0006974 | biological_process | DNA damage response |
| A | 0008408 | molecular_function | 3'-5' exonuclease activity |
| A | 0009360 | cellular_component | DNA polymerase III complex |
| A | 0030174 | biological_process | regulation of DNA-templated DNA replication initiation |
| A | 0030894 | cellular_component | replisome |
| A | 0032297 | biological_process | negative regulation of DNA-templated DNA replication initiation |
| A | 0042276 | biological_process | error-prone translesion synthesis |
| A | 0042802 | molecular_function | identical protein binding |
| A | 0042803 | molecular_function | protein homodimerization activity |
| A | 0044787 | biological_process | bacterial-type DNA replication |
| A | 1990078 | cellular_component | replication inhibiting complex |
| A | 1990085 | cellular_component | Hda-beta clamp complex |
| B | 0003677 | molecular_function | DNA binding |
| B | 0003887 | molecular_function | DNA-directed DNA polymerase activity |
| B | 0005515 | molecular_function | protein binding |
| B | 0005737 | cellular_component | cytoplasm |
| B | 0005829 | cellular_component | cytosol |
| B | 0006260 | biological_process | DNA replication |
| B | 0006261 | biological_process | DNA-templated DNA replication |
| B | 0006271 | biological_process | DNA strand elongation involved in DNA replication |
| B | 0006974 | biological_process | DNA damage response |
| B | 0008408 | molecular_function | 3'-5' exonuclease activity |
| B | 0009360 | cellular_component | DNA polymerase III complex |
| B | 0030174 | biological_process | regulation of DNA-templated DNA replication initiation |
| B | 0030894 | cellular_component | replisome |
| B | 0032297 | biological_process | negative regulation of DNA-templated DNA replication initiation |
| B | 0042276 | biological_process | error-prone translesion synthesis |
| B | 0042802 | molecular_function | identical protein binding |
| B | 0042803 | molecular_function | protein homodimerization activity |
| B | 0044787 | biological_process | bacterial-type DNA replication |
| B | 1990078 | cellular_component | replication inhibiting complex |
| B | 1990085 | cellular_component | Hda-beta clamp complex |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 10 |
| Details | BINDING SITE FOR RESIDUE PG4 B 401 |
| Chain | Residue |
| A | ASP121 |
| B | GLY66 |
| A | TRP122 |
| A | GLN123 |
| A | SER124 |
| A | GLN217 |
| A | ARG224 |
| A | HOH644 |
| B | VAL37 |
| B | ALA38 |
| site_id | AC2 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE PG4 B 402 |
| Chain | Residue |
| B | SER18 |
| B | LEU21 |
| B | ARG73 |
| B | PHE76 |
| B | ARG80 |
| B | HOH746 |
| site_id | AC3 |
| Number of Residues | 8 |
| Details | BINDING SITE FOR RESIDUE PEG B 403 |
| Chain | Residue |
| A | HOH691 |
| B | ASP121 |
| B | TRP122 |
| B | GLN123 |
| B | SER124 |
| B | GLN217 |
| B | ARG224 |
| B | HOH546 |
| site_id | AC4 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE PEG B 404 |
| Chain | Residue |
| B | GLU87 |
| B | ALA89 |
| B | ARG100 |
| B | SER101 |
| B | GLY102 |
| B | GLU287 |
| B | HOH760 |
| site_id | AC5 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE 2HQ A 401 |
| Chain | Residue |
| A | THR172 |
| A | GLY174 |
| A | HIS175 |
| A | ARG176 |
| A | VAL247 |
| A | VAL360 |
| site_id | AC6 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE PEG A 402 |
| Chain | Residue |
| A | SER181 |
| A | GLU350 |
| A | GLN355 |
| A | SER356 |
| site_id | AC7 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE PEG A 403 |
| Chain | Residue |
| A | MET1 |
| A | GLU64 |
| A | PRO65 |
| A | ALA67 |
| B | GLU125 |
| site_id | AC8 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE PEG A 404 |
| Chain | Residue |
| A | ARG105 |
| A | TYR284 |
| A | VAL285 |
| A | GLU314 |
| A | MET315 |
| B | GLU303 |
| B | ILE305 |
| site_id | AC9 |
| Number of Residues | 1 |
| Details | BINDING SITE FOR RESIDUE CL A 405 |
| Chain | Residue |
| A | ALA58 |
| site_id | BC1 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE PGE A 406 |
| Chain | Residue |
| A | ARG246 |
| A | LEU248 |
| A | LYS250 |
| A | SER346 |
| A | HOH561 |
| site_id | BC2 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE CA A 407 |
| Chain | Residue |
| A | GLU95 |
| A | THR110 |
| A | HOH643 |
| A | HOH708 |
| site_id | BC3 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE CA A 408 |
| Chain | Residue |
| A | ASN32 |
| A | PRO71 |
| A | SER109 |
| A | THR110 |
| A | LEU111 |
| B | GLU334 |
| site_id | BC4 |
| Number of Residues | 1 |
| Details | BINDING SITE FOR RESIDUE CA A 409 |
| Chain | Residue |
| A | HIS226 |
| site_id | BC5 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE CA A 410 |
| Chain | Residue |
| A | GLY85 |
| A | GLU87 |
| A | HOH711 |
| B | ASP120 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 6 |
| Details | BINDING: BINDING => ECO:0000305|PubMed:18191219 |
| Chain | Residue | Details |
| B | ARG24 | |
| B | GLN149 | |
| B | TYR153 | |
| A | ARG24 | |
| A | GLN149 | |
| A | TYR153 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 2 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:18191219 |
| Chain | Residue | Details |
| B | ARG73 | |
| A | ARG73 |
