4MZO

Mouse cathepsin s with covalent ligand (3S,4S)-N-[(2E)-2-IMINOETHYL]-4-(MORPHOLIN-4-YLCARBONYL)-1-(PHENYLSULFONYL)PYRROLIDINE-3-CARBOXAMIDE

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0006508	biological_process	proteolysis
A	0008234	molecular_function	cysteine-type peptidase activity
B	0006508	biological_process	proteolysis
B	0008234	molecular_function	cysteine-type peptidase activity
C	0006508	biological_process	proteolysis
C	0008234	molecular_function	cysteine-type peptidase activity
D	0006508	biological_process	proteolysis
D	0008234	molecular_function	cysteine-type peptidase activity
E	0006508	biological_process	proteolysis
E	0008234	molecular_function	cysteine-type peptidase activity
F	0006508	biological_process	proteolysis
F	0008234	molecular_function	cysteine-type peptidase activity
G	0006508	biological_process	proteolysis
G	0008234	molecular_function	cysteine-type peptidase activity
H	0006508	biological_process	proteolysis
H	0008234	molecular_function	cysteine-type peptidase activity

Functional Information from PDB Data

site_id	AC1
Number of Residues	13
Details	BINDING SITE FOR RESIDUE 2EW A 401

Chain	Residue
A	GLN141
A	VAL285
A	ASN286
A	HIS287
A	HOH535
A	GLY145
A	CYS147
A	TRP148
A	LYS187
A	GLY191
A	GLY192
A	TYR193
A	GLY260

---

site_id	AC2
Number of Residues	12
Details	BINDING SITE FOR RESIDUE 2EW B 401

Chain	Residue
B	GLN141
B	GLY145
B	CYS147
B	TRP148
B	GLY191
B	GLY192
B	TYR193
B	GLY260
B	VAL285
B	ASN286
B	HIS287
B	TYR334

---

site_id	AC3
Number of Residues	18
Details	BINDING SITE FOR RESIDUE 2EW C 401

Chain	Residue
A	ASN312
A	GLN316
B	HOH554
C	GLN141
C	GLY145
C	CYS147
C	TRP148
C	LYS187
C	GLY191
C	GLY192
C	TYR193
C	GLY260
C	VAL285
C	ASN286
C	HIS287
C	GLY288
C	TYR334
C	HOH555

---

site_id	AC4
Number of Residues	15
Details	BINDING SITE FOR RESIDUE 2EW D 401

Chain	Residue
D	GLN141
D	GLY145
D	CYS147
D	TRP148
D	LYS187
D	GLY191
D	GLY192
D	TYR193
D	GLY260
D	VAL285
D	ASN286
D	HIS287
D	GLY288
D	TYR334
D	HOH578

---

site_id	AC5
Number of Residues	14
Details	BINDING SITE FOR RESIDUE 2EW E 401

Chain	Residue
E	GLN141
E	GLY145
E	ALA146
E	CYS147
E	TRP148
E	GLY191
E	GLY192
E	TYR193
E	MET194
E	GLY260
E	VAL285
E	ASN286
E	HIS287
E	TYR334

---

site_id	AC6
Number of Residues	14
Details	BINDING SITE FOR RESIDUE 2EW F 401

Chain	Residue
F	GLN141
F	GLY145
F	ALA146
F	CYS147
F	TRP148
F	LYS187
F	GLY191
F	GLY192
F	TYR193
F	GLY260
F	VAL285
F	ASN286
F	HIS287
F	TYR334

---

site_id	AC7
Number of Residues	16
Details	BINDING SITE FOR RESIDUE 2EW G 401

Chain	Residue
G	HIS287
G	TYR334
G	HOH556
F	ASN312
F	GLN316
G	GLN141
G	GLY145
G	CYS147
G	TRP148
G	GLY191
G	GLY192
G	TYR193
G	MET194
G	GLY260
G	VAL285
G	ASN286

---

site_id	AC8
Number of Residues	18
Details	BINDING SITE FOR RESIDUE 2EW H 401

Chain	Residue
E	ASN312
E	GLN316
E	HOH532
H	GLN141
H	GLY145
H	CYS147
H	TRP148
H	LYS187
H	GLY191
H	GLY192
H	TYR193
H	MET194
H	GLY260
H	VAL285
H	ASN286
H	HIS287
H	TYR334
H	HOH571

---

Functional Information from PROSITE/UniProt

site_id	PS00139
Number of Residues	12
Details	THIOL_PROTEASE_CYS Eukaryotic thiol (cysteine) proteases cysteine active site. QGsCGACWAfSA

Chain	Residue	Details
A	GLN141-ALA152

---

site_id	PS00639
Number of Residues	11
Details	THIOL_PROTEASE_HIS Eukaryotic thiol (cysteine) proteases histidine active site. VNHGVLVVGYG

Chain	Residue	Details
A	VAL285-GLY295

---

site_id	PS00640
Number of Residues	20
Details	THIOL_PROTEASE_ASN Eukaryotic thiol (cysteine) proteases asparagine active site. YWLvKNSWglnFGdqGYIrM

Chain	Residue	Details
A	TYR302-MET321

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	8
Details	Active site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU10088","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	8
Details	Active site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU10089","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	8
Details	Active site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU10090","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

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