4N4N
Nitrosomonas europea HAO
Functional Information from GO Data
Chain | GOid | namespace | contents |
A | 0016491 | molecular_function | oxidoreductase activity |
A | 0019331 | biological_process | anaerobic respiration, using ammonium as electron donor |
A | 0020037 | molecular_function | heme binding |
A | 0033740 | molecular_function | hydroxylamine oxidoreductase activity |
A | 0042802 | molecular_function | identical protein binding |
A | 0044222 | cellular_component | anammoxosome |
A | 0046872 | molecular_function | metal ion binding |
A | 0047991 | molecular_function | hydroxylamine oxidase activity |
A | 0070207 | biological_process | protein homotrimerization |
C | 0016491 | molecular_function | oxidoreductase activity |
C | 0019331 | biological_process | anaerobic respiration, using ammonium as electron donor |
C | 0020037 | molecular_function | heme binding |
C | 0033740 | molecular_function | hydroxylamine oxidoreductase activity |
C | 0042802 | molecular_function | identical protein binding |
C | 0044222 | cellular_component | anammoxosome |
C | 0046872 | molecular_function | metal ion binding |
C | 0047991 | molecular_function | hydroxylamine oxidase activity |
C | 0070207 | biological_process | protein homotrimerization |
E | 0016491 | molecular_function | oxidoreductase activity |
E | 0019331 | biological_process | anaerobic respiration, using ammonium as electron donor |
E | 0020037 | molecular_function | heme binding |
E | 0033740 | molecular_function | hydroxylamine oxidoreductase activity |
E | 0042802 | molecular_function | identical protein binding |
E | 0044222 | cellular_component | anammoxosome |
E | 0046872 | molecular_function | metal ion binding |
E | 0047991 | molecular_function | hydroxylamine oxidase activity |
E | 0070207 | biological_process | protein homotrimerization |
Functional Information from PDB Data
site_id | AC1 |
Number of Residues | 21 |
Details | BINDING SITE FOR RESIDUE HEC A 601 |
Chain | Residue |
A | TYR140 |
A | HIS267 |
A | SER277 |
A | ARG278 |
A | ARG319 |
A | LEU320 |
A | MET339 |
A | HIS347 |
A | HEC602 |
A | HEC606 |
A | HOH767 |
A | LYS141 |
A | HOH785 |
A | HOH979 |
A | CYS196 |
A | HIS200 |
A | GLU203 |
A | HIS228 |
A | ASN259 |
A | CYS263 |
A | CYS266 |
site_id | AC2 |
Number of Residues | 19 |
Details | BINDING SITE FOR RESIDUE HEC A 602 |
Chain | Residue |
A | THR122 |
A | HIS123 |
A | LYS141 |
A | LYS144 |
A | LEU145 |
A | VAL148 |
A | VAL167 |
A | CYS196 |
A | CYS199 |
A | HIS200 |
A | CYS263 |
A | HIS267 |
A | PHE272 |
A | SER273 |
A | ALA274 |
A | HEC601 |
A | HEC604 |
A | HOH825 |
A | HOH903 |
site_id | AC3 |
Number of Residues | 17 |
Details | BINDING SITE FOR RESIDUE HEC A 603 |
Chain | Residue |
A | TYR81 |
A | TYR88 |
A | ASP102 |
A | CYS103 |
A | CYS106 |
A | HIS107 |
A | GLU110 |
A | CYS169 |
A | HIS173 |
A | HIS184 |
A | ILE188 |
A | MET190 |
A | HEC604 |
A | HOH838 |
C | SER389 |
C | GLU390 |
C | ARG391 |
site_id | AC4 |
Number of Residues | 23 |
Details | BINDING SITE FOR RESIDUE HEC A 604 |
Chain | Residue |
A | TYR81 |
A | PRO84 |
A | HIS107 |
A | TRP114 |
A | TRP118 |
A | HIS123 |
A | VAL167 |
A | GLY168 |
A | CYS169 |
A | CYS172 |
A | HIS173 |
A | MET190 |
A | PRO191 |
A | LYS262 |
A | ASP264 |
A | ARG269 |
A | HIS270 |
A | PHE272 |
A | HEC602 |
A | HEC603 |
C | HIS388 |
C | SER389 |
C | HOH776 |
site_id | AC5 |
Number of Residues | 20 |
Details | BINDING SITE FOR RESIDUE HEC A 605 |
Chain | Residue |
C | HEC601 |
A | HIS287 |
A | ASN294 |
A | TYR298 |
A | PRO332 |
A | THR333 |
A | CYS334 |
A | CYS337 |
A | HIS338 |
A | THR353 |
A | ARG354 |
A | TRP355 |
A | ALA356 |
A | TRP380 |
A | MET400 |
A | HIS483 |
A | HEC606 |
A | HEC607 |
A | HOH711 |
A | HOH858 |
site_id | AC6 |
Number of Residues | 23 |
Details | BINDING SITE FOR RESIDUE HEC A 606 |
Chain | Residue |
A | PRO226 |
A | SER227 |
A | HIS228 |
A | ASP231 |
A | ALA234 |
A | CYS256 |
A | HIS257 |
A | ASN259 |
A | ASN265 |
A | CYS266 |
A | ALA282 |
A | CYS283 |
A | CYS286 |
A | HIS287 |
A | CYS334 |
A | HIS338 |
A | ILE349 |
A | THR353 |
A | ALA356 |
A | HEC601 |
A | HEC605 |
A | HOH749 |
C | HEC601 |
site_id | AC7 |
Number of Residues | 22 |
Details | BINDING SITE FOR RESIDUE HEC A 607 |
Chain | Residue |
A | HIS303 |
A | LEU306 |
A | PHE324 |
A | ASN330 |
A | ALA331 |
A | PRO332 |
A | THR383 |
A | CYS384 |
A | CYS387 |
A | HIS388 |
A | PHE392 |
A | TYR396 |
A | VAL484 |
A | HEC605 |
A | HOH709 |
A | HOH908 |
E | LYS262 |
E | ASP264 |
E | THR268 |
E | ARG269 |
E | HOH719 |
E | HOH818 |
site_id | AC8 |
Number of Residues | 23 |
Details | BINDING SITE FOR RESIDUE HEC A 608 |
Chain | Residue |
A | THR490 |
A | TYR491 |
A | HOH788 |
A | HOH971 |
E | TRP221 |
E | ARG225 |
E | ALA234 |
E | ASN235 |
E | THR238 |
E | TRP241 |
E | CYS253 |
E | CYS256 |
E | HIS257 |
E | THR285 |
E | CYS286 |
E | HIS287 |
E | HIS292 |
E | ASN357 |
E | PHE452 |
E | HEC606 |
E | HEC607 |
E | HOH713 |
E | HOH779 |
site_id | AC9 |
Number of Residues | 4 |
Details | BINDING SITE FOR RESIDUE K A 609 |
Chain | Residue |
A | ASP312 |
A | HOH916 |
C | ASP312 |
E | ASP312 |
site_id | BC1 |
Number of Residues | 24 |
Details | BINDING SITE FOR RESIDUE HEC C 601 |
Chain | Residue |
A | TRP221 |
A | ARG225 |
A | ALA234 |
A | ASN235 |
A | THR238 |
A | TRP241 |
A | GLY252 |
A | CYS253 |
A | CYS256 |
A | HIS257 |
A | THR285 |
A | CYS286 |
A | HIS287 |
A | HIS292 |
A | ASN357 |
A | PHE452 |
A | HEC605 |
A | HEC606 |
A | HOH775 |
A | HOH968 |
C | THR490 |
C | TYR491 |
C | HOH704 |
C | HOH851 |
site_id | BC2 |
Number of Residues | 21 |
Details | BINDING SITE FOR RESIDUE HEC C 602 |
Chain | Residue |
C | TYR140 |
C | LYS141 |
C | CYS196 |
C | HIS200 |
C | GLU203 |
C | HIS228 |
C | ASN259 |
C | CYS263 |
C | CYS266 |
C | HIS267 |
C | SER277 |
C | ARG278 |
C | ARG319 |
C | LEU320 |
C | MET339 |
C | HIS347 |
C | HEC603 |
C | HEC607 |
C | HOH710 |
C | HOH770 |
C | HOH873 |
site_id | BC3 |
Number of Residues | 19 |
Details | BINDING SITE FOR RESIDUE HEC C 603 |
Chain | Residue |
C | THR122 |
C | HIS123 |
C | LYS141 |
C | LYS144 |
C | LEU145 |
C | VAL167 |
C | VAL176 |
C | CYS196 |
C | CYS199 |
C | HIS200 |
C | CYS263 |
C | HIS267 |
C | PHE272 |
C | SER273 |
C | ALA274 |
C | HEC602 |
C | HEC605 |
C | HOH798 |
C | HOH824 |
site_id | BC4 |
Number of Residues | 20 |
Details | BINDING SITE FOR RESIDUE HEC C 604 |
Chain | Residue |
A | LYS161 |
C | TYR81 |
C | TYR88 |
C | PRO94 |
C | ASP102 |
C | CYS103 |
C | CYS106 |
C | HIS107 |
C | GLU110 |
C | CYS169 |
C | HIS173 |
C | HIS184 |
C | ILE188 |
C | MET190 |
C | HEC605 |
C | HOH778 |
C | HOH817 |
E | SER389 |
E | GLU390 |
E | ARG391 |
site_id | BC5 |
Number of Residues | 22 |
Details | BINDING SITE FOR RESIDUE HEC C 605 |
Chain | Residue |
C | TYR81 |
C | PRO84 |
C | HIS107 |
C | TRP114 |
C | HIS123 |
C | VAL167 |
C | GLY168 |
C | CYS169 |
C | CYS172 |
C | HIS173 |
C | MET190 |
C | PRO191 |
C | LYS262 |
C | ASP264 |
C | ARG269 |
C | HIS270 |
C | PHE272 |
C | HEC603 |
C | HEC604 |
E | HIS388 |
E | SER389 |
E | HOH757 |
site_id | BC6 |
Number of Residues | 21 |
Details | BINDING SITE FOR RESIDUE HEC C 606 |
Chain | Residue |
C | HIS287 |
C | ASN294 |
C | TYR298 |
C | PRO332 |
C | THR333 |
C | CYS334 |
C | CYS337 |
C | HIS338 |
C | THR353 |
C | ARG354 |
C | TRP355 |
C | ALA356 |
C | TRP380 |
C | MET400 |
C | ALA482 |
C | HIS483 |
C | HEC607 |
C | HEC608 |
C | HOH702 |
C | HOH840 |
E | HEC601 |
site_id | BC7 |
Number of Residues | 22 |
Details | BINDING SITE FOR RESIDUE HEC C 607 |
Chain | Residue |
C | PRO226 |
C | SER227 |
C | HIS228 |
C | ASP231 |
C | ALA234 |
C | CYS256 |
C | HIS257 |
C | ASN259 |
C | ASN265 |
C | CYS266 |
C | ALA282 |
C | CYS283 |
C | CYS286 |
C | HIS287 |
C | CYS334 |
C | ILE349 |
C | THR353 |
C | ALA356 |
C | HEC602 |
C | HEC606 |
C | HOH857 |
E | HEC601 |
site_id | BC8 |
Number of Residues | 19 |
Details | BINDING SITE FOR RESIDUE HEC C 608 |
Chain | Residue |
A | LYS262 |
A | ASP264 |
A | THR268 |
A | ARG269 |
A | HOH808 |
C | HIS303 |
C | PHE324 |
C | ASN330 |
C | PRO332 |
C | THR383 |
C | CYS384 |
C | CYS387 |
C | HIS388 |
C | PHE392 |
C | TYR396 |
C | VAL484 |
C | HEC606 |
C | HOH776 |
C | HOH812 |
site_id | BC9 |
Number of Residues | 23 |
Details | BINDING SITE FOR RESIDUE HEC E 601 |
Chain | Residue |
C | TRP221 |
C | ARG225 |
C | ALA234 |
C | ASN235 |
C | THR238 |
C | GLY252 |
C | CYS253 |
C | CYS256 |
C | HIS257 |
C | THR285 |
C | CYS286 |
C | HIS287 |
C | HIS292 |
C | ASN357 |
C | PHE452 |
C | HEC606 |
C | HEC607 |
C | HOH729 |
E | THR490 |
E | TYR491 |
E | HOH704 |
E | HOH753 |
E | HOH948 |
site_id | CC1 |
Number of Residues | 21 |
Details | BINDING SITE FOR RESIDUE HEC E 602 |
Chain | Residue |
E | TYR140 |
E | LYS141 |
E | CYS196 |
E | HIS200 |
E | GLU203 |
E | HIS228 |
E | ASN259 |
E | CYS263 |
E | CYS266 |
E | HIS267 |
E | SER277 |
E | ARG278 |
E | ARG319 |
E | LEU320 |
E | MET339 |
E | HIS347 |
E | HEC603 |
E | HEC607 |
E | HOH799 |
E | HOH851 |
E | HOH886 |
site_id | CC2 |
Number of Residues | 17 |
Details | BINDING SITE FOR RESIDUE HEC E 603 |
Chain | Residue |
E | THR122 |
E | HIS123 |
E | LYS141 |
E | LYS144 |
E | LEU145 |
E | VAL167 |
E | CYS196 |
E | CYS199 |
E | HIS200 |
E | CYS263 |
E | HIS267 |
E | PHE272 |
E | ALA274 |
E | HEC602 |
E | HEC605 |
E | HOH765 |
E | HOH891 |
site_id | CC3 |
Number of Residues | 18 |
Details | BINDING SITE FOR RESIDUE HEC E 604 |
Chain | Residue |
A | SER389 |
A | GLU390 |
A | ARG391 |
E | TYR81 |
E | TYR88 |
E | PRO94 |
E | GLU96 |
E | ASP102 |
E | CYS103 |
E | CYS106 |
E | HIS107 |
E | GLU110 |
E | HIS173 |
E | HIS184 |
E | ILE188 |
E | HEC605 |
E | HOH792 |
E | HOH993 |
site_id | CC4 |
Number of Residues | 22 |
Details | BINDING SITE FOR RESIDUE HEC E 605 |
Chain | Residue |
A | HIS388 |
A | SER389 |
A | HOH709 |
E | TYR81 |
E | PRO84 |
E | HIS107 |
E | TRP114 |
E | HIS123 |
E | VAL167 |
E | GLY168 |
E | CYS169 |
E | CYS172 |
E | HIS173 |
E | MET190 |
E | PRO191 |
E | LYS262 |
E | ASP264 |
E | ARG269 |
E | HIS270 |
E | PHE272 |
E | HEC603 |
E | HEC604 |
site_id | CC5 |
Number of Residues | 21 |
Details | BINDING SITE FOR RESIDUE HEC E 606 |
Chain | Residue |
A | HEC608 |
E | CYS283 |
E | HIS287 |
E | ASN294 |
E | TYR298 |
E | PRO332 |
E | THR333 |
E | CYS334 |
E | CYS337 |
E | HIS338 |
E | THR353 |
E | ARG354 |
E | TRP355 |
E | ALA356 |
E | TRP380 |
E | MET400 |
E | ALA482 |
E | HIS483 |
E | HEC607 |
E | HEC608 |
E | HOH706 |
site_id | CC6 |
Number of Residues | 23 |
Details | BINDING SITE FOR RESIDUE HEC E 607 |
Chain | Residue |
A | HEC608 |
E | PRO226 |
E | SER227 |
E | HIS228 |
E | ASP231 |
E | ALA234 |
E | CYS256 |
E | HIS257 |
E | ASN259 |
E | ASN265 |
E | CYS266 |
E | ALA282 |
E | CYS283 |
E | CYS286 |
E | HIS287 |
E | CYS334 |
E | HIS338 |
E | ILE349 |
E | THR353 |
E | ALA356 |
E | HEC602 |
E | HEC606 |
E | HOH717 |
site_id | CC7 |
Number of Residues | 21 |
Details | BINDING SITE FOR RESIDUE HEC E 608 |
Chain | Residue |
C | TRP114 |
C | LYS262 |
C | ASP264 |
C | THR268 |
C | ARG269 |
C | HOH735 |
E | HIS303 |
E | LEU306 |
E | ASN330 |
E | PRO332 |
E | THR383 |
E | CYS384 |
E | CYS387 |
E | HIS388 |
E | PHE392 |
E | TYR396 |
E | VAL484 |
E | HEC606 |
E | HOH757 |
E | HOH776 |
E | HOH782 |
site_id | CC8 |
Number of Residues | 5 |
Details | BINDING SITE FOR RESIDUE PO4 E 609 |
Chain | Residue |
E | LEU39 |
E | ASP40 |
E | LYS43 |
E | GLU48 |
E | HOH989 |
Functional Information from SwissProt/UniProt
site_id | SWS_FT_FI1 |
Number of Residues | 48 |
Details | BINDING: covalent => ECO:0000269|PubMed:24302732, ECO:0000269|PubMed:9095195, ECO:0007744|PDB:1FGJ, ECO:0007744|PDB:4N4N, ECO:0007744|PDB:4N4O |
Chain | Residue | Details |
A | CYS253 | |
A | CYS256 | |
A | CYS263 | |
A | CYS266 | |
A | CYS283 | |
A | CYS286 | |
A | CYS334 | |
A | CYS337 | |
A | CYS384 | |
A | CYS387 | |
C | CYS103 | |
C | CYS106 | |
C | CYS169 | |
C | CYS172 | |
C | CYS196 | |
C | CYS199 | |
C | CYS253 | |
C | CYS256 | |
C | CYS263 | |
C | CYS266 | |
C | CYS283 | |
C | CYS286 | |
C | CYS334 | |
C | CYS337 | |
C | CYS384 | |
C | CYS387 | |
E | CYS103 | |
E | CYS106 | |
E | CYS169 | |
E | CYS172 | |
E | CYS196 | |
E | CYS199 | |
E | CYS253 | |
E | CYS256 | |
E | CYS263 | |
E | CYS266 | |
E | CYS283 | |
E | CYS286 | |
E | CYS334 | |
E | CYS337 | |
E | CYS384 | |
E | CYS387 | |
A | CYS103 | |
A | CYS106 | |
A | CYS169 | |
A | CYS172 | |
A | CYS196 | |
A | CYS199 |
site_id | SWS_FT_FI2 |
Number of Residues | 45 |
Details | BINDING: axial binding residue => ECO:0000269|PubMed:24302732, ECO:0000269|PubMed:9095195, ECO:0007744|PDB:1FGJ, ECO:0007744|PDB:4N4N, ECO:0007744|PDB:4N4O |
Chain | Residue | Details |
A | HIS257 | |
A | HIS267 | |
A | HIS270 | |
A | HIS287 | |
A | HIS303 | |
A | HIS338 | |
A | HIS347 | |
A | HIS388 | |
A | HIS483 | |
C | HIS107 | |
C | HIS123 | |
C | HIS173 | |
C | HIS184 | |
C | HIS200 | |
C | HIS228 | |
C | HIS257 | |
C | HIS267 | |
C | HIS270 | |
C | HIS287 | |
C | HIS303 | |
C | HIS338 | |
C | HIS347 | |
C | HIS388 | |
C | HIS483 | |
E | HIS107 | |
E | HIS123 | |
E | HIS173 | |
E | HIS184 | |
E | HIS200 | |
E | HIS228 | |
E | HIS257 | |
E | HIS267 | |
E | HIS270 | |
E | HIS287 | |
E | HIS303 | |
E | HIS338 | |
E | HIS347 | |
E | HIS388 | |
E | HIS483 | |
A | HIS107 | |
A | HIS123 | |
A | HIS173 | |
A | HIS184 | |
A | HIS200 | |
A | HIS228 |
site_id | SWS_FT_FI3 |
Number of Residues | 3 |
Details | BINDING: BINDING => ECO:0000269|PubMed:24302732, ECO:0007744|PDB:4N4O |
Chain | Residue | Details |
A | HIS292 | |
C | HIS292 | |
E | HIS292 |
site_id | SWS_FT_FI4 |
Number of Residues | 3 |
Details | BINDING: covalent; ligand shared between tetrameric partners => ECO:0000269|PubMed:24302732 |
Chain | Residue | Details |
A | TYR491 | |
C | TYR491 | |
E | TYR491 |
Catalytic Information from CSA
site_id | MCSA1 |
Number of Residues | 5 |
Details | M-CSA 581 |
Chain | Residue | Details |
A | HIS257 | electrostatic stabiliser |
A | ASP291 | steric role |
A | HIS292 | steric role |
A | TYR358 | steric role |
A | TYR491 | activator, covalently attached |
site_id | MCSA2 |
Number of Residues | 5 |
Details | M-CSA 581 |
Chain | Residue | Details |
C | HIS257 | electrostatic stabiliser |
C | ASP291 | steric role |
C | HIS292 | steric role |
C | TYR358 | steric role |
C | TYR491 | activator, covalently attached |
site_id | MCSA3 |
Number of Residues | 5 |
Details | M-CSA 581 |
Chain | Residue | Details |
E | HIS257 | electrostatic stabiliser |
E | ASP291 | steric role |
E | HIS292 | steric role |
E | TYR358 | steric role |
E | TYR491 | activator, covalently attached |