4N8M
Structural polymorphism in the N-terminal oligomerization domain of NPM1
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE CO A 601 |
| Chain | Residue |
| A | ASP28 |
| A | HIS30 |
| site_id | AC2 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE CO B 201 |
| Chain | Residue |
| B | ASP28 |
| B | HIS30 |
| B | HOH355 |
| B | HOH357 |
| B | HOH358 |
| site_id | AC3 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE CO C 201 |
| Chain | Residue |
| C | ASP28 |
| C | HIS30 |
| site_id | AC4 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE CO D 201 |
| Chain | Residue |
| D | ASP28 |
| D | HIS30 |
| site_id | AC5 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE CO E 201 |
| Chain | Residue |
| E | ASP28 |
| E | HIS30 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 10 |
| Details | SITE: Interaction between pentamers => ECO:0000250 |
| Chain | Residue | Details |
| A | ASP55 | |
| E | LYS80 | |
| A | LYS80 | |
| B | ASP55 | |
| B | LYS80 | |
| C | ASP55 | |
| C | LYS80 | |
| D | ASP55 | |
| D | LYS80 | |
| E | ASP55 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 5 |
| Details | MOD_RES: N-acetylmethionine => ECO:0000250|UniProtKB:P06748 |
| Chain | Residue | Details |
| A | MET1 | |
| B | MET1 | |
| C | MET1 | |
| D | MET1 | |
| E | MET1 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 5 |
| Details | MOD_RES: Phosphoserine; by PLK1 and PLK2 => ECO:0000250|UniProtKB:P06748 |
| Chain | Residue | Details |
| A | SER4 | |
| B | SER4 | |
| C | SER4 | |
| D | SER4 | |
| E | SER4 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 10 |
| Details | MOD_RES: Phosphoserine => ECO:0000250|UniProtKB:P06748 |
| Chain | Residue | Details |
| A | SER10 | |
| E | SER43 | |
| A | SER43 | |
| B | SER10 | |
| B | SER43 | |
| C | SER10 | |
| C | SER43 | |
| D | SER10 | |
| D | SER43 | |
| E | SER10 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 5 |
| Details | MOD_RES: N6-acetyllysine; alternate => ECO:0000250|UniProtKB:P06748 |
| Chain | Residue | Details |
| A | LYS32 | |
| B | LYS32 | |
| C | LYS32 | |
| D | LYS32 | |
| E | LYS32 |
| site_id | SWS_FT_FI6 |
| Number of Residues | 5 |
| Details | MOD_RES: Phosphotyrosine => ECO:0007744|PubMed:21183079 |
| Chain | Residue | Details |
| A | TYR67 | |
| B | TYR67 | |
| C | TYR67 | |
| D | TYR67 | |
| E | TYR67 |
| site_id | SWS_FT_FI7 |
| Number of Residues | 5 |
| Details | MOD_RES: Phosphoserine => ECO:0007744|PubMed:19144319, ECO:0007744|PubMed:21183079 |
| Chain | Residue | Details |
| A | SER70 | |
| B | SER70 | |
| C | SER70 | |
| D | SER70 | |
| E | SER70 |
| site_id | SWS_FT_FI8 |
| Number of Residues | 5 |
| Details | MOD_RES: Phosphothreonine => ECO:0007744|PubMed:21183079 |
| Chain | Residue | Details |
| A | THR75 | |
| B | THR75 | |
| C | THR75 | |
| D | THR75 | |
| E | THR75 |
| site_id | SWS_FT_FI9 |
| Number of Residues | 5 |
| Details | MOD_RES: Phosphothreonine => ECO:0000250|UniProtKB:P06748 |
| Chain | Residue | Details |
| A | THR95 | |
| B | THR95 | |
| C | THR95 | |
| D | THR95 | |
| E | THR95 |
| site_id | SWS_FT_FI10 |
| Number of Residues | 5 |
| Details | MOD_RES: Phosphoserine => ECO:0007744|PubMed:16452087, ECO:0007744|PubMed:17242355, ECO:0007744|PubMed:18630941, ECO:0007744|PubMed:19131326, ECO:0007744|PubMed:19144319, ECO:0007744|PubMed:21183079 |
| Chain | Residue | Details |
| A | SER125 | |
| B | SER125 | |
| C | SER125 | |
| D | SER125 | |
| E | SER125 |
| site_id | SWS_FT_FI11 |
| Number of Residues | 5 |
| Details | CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2) => ECO:0000250|UniProtKB:P06748 |
| Chain | Residue | Details |
| A | LYS27 | |
| B | LYS27 | |
| C | LYS27 | |
| D | LYS27 | |
| E | LYS27 |
| site_id | SWS_FT_FI12 |
| Number of Residues | 10 |
| Details | CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternate => ECO:0000250|UniProtKB:P06748 |
| Chain | Residue | Details |
| E | LYS32 | |
| A | LYS32 | |
| B | LYS32 | |
| C | LYS32 | |
| D | LYS32 |
