4MZH
Crystal structure of human Spindlin1 bound to histone H3(K4me3-R8me2s) peptide
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0007276 | biological_process | gamete generation |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE MG A 301 |
| Chain | Residue |
| A | HOH439 |
| A | HOH439 |
| A | HOH459 |
| A | HOH459 |
| A | HOH460 |
| A | HOH460 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 63 |
| Details | Region: {"description":"Tudor-like domain 1","evidences":[{"source":"PubMed","id":"23077255","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"24589551","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 8 |
| Details | Region: {"description":"Histone H3K4me3 and H3R8me2a binding","evidences":[{"source":"PubMed","id":"23077255","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"24589551","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 61 |
| Details | Region: {"description":"Tudor-like domain 2","evidences":[{"source":"PubMed","id":"23077255","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"24589551","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 3 |
| Details | Site: {"description":"Histone H3K4me3 and H3R8me2a binding","evidences":[{"source":"PubMed","id":"23077255","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"24589551","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 1 |
| Details | Modified residue: {"description":"Phosphoserine; by AURKA","evidences":[{"source":"PubMed","id":"22258766","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI6 |
| Number of Residues | 1 |
| Details | Modified residue: {"description":"Phosphoserine; by AURKA","evidences":[{"source":"PubMed","id":"22258766","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"18669648","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"20068231","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"23186163","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI7 |
| Number of Residues | 1 |
| Details | Modified residue: {"description":"Citrulline; alternate","evidences":[{"source":"PubMed","id":"16567635","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI8 |
| Number of Residues | 1 |
| Details | Modified residue: {"description":"Phosphothreonine; by HASPIN and VRK1","evidences":[{"source":"PubMed","id":"15681610","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"16185088","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"31527692","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
