4N1E

Structural evidence for antigen receptor evolution

Functional Information from GO Data

Chain	GOid	namespace	contents
I	0003796	molecular_function	lysozyme activity
I	0005515	molecular_function	protein binding
I	0005576	cellular_component	extracellular region
I	0005615	cellular_component	extracellular space
I	0005737	cellular_component	cytoplasm
I	0005783	cellular_component	endoplasmic reticulum
I	0016231	molecular_function	beta-N-acetylglucosaminidase activity
I	0016798	molecular_function	hydrolase activity, acting on glycosyl bonds
I	0016998	biological_process	cell wall macromolecule catabolic process
I	0031640	biological_process	killing of cells of another organism
I	0042742	biological_process	defense response to bacterium
I	0042802	molecular_function	identical protein binding
I	0050829	biological_process	defense response to Gram-negative bacterium
I	0050830	biological_process	defense response to Gram-positive bacterium
I	0051672	biological_process	obsolete catabolism by organism of cell wall peptidoglycan in other organism
J	0003796	molecular_function	lysozyme activity
J	0005515	molecular_function	protein binding
J	0005576	cellular_component	extracellular region
J	0005615	cellular_component	extracellular space
J	0005737	cellular_component	cytoplasm
J	0005783	cellular_component	endoplasmic reticulum
J	0016231	molecular_function	beta-N-acetylglucosaminidase activity
J	0016798	molecular_function	hydrolase activity, acting on glycosyl bonds
J	0016998	biological_process	cell wall macromolecule catabolic process
J	0031640	biological_process	killing of cells of another organism
J	0042742	biological_process	defense response to bacterium
J	0042802	molecular_function	identical protein binding
J	0050829	biological_process	defense response to Gram-negative bacterium
J	0050830	biological_process	defense response to Gram-positive bacterium
J	0051672	biological_process	obsolete catabolism by organism of cell wall peptidoglycan in other organism
K	0003796	molecular_function	lysozyme activity
K	0005515	molecular_function	protein binding
K	0005576	cellular_component	extracellular region
K	0005615	cellular_component	extracellular space
K	0005737	cellular_component	cytoplasm
K	0005783	cellular_component	endoplasmic reticulum
K	0016231	molecular_function	beta-N-acetylglucosaminidase activity
K	0016798	molecular_function	hydrolase activity, acting on glycosyl bonds
K	0016998	biological_process	cell wall macromolecule catabolic process
K	0031640	biological_process	killing of cells of another organism
K	0042742	biological_process	defense response to bacterium
K	0042802	molecular_function	identical protein binding
K	0050829	biological_process	defense response to Gram-negative bacterium
K	0050830	biological_process	defense response to Gram-positive bacterium
K	0051672	biological_process	obsolete catabolism by organism of cell wall peptidoglycan in other organism
L	0003796	molecular_function	lysozyme activity
L	0005515	molecular_function	protein binding
L	0005576	cellular_component	extracellular region
L	0005615	cellular_component	extracellular space
L	0005737	cellular_component	cytoplasm
L	0005783	cellular_component	endoplasmic reticulum
L	0016231	molecular_function	beta-N-acetylglucosaminidase activity
L	0016798	molecular_function	hydrolase activity, acting on glycosyl bonds
L	0016998	biological_process	cell wall macromolecule catabolic process
L	0031640	biological_process	killing of cells of another organism
L	0042742	biological_process	defense response to bacterium
L	0042802	molecular_function	identical protein binding
L	0050829	biological_process	defense response to Gram-negative bacterium
L	0050830	biological_process	defense response to Gram-positive bacterium
L	0051672	biological_process	obsolete catabolism by organism of cell wall peptidoglycan in other organism

Functional Information from PROSITE/UniProt

site_id	PS00128
Number of Residues	19
Details	GLYCOSYL_HYDROL_F22_1 Glycosyl hydrolases family 22 (GH22) domain signature. CnipCsaLlssDItasvnC

Chain	Residue	Details
I	CYS76-CYS94

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	8
Details	ACT_SITE:

Chain	Residue	Details
I	GLU35
I	ASP52
J	GLU35
J	ASP52
K	GLU35
K	ASP52
L	GLU35
L	ASP52

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site_id	SWS_FT_FI2
Number of Residues	4
Details	BINDING:

Chain	Residue	Details
I	ASP101
J	ASP101
K	ASP101
L	ASP101

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Catalytic Information from CSA

site_id	MCSA1
Number of Residues	6
Details	M-CSA 203

Chain	Residue	Details
I	GLU35	hydrogen bond acceptor, hydrogen bond donor, proton acceptor, proton donor
I	ASN46
I	ASP48
I	SER50
I	ASP52	covalently attached, electrostatic stabiliser, nucleofuge, nucleophile, polar/non-polar interaction
I	ASN59

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site_id	MCSA2
Number of Residues	6
Details	M-CSA 203

Chain	Residue	Details
J	GLU35	hydrogen bond acceptor, hydrogen bond donor, proton acceptor, proton donor
J	ASN46
J	ASP48
J	SER50
J	ASP52	covalently attached, electrostatic stabiliser, nucleofuge, nucleophile, polar/non-polar interaction
J	ASN59

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site_id	MCSA3
Number of Residues	6
Details	M-CSA 203

Chain	Residue	Details
K	GLU35	hydrogen bond acceptor, hydrogen bond donor, proton acceptor, proton donor
K	ASN46
K	ASP48
K	SER50
K	ASP52	covalently attached, electrostatic stabiliser, nucleofuge, nucleophile, polar/non-polar interaction
K	ASN59

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site_id	MCSA4
Number of Residues	6
Details	M-CSA 203

Chain	Residue	Details
L	GLU35	hydrogen bond acceptor, hydrogen bond donor, proton acceptor, proton donor
L	ASN46
L	ASP48
L	SER50
L	ASP52	covalently attached, electrostatic stabiliser, nucleofuge, nucleophile, polar/non-polar interaction
L	ASN59

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