4N1B
STRUCTURE OF KEAP1 KELCH DOMAIN WITH(1S,2R)-2-[(1S)-1-[(1-oxo-2,3-dihydro-1H-isoindol-2-Yl)methyl]-1,2,3,4-tetrahydroisoquinoline-2-Carbonyl]cyclohexane-1-carboxylic acid
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0008134 | molecular_function | transcription factor binding |
| A | 0016567 | biological_process | protein ubiquitination |
| A | 0031463 | cellular_component | Cul3-RING ubiquitin ligase complex |
| B | 0008134 | molecular_function | transcription factor binding |
| B | 0016567 | biological_process | protein ubiquitination |
| B | 0031463 | cellular_component | Cul3-RING ubiquitin ligase complex |
| C | 0008134 | molecular_function | transcription factor binding |
| C | 0016567 | biological_process | protein ubiquitination |
| C | 0031463 | cellular_component | Cul3-RING ubiquitin ligase complex |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 9 |
| Details | BINDING SITE FOR RESIDUE 2FS A 701 |
| Chain | Residue |
| A | TYR334 |
| A | SER363 |
| A | ASN382 |
| A | ASN414 |
| A | ARG415 |
| A | GLY509 |
| A | ALA556 |
| A | TYR572 |
| A | SER602 |
| site_id | AC2 |
| Number of Residues | 8 |
| Details | BINDING SITE FOR RESIDUE 2FS B 701 |
| Chain | Residue |
| B | GLY364 |
| B | ASN414 |
| B | ARG415 |
| B | GLY509 |
| B | ALA556 |
| B | TYR572 |
| B | SER602 |
| B | ACT702 |
| site_id | AC3 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE ACT B 702 |
| Chain | Residue |
| B | TYR525 |
| B | GLN530 |
| B | SER555 |
| B | 2FS701 |
| site_id | AC4 |
| Number of Residues | 9 |
| Details | BINDING SITE FOR RESIDUE 2FS C 701 |
| Chain | Residue |
| C | TYR334 |
| C | GLY364 |
| C | ASN414 |
| C | ARG415 |
| C | GLY509 |
| C | ALA556 |
| C | TYR572 |
| C | SER602 |
| C | ACT702 |
| site_id | AC5 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE ACT C 702 |
| Chain | Residue |
| C | TYR525 |
| C | GLN530 |
| C | SER555 |
| C | 2FS701 |
Functional Information from SwissProt/UniProt
| Chain | Residue | Details |
| A | CYS434 | |
| B | CYS434 | |
| C | CYS434 | |
| Chain | Residue | Details |
| A | CYS434 | |
| B | CYS434 | |
| C | CYS434 | |
