4N24
Crystal structure of Protein Arginine Deiminase 2 (100 uM Ca2+)
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0000791 | cellular_component | euchromatin |
| A | 0004668 | molecular_function | protein-arginine deiminase activity |
| A | 0005509 | molecular_function | calcium ion binding |
| A | 0005576 | cellular_component | extracellular region |
| A | 0005634 | cellular_component | nucleus |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0005829 | cellular_component | cytosol |
| A | 0006338 | biological_process | chromatin remodeling |
| A | 0016787 | molecular_function | hydrolase activity |
| A | 0021762 | biological_process | substantia nigra development |
| A | 0030331 | molecular_function | nuclear estrogen receptor binding |
| A | 0030520 | biological_process | estrogen receptor signaling pathway |
| A | 0035578 | cellular_component | azurophil granule lumen |
| A | 0042803 | molecular_function | protein homodimerization activity |
| A | 0045815 | biological_process | transcription initiation-coupled chromatin remodeling |
| A | 0046872 | molecular_function | metal ion binding |
| A | 0070062 | cellular_component | extracellular exosome |
| A | 0070100 | biological_process | negative regulation of chemokine-mediated signaling pathway |
| A | 0140794 | molecular_function | histone arginine deiminase activity |
| A | 0140798 | molecular_function | histone H3R26 arginine deiminase activity |
| A | 1901624 | biological_process | negative regulation of lymphocyte chemotaxis |
| A | 1990830 | biological_process | cellular response to leukemia inhibitory factor |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE MRD A 701 |
| Chain | Residue |
| A | SER434 |
| A | GLU461 |
| A | LEU462 |
| A | TRP550 |
| A | HOH1027 |
| site_id | AC2 |
| Number of Residues | 1 |
| Details | BINDING SITE FOR RESIDUE MPD A 702 |
| Chain | Residue |
| A | HOH1076 |
| site_id | AC3 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE CA A 703 |
| Chain | Residue |
| A | VAL129 |
| A | GLU131 |
| A | HOH1251 |
| A | ASP123 |
| A | ASP125 |
| A | ASP127 |
| site_id | AC4 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE CA A 704 |
| Chain | Residue |
| A | GLU354 |
| A | PHE408 |
| A | LEU411 |
| A | HOH982 |
| A | HOH1090 |
| A | HOH1274 |
| site_id | AC5 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE GOL A 705 |
| Chain | Residue |
| A | THR300 |
| A | GLU354 |
| A | PHE355 |
| A | VAL651 |
| A | ARG653 |
| A | HOH1003 |
| A | HOH1090 |
| site_id | AC6 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE GOL A 706 |
| Chain | Residue |
| A | GLN350 |
| A | ASN590 |
| A | ASP634 |
| A | THR649 |
| site_id | AC7 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE ACT A 707 |
| Chain | Residue |
| A | GLY128 |
| A | GLN183 |
| site_id | AC8 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE MPD A 708 |
| Chain | Residue |
| A | SER371 |
| A | ARG395 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 1 |
| Details | ACT_SITE: Nucleophile => ECO:0000269|PubMed:25621824 |
| Chain | Residue | Details |
| A | CYS647 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 1 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:25621824, ECO:0007744|PDB:4N20, ECO:0007744|PDB:4N22, ECO:0007744|PDB:4N24, ECO:0007744|PDB:4N25, ECO:0007744|PDB:4N26, ECO:0007744|PDB:4N28, ECO:0007744|PDB:4N2A, ECO:0007744|PDB:4N2B, ECO:0007744|PDB:4N2C, ECO:0007744|PDB:4N2F, ECO:0007744|PDB:4N2G, ECO:0007744|PDB:4N2H, ECO:0007744|PDB:4N2I, ECO:0007744|PDB:4N2L, ECO:0007744|PDB:4N2M, ECO:0007744|PDB:4N2N |
| Chain | Residue | Details |
| A | ASP123 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 1 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:25621824, ECO:0007744|PDB:4N20, ECO:0007744|PDB:4N22, ECO:0007744|PDB:4N24, ECO:0007744|PDB:4N26, ECO:0007744|PDB:4N28, ECO:0007744|PDB:4N2A, ECO:0007744|PDB:4N2B, ECO:0007744|PDB:4N2C, ECO:0007744|PDB:4N2D, ECO:0007744|PDB:4N2E, ECO:0007744|PDB:4N2F, ECO:0007744|PDB:4N2G, ECO:0007744|PDB:4N2H, ECO:0007744|PDB:4N2I, ECO:0007744|PDB:4N2K, ECO:0007744|PDB:4N2L, ECO:0007744|PDB:4N2M, ECO:0007744|PDB:4N2N |
| Chain | Residue | Details |
| A | ASP125 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 3 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:25621824, ECO:0007744|PDB:4N20, ECO:0007744|PDB:4N22, ECO:0007744|PDB:4N24, ECO:0007744|PDB:4N25, ECO:0007744|PDB:4N26, ECO:0007744|PDB:4N28, ECO:0007744|PDB:4N2A, ECO:0007744|PDB:4N2B, ECO:0007744|PDB:4N2C, ECO:0007744|PDB:4N2D, ECO:0007744|PDB:4N2E, ECO:0007744|PDB:4N2F, ECO:0007744|PDB:4N2G, ECO:0007744|PDB:4N2H, ECO:0007744|PDB:4N2I, ECO:0007744|PDB:4N2K, ECO:0007744|PDB:4N2L, ECO:0007744|PDB:4N2M, ECO:0007744|PDB:4N2N |
| Chain | Residue | Details |
| A | ASP127 | |
| A | VAL129 | |
| A | GLU131 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 2 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:25621824, ECO:0007744|PDB:4N25, ECO:0007744|PDB:4N26, ECO:0007744|PDB:4N28, ECO:0007744|PDB:4N2A, ECO:0007744|PDB:4N2B, ECO:0007744|PDB:4N2E, ECO:0007744|PDB:4N2G, ECO:0007744|PDB:4N2I, ECO:0007744|PDB:4N2L, ECO:0007744|PDB:4N2N |
| Chain | Residue | Details |
| A | ASN154 | |
| A | ASP389 |
| site_id | SWS_FT_FI6 |
| Number of Residues | 2 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:25621824, ECO:0007744|PDB:4N25, ECO:0007744|PDB:4N26, ECO:0007744|PDB:4N28, ECO:0007744|PDB:4N2A, ECO:0007744|PDB:4N2B, ECO:0007744|PDB:4N2C, ECO:0007744|PDB:4N2E, ECO:0007744|PDB:4N2G, ECO:0007744|PDB:4N2I, ECO:0007744|PDB:4N2L, ECO:0007744|PDB:4N2N |
| Chain | Residue | Details |
| A | ASP156 | |
| A | ASP180 |
| site_id | SWS_FT_FI7 |
| Number of Residues | 1 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:25621824, ECO:0007744|PDB:4N26, ECO:0007744|PDB:4N28, ECO:0007744|PDB:4N2A, ECO:0007744|PDB:4N2B, ECO:0007744|PDB:4N2C, ECO:0007744|PDB:4N2E, ECO:0007744|PDB:4N2G, ECO:0007744|PDB:4N2I, ECO:0007744|PDB:4N2L, ECO:0007744|PDB:4N2N |
| Chain | Residue | Details |
| A | GLU158 |
| site_id | SWS_FT_FI8 |
| Number of Residues | 3 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:25621824, ECO:0007744|PDB:4N25, ECO:0007744|PDB:4N26, ECO:0007744|PDB:4N2A, ECO:0007744|PDB:4N2B, ECO:0007744|PDB:4N2C, ECO:0007744|PDB:4N2E, ECO:0007744|PDB:4N2I, ECO:0007744|PDB:4N2L |
| Chain | Residue | Details |
| A | ASP166 | |
| A | ASP169 | |
| A | LYS171 |
| site_id | SWS_FT_FI9 |
| Number of Residues | 1 |
| Details | BINDING: BINDING => ECO:0007744|PDB:4N25, ECO:0007744|PDB:4N26, ECO:0007744|PDB:4N28, ECO:0007744|PDB:4N2A, ECO:0007744|PDB:4N2B, ECO:0007744|PDB:4N2E, ECO:0007744|PDB:4N2G, ECO:0007744|PDB:4N2L, ECO:0007744|PDB:4N2N |
| Chain | Residue | Details |
| A | ASP177 |
| site_id | SWS_FT_FI10 |
| Number of Residues | 1 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:25621824, ECO:0007744|PDB:4N28, ECO:0007744|PDB:4N2B, ECO:0007744|PDB:4N2C, ECO:0007744|PDB:4N2I |
| Chain | Residue | Details |
| A | GLU354 |
| site_id | SWS_FT_FI11 |
| Number of Residues | 3 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:25621824, ECO:0007744|PDB:4N28, ECO:0007744|PDB:4N2B, ECO:0007744|PDB:4N2C, ECO:0007744|PDB:4N2E, ECO:0007744|PDB:4N2I |
| Chain | Residue | Details |
| A | PHE408 | |
| A | LEU411 | |
| A | GLU412 |
