4N4M

Kuenenia stuttgartiensis hydroxylamine oxidoreductase soaked in phenyl hydrazine

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0006809	biological_process	nitric oxide biosynthetic process
A	0016491	molecular_function	oxidoreductase activity
A	0019331	biological_process	anaerobic respiration, using ammonium as electron donor
A	0020037	molecular_function	heme binding
A	0033740	molecular_function	hydroxylamine oxidoreductase activity
A	0042802	molecular_function	identical protein binding
A	0044222	cellular_component	anammoxosome
A	0046872	molecular_function	metal ion binding
A	0070207	biological_process	protein homotrimerization

Functional Information from PDB Data

site_id	AC1
Number of Residues	7
Details	BINDING SITE FOR RESIDUE PO4 A 601

Chain	Residue
A	ARG79
A	TRP516
A	ARG519
A	HOH732
A	HOH766
A	HOH768
A	HOH769

---

site_id	AC2
Number of Residues	7
Details	BINDING SITE FOR RESIDUE PO4 A 602

Chain	Residue
A	LYS83
A	LYS148
A	TRP516
A	HOH770
A	HOH782
A	ARG79
A	GLY80

---

site_id	AC3
Number of Residues	6
Details	BINDING SITE FOR RESIDUE PO4 A 603

Chain	Residue
A	LYS472
A	LYS472
A	LYS472
A	HOH842
A	HOH842
A	HOH842

---

site_id	AC4
Number of Residues	3
Details	BINDING SITE FOR RESIDUE PO4 A 604

Chain	Residue
A	LYS112
A	ASN113
A	HOH915

---

site_id	AC5
Number of Residues	4
Details	BINDING SITE FOR RESIDUE EDO A 605

Chain	Residue
A	GLY165
A	ASN166
A	ASN167
A	LYS170

---

site_id	AC6
Number of Residues	3
Details	BINDING SITE FOR RESIDUE EDO A 606

Chain	Residue
A	TYR176
A	ARG191
A	HOH765

---

site_id	AC7
Number of Residues	3
Details	BINDING SITE FOR RESIDUE EDO A 607

Chain	Residue
A	LYS289
A	LYS290
A	ASN295

---

site_id	AC8
Number of Residues	6
Details	BINDING SITE FOR RESIDUE EDO A 608

Chain	Residue
A	LEU291
A	TYR303
A	GLN307
A	ASN308
A	LEU345
A	ASP348

---

site_id	AC9
Number of Residues	6
Details	BINDING SITE FOR RESIDUE EDO A 609

Chain	Residue
A	ILE127
A	ASP130
A	ARG240
A	HIS241
A	CYS349
A	HEC614

---

site_id	BC1
Number of Residues	2
Details	BINDING SITE FOR RESIDUE EDO A 610

Chain	Residue
A	VAL381
A	LEU408

---

site_id	BC2
Number of Residues	3
Details	BINDING SITE FOR RESIDUE EDO A 611

Chain	Residue
A	PRO90
A	ASP357
A	LYS360

---

site_id	BC3
Number of Residues	2
Details	BINDING SITE FOR RESIDUE PHZ A 612

Chain	Residue
A	TYR451
A	HEC616

---

site_id	BC4
Number of Residues	23
Details	BINDING SITE FOR RESIDUE HEC A 613

Chain	Residue
A	GLN47
A	TRP94
A	TRP101
A	SER105
A	GLN106
A	THR107
A	PHE111
A	GLU115
A	CYS116
A	CYS119
A	HIS120
A	GLN123
A	CYS160
A	ALA161
A	GLY165
A	HIS168
A	LEU171
A	SER351
A	PRO352
A	ARG353
A	HEC614
A	HOH790
A	HOH791

---

site_id	BC5
Number of Residues	21
Details	BINDING SITE FOR RESIDUE HEC A 614

Chain	Residue
A	TRP94
A	HIS120
A	ILE127
A	HIS136
A	VAL158
A	GLY159
A	CYS160
A	CYS163
A	HIS164
A	MET173
A	ARG233
A	SER235
A	ARG240
A	HIS241
A	HIS350
A	SER351
A	EDO609
A	HEC613
A	HEC615
A	HOH741
A	HOH743

---

site_id	BC6
Number of Residues	21
Details	BINDING SITE FOR RESIDUE HEC A 615

Chain	Residue
A	ARG143
A	GLY144
A	ILE145
A	ILE147
A	CYS179
A	CYS182
A	HIS183
A	CYS234
A	PHE243
A	PRO245
A	HEC614
A	HEC617
A	HOH889
A	HOH891
A	HOH895
A	HOH897
A	HOH898
A	HOH902
A	SER135
A	HIS136
A	ARG142

---

site_id	BC7
Number of Residues	21
Details	BINDING SITE FOR RESIDUE HEC A 616

Chain	Residue
A	ASN205
A	PHE209
A	HIS212
A	GLY222
A	CYS223
A	CYS226
A	HIS227
A	VAL256
A	CYS257
A	HIS258
A	TYR320
A	ASP322
A	MET323
A	LYS439
A	THR450
A	TYR451
A	ARG525
A	PHZ612
A	HEC618
A	HOH709
A	HOH723

---

site_id	BC8
Number of Residues	21
Details	BINDING SITE FOR RESIDUE HEC A 617

Chain	Residue
A	ARG143
A	TYR176
A	CYS179
A	HIS183
A	GLU186
A	HIS190
A	CYS234
A	CYS237
A	HIS238
A	ALA248
A	ARG249
A	LYS290
A	LEU291
A	MET306
A	GLY309
A	HIS311
A	LYS518
A	HEC615
A	HOH757
A	HOH758
A	HOH901

---

site_id	BC9
Number of Residues	22
Details	BINDING SITE FOR RESIDUE HEC A 618

Chain	Residue
A	GLY196
A	SER197
A	HIS198
A	ALA201
A	ASN205
A	CYS226
A	HIS227
A	ILE229
A	ALA230
A	GLY236
A	ALA253
A	CYS254
A	CYS257
A	HIS258
A	CYS301
A	GLN314
A	TYR320
A	HEC616
A	HOH708
A	HOH710
A	HOH723
A	HOH724

---

site_id	CC1
Number of Residues	21
Details	BINDING SITE FOR RESIDUE HEC A 619

Chain	Residue
A	HIS258
A	GLU265
A	TYR269
A	PRO299
A	THR300
A	CYS301
A	CYS304
A	HIS305
A	GLY317
A	THR318
A	TRP342
A	TYR438
A	ALA442
A	HIS443
A	HEC620
A	HOH705
A	HOH706
A	HOH707
A	HOH709
A	HOH710
A	HOH946

---

site_id	CC2
Number of Residues	21
Details	BINDING SITE FOR RESIDUE HEC A 620

Chain	Residue
A	TYR95
A	ARG233
A	SER235
A	THR239
A	ARG240
A	ILE273
A	HIS274
A	LEU277
A	TYR296
A	ARG297
A	PRO299
A	TYR303
A	CYS346
A	CYS349
A	HIS350
A	PHE354
A	LYS358
A	MET444
A	HEC619
A	HOH821
A	HOH965

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	16
Details	BINDING: covalent => ECO:0000255|PIRSR:PIRSR000242-1, ECO:0000269|PubMed:24302732, ECO:0000269|PubMed:26249351, ECO:0007744|PDB:4N4J, ECO:0007744|PDB:4N4K, ECO:0007744|PDB:4N4L, ECO:0007744|PDB:4N4M, ECO:0007744|PDB:4RWM

Chain	Residue	Details
A	CYS116
A	CYS237
A	CYS254
A	CYS257
A	CYS301
A	CYS304
A	CYS346
A	CYS349
A	CYS119
A	CYS160
A	CYS163
A	CYS179
A	CYS182
A	CYS223
A	CYS226
A	CYS234

---

site_id	SWS_FT_FI2
Number of Residues	15
Details	BINDING: axial binding residue => ECO:0000255|PIRSR:PIRSR000242-2, ECO:0000269|PubMed:24302732, ECO:0000269|PubMed:26249351, ECO:0007744|PDB:4N4J, ECO:0007744|PDB:4N4K, ECO:0007744|PDB:4N4L, ECO:0007744|PDB:4N4M, ECO:0007744|PDB:4RWM

Chain	Residue	Details
A	HIS120
A	HIS258
A	HIS274
A	HIS305
A	HIS311
A	HIS350
A	HIS443
A	HIS136
A	HIS164
A	HIS168
A	HIS183
A	HIS198
A	HIS227
A	HIS238
A	HIS241

---

site_id	SWS_FT_FI3
Number of Residues	1
Details	BINDING: BINDING => ECO:0000269|PubMed:24302732, ECO:0007744|PDB:4N4K

Chain	Residue	Details
A	HIS263

---

site_id	SWS_FT_FI4
Number of Residues	1
Details	BINDING: covalent; ligand shared between tetrameric partners => ECO:0000269|PubMed:24302732, ECO:0000269|PubMed:26249351

Chain	Residue	Details
A	TYR451

---