4N0J
Crystal structure of dimethyllysine hen egg-white lysozyme in complex with sclx4 at 1.9 A resolution
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0003796 | molecular_function | lysozyme activity |
| A | 0005515 | molecular_function | protein binding |
| A | 0005576 | cellular_component | extracellular region |
| A | 0005615 | cellular_component | extracellular space |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0005783 | cellular_component | endoplasmic reticulum |
| A | 0016231 | molecular_function | beta-N-acetylglucosaminidase activity |
| A | 0016798 | molecular_function | hydrolase activity, acting on glycosyl bonds |
| A | 0016998 | biological_process | cell wall macromolecule catabolic process |
| A | 0031640 | biological_process | killing of cells of another organism |
| A | 0042742 | biological_process | defense response to bacterium |
| A | 0042802 | molecular_function | identical protein binding |
| A | 0050829 | biological_process | defense response to Gram-negative bacterium |
| A | 0050830 | biological_process | defense response to Gram-positive bacterium |
| A | 0051672 | biological_process | obsolete catabolism by organism of cell wall peptidoglycan in other organism |
| B | 0003796 | molecular_function | lysozyme activity |
| B | 0005515 | molecular_function | protein binding |
| B | 0005576 | cellular_component | extracellular region |
| B | 0005615 | cellular_component | extracellular space |
| B | 0005737 | cellular_component | cytoplasm |
| B | 0005783 | cellular_component | endoplasmic reticulum |
| B | 0016231 | molecular_function | beta-N-acetylglucosaminidase activity |
| B | 0016798 | molecular_function | hydrolase activity, acting on glycosyl bonds |
| B | 0016998 | biological_process | cell wall macromolecule catabolic process |
| B | 0031640 | biological_process | killing of cells of another organism |
| B | 0042742 | biological_process | defense response to bacterium |
| B | 0042802 | molecular_function | identical protein binding |
| B | 0050829 | biological_process | defense response to Gram-negative bacterium |
| B | 0050830 | biological_process | defense response to Gram-positive bacterium |
| B | 0051672 | biological_process | obsolete catabolism by organism of cell wall peptidoglycan in other organism |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 20 |
| Details | BINDING SITE FOR RESIDUE T3Y A 201 |
| Chain | Residue |
| A | TYR23 |
| B | ARG5 |
| B | MLY33 |
| B | PHE38 |
| B | PRO70 |
| B | GLY71 |
| B | TRP123 |
| B | HOH336 |
| B | HOH338 |
| B | HOH383 |
| B | HOH390 |
| A | ASN106 |
| B | HOH392 |
| A | TRP111 |
| A | ARG112 |
| A | MLY116 |
| A | GLY117 |
| A | GOL204 |
| A | HOH326 |
| A | HOH370 |
| site_id | AC2 |
| Number of Residues | 15 |
| Details | BINDING SITE FOR RESIDUE T3Y A 202 |
| Chain | Residue |
| A | DM01 |
| A | PHE3 |
| A | GLU7 |
| A | ALA10 |
| A | ALA11 |
| A | ARG14 |
| A | HIS15 |
| A | HOH330 |
| A | HOH331 |
| A | HOH332 |
| A | HOH353 |
| A | HOH354 |
| A | HOH355 |
| A | HOH364 |
| A | HOH365 |
| site_id | AC3 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE CL A 203 |
| Chain | Residue |
| A | SER24 |
| A | GLY26 |
| A | GLN121 |
| site_id | AC4 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE GOL A 204 |
| Chain | Residue |
| A | ASN27 |
| A | GLY117 |
| A | THR118 |
| A | T3Y201 |
| A | HOH306 |
| B | ARG114 |
| site_id | AC5 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE GOL A 205 |
| Chain | Residue |
| A | DM01 |
| A | GLY16 |
| A | ASP18 |
| A | ASN19 |
| A | TYR20 |
| A | GLN41 |
| site_id | AC6 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE GOL A 206 |
| Chain | Residue |
| A | PHE34 |
| A | ARG114 |
| A | THR118 |
| A | ASP119 |
| A | ALA122 |
| A | TRP123 |
| B | T3Y201 |
| site_id | AC7 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE NA A 207 |
| Chain | Residue |
| A | SER60 |
| A | CYS64 |
| A | SER72 |
| A | ARG73 |
| A | HOH308 |
| A | HOH338 |
| site_id | AC8 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE MG A 208 |
| Chain | Residue |
| A | GLU35 |
| A | HOH317 |
| A | HOH321 |
| A | HOH325 |
| A | HOH385 |
| A | HOH387 |
| site_id | AC9 |
| Number of Residues | 22 |
| Details | BINDING SITE FOR RESIDUE T3Y B 201 |
| Chain | Residue |
| A | ARG5 |
| A | MLY33 |
| A | GLY71 |
| A | SER72 |
| A | ARG73 |
| A | ALA122 |
| A | TRP123 |
| A | GOL206 |
| A | HOH314 |
| A | HOH318 |
| A | HOH384 |
| B | ASN106 |
| B | TRP111 |
| B | ARG112 |
| B | MLY116 |
| B | GLY117 |
| B | GOL205 |
| B | HOH301 |
| B | HOH306 |
| B | HOH315 |
| B | HOH323 |
| B | HOH350 |
| site_id | BC1 |
| Number of Residues | 12 |
| Details | BINDING SITE FOR RESIDUE T3Y B 202 |
| Chain | Residue |
| B | HOH343 |
| B | HOH344 |
| B | HOH378 |
| B | HOH396 |
| B | DM01 |
| B | PHE3 |
| B | GLU7 |
| B | ALA10 |
| B | ALA11 |
| B | ARG14 |
| B | HIS15 |
| B | HOH333 |
| site_id | BC2 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE CL B 203 |
| Chain | Residue |
| B | GLY4 |
| B | ARG5 |
| B | CYS6 |
| B | GLU7 |
| site_id | BC3 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE CL B 204 |
| Chain | Residue |
| B | SER24 |
| B | GLY26 |
| B | GLN121 |
| B | GOL206 |
| B | HOH352 |
| site_id | BC4 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE GOL B 205 |
| Chain | Residue |
| A | PHE34 |
| A | ARG114 |
| B | ASN27 |
| B | MLY116 |
| B | GLY117 |
| B | T3Y201 |
| B | HOH388 |
| site_id | BC5 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE GOL B 206 |
| Chain | Residue |
| B | MLY13 |
| B | ASP18 |
| B | SER24 |
| B | GLN121 |
| B | ILE124 |
| B | CL204 |
| site_id | BC6 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE MG B 207 |
| Chain | Residue |
| B | GLU35 |
| B | HOH357 |
| B | HOH358 |
| B | HOH391 |
| B | HOH394 |
| B | HOH395 |
Functional Information from PROSITE/UniProt
| site_id | PS00128 |
| Number of Residues | 19 |
| Details | GLYCOSYL_HYDROL_F22_1 Glycosyl hydrolases family 22 (GH22) domain signature. CnipCsaLlssDItasvnC |
| Chain | Residue | Details |
| A | CYS76-CYS94 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 4 |
| Details | ACT_SITE: |
| Chain | Residue | Details |
| A | GLU35 | |
| A | ASP52 | |
| B | GLU35 | |
| B | ASP52 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 2 |
| Details | BINDING: |
| Chain | Residue | Details |
| A | ASP101 | |
| B | ASP101 |
Catalytic Information from CSA
| site_id | MCSA1 |
| Number of Residues | 6 |
| Details | M-CSA 203 |
| Chain | Residue | Details |
| A | GLU35 | hydrogen bond acceptor, hydrogen bond donor, proton acceptor, proton donor |
| A | ASN46 | |
| A | ASP48 | |
| A | SER50 | |
| A | ASP52 | covalently attached, electrostatic stabiliser, nucleofuge, nucleophile, polar/non-polar interaction |
| A | ASN59 |
| site_id | MCSA2 |
| Number of Residues | 6 |
| Details | M-CSA 203 |
| Chain | Residue | Details |
| B | GLU35 | hydrogen bond acceptor, hydrogen bond donor, proton acceptor, proton donor |
| B | ASN46 | |
| B | ASP48 | |
| B | SER50 | |
| B | ASP52 | covalently attached, electrostatic stabiliser, nucleofuge, nucleophile, polar/non-polar interaction |
| B | ASN59 |
