Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0006508 | biological_process | proteolysis |
| A | 0008234 | molecular_function | cysteine-type peptidase activity |
| B | 0006508 | biological_process | proteolysis |
| B | 0008234 | molecular_function | cysteine-type peptidase activity |
| C | 0006508 | biological_process | proteolysis |
| C | 0008234 | molecular_function | cysteine-type peptidase activity |
| D | 0006508 | biological_process | proteolysis |
| D | 0008234 | molecular_function | cysteine-type peptidase activity |
| E | 0006508 | biological_process | proteolysis |
| E | 0008234 | molecular_function | cysteine-type peptidase activity |
| F | 0006508 | biological_process | proteolysis |
| F | 0008234 | molecular_function | cysteine-type peptidase activity |
| G | 0006508 | biological_process | proteolysis |
| G | 0008234 | molecular_function | cysteine-type peptidase activity |
| H | 0006508 | biological_process | proteolysis |
| H | 0008234 | molecular_function | cysteine-type peptidase activity |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 13 |
| Details | BINDING SITE FOR RESIDUE 2EW A 401 |
| Chain | Residue |
| A | GLN141 |
| A | VAL285 |
| A | ASN286 |
| A | HIS287 |
| A | HOH535 |
| A | GLY145 |
| A | CYS147 |
| A | TRP148 |
| A | LYS187 |
| A | GLY191 |
| A | GLY192 |
| A | TYR193 |
| A | GLY260 |
| site_id | AC2 |
| Number of Residues | 12 |
| Details | BINDING SITE FOR RESIDUE 2EW B 401 |
| Chain | Residue |
| B | GLN141 |
| B | GLY145 |
| B | CYS147 |
| B | TRP148 |
| B | GLY191 |
| B | GLY192 |
| B | TYR193 |
| B | GLY260 |
| B | VAL285 |
| B | ASN286 |
| B | HIS287 |
| B | TYR334 |
| site_id | AC3 |
| Number of Residues | 18 |
| Details | BINDING SITE FOR RESIDUE 2EW C 401 |
| Chain | Residue |
| A | ASN312 |
| A | GLN316 |
| B | HOH554 |
| C | GLN141 |
| C | GLY145 |
| C | CYS147 |
| C | TRP148 |
| C | LYS187 |
| C | GLY191 |
| C | GLY192 |
| C | TYR193 |
| C | GLY260 |
| C | VAL285 |
| C | ASN286 |
| C | HIS287 |
| C | GLY288 |
| C | TYR334 |
| C | HOH555 |
| site_id | AC4 |
| Number of Residues | 15 |
| Details | BINDING SITE FOR RESIDUE 2EW D 401 |
| Chain | Residue |
| D | GLN141 |
| D | GLY145 |
| D | CYS147 |
| D | TRP148 |
| D | LYS187 |
| D | GLY191 |
| D | GLY192 |
| D | TYR193 |
| D | GLY260 |
| D | VAL285 |
| D | ASN286 |
| D | HIS287 |
| D | GLY288 |
| D | TYR334 |
| D | HOH578 |
| site_id | AC5 |
| Number of Residues | 14 |
| Details | BINDING SITE FOR RESIDUE 2EW E 401 |
| Chain | Residue |
| E | GLN141 |
| E | GLY145 |
| E | ALA146 |
| E | CYS147 |
| E | TRP148 |
| E | GLY191 |
| E | GLY192 |
| E | TYR193 |
| E | MET194 |
| E | GLY260 |
| E | VAL285 |
| E | ASN286 |
| E | HIS287 |
| E | TYR334 |
| site_id | AC6 |
| Number of Residues | 14 |
| Details | BINDING SITE FOR RESIDUE 2EW F 401 |
| Chain | Residue |
| F | GLN141 |
| F | GLY145 |
| F | ALA146 |
| F | CYS147 |
| F | TRP148 |
| F | LYS187 |
| F | GLY191 |
| F | GLY192 |
| F | TYR193 |
| F | GLY260 |
| F | VAL285 |
| F | ASN286 |
| F | HIS287 |
| F | TYR334 |
| site_id | AC7 |
| Number of Residues | 16 |
| Details | BINDING SITE FOR RESIDUE 2EW G 401 |
| Chain | Residue |
| G | HIS287 |
| G | TYR334 |
| G | HOH556 |
| F | ASN312 |
| F | GLN316 |
| G | GLN141 |
| G | GLY145 |
| G | CYS147 |
| G | TRP148 |
| G | GLY191 |
| G | GLY192 |
| G | TYR193 |
| G | MET194 |
| G | GLY260 |
| G | VAL285 |
| G | ASN286 |
| site_id | AC8 |
| Number of Residues | 18 |
| Details | BINDING SITE FOR RESIDUE 2EW H 401 |
| Chain | Residue |
| E | ASN312 |
| E | GLN316 |
| E | HOH532 |
| H | GLN141 |
| H | GLY145 |
| H | CYS147 |
| H | TRP148 |
| H | LYS187 |
| H | GLY191 |
| H | GLY192 |
| H | TYR193 |
| H | MET194 |
| H | GLY260 |
| H | VAL285 |
| H | ASN286 |
| H | HIS287 |
| H | TYR334 |
| H | HOH571 |
Functional Information from PROSITE/UniProt
| site_id | PS00139 |
| Number of Residues | 12 |
| Details | THIOL_PROTEASE_CYS Eukaryotic thiol (cysteine) proteases cysteine active site. QGsCGACWAfSA |
| Chain | Residue | Details |
| A | GLN141-ALA152 | |
| site_id | PS00639 |
| Number of Residues | 11 |
| Details | THIOL_PROTEASE_HIS Eukaryotic thiol (cysteine) proteases histidine active site. VNHGVLVVGYG |
| Chain | Residue | Details |
| A | VAL285-GLY295 | |
| site_id | PS00640 |
| Number of Residues | 20 |
| Details | THIOL_PROTEASE_ASN Eukaryotic thiol (cysteine) proteases asparagine active site. YWLvKNSWglnFGdqGYIrM |
| Chain | Residue | Details |
| A | TYR302-MET321 | |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 24 |
| Details | ACT_SITE: ACT_SITE => ECO:0000250 |
| Chain | Residue | Details |
| A | CYS147 | |
| D | CYS147 | |
| D | HIS287 | |
| D | ASN307 | |
| E | CYS147 | |
| E | HIS287 | |
| E | ASN307 | |
| F | CYS147 | |
| F | HIS287 | |
| F | ASN307 | |
| G | CYS147 | |
| A | HIS287 | |
| G | HIS287 | |
| G | ASN307 | |
| H | CYS147 | |
| H | HIS287 | |
| H | ASN307 | |
| A | ASN307 | |
| B | CYS147 | |
| B | HIS287 | |
| B | ASN307 | |
| C | CYS147 | |
| C | HIS287 | |
| C | ASN307 | |
| site_id | SWS_FT_FI2 |
| Number of Residues | 8 |
| Details | CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255 |
| Chain | Residue | Details |
| A | ASN120 | |
| B | ASN120 | |
| C | ASN120 | |
| D | ASN120 | |
| E | ASN120 | |
| F | ASN120 | |
| G | ASN120 | |
| H | ASN120 | |
