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4MZ4

Discovery of an Irreversible HCV NS5B Polymerase Inhibitor

Functional Information from GO Data
ChainGOidnamespacecontents
A0003723molecular_functionRNA binding
A0003968molecular_functionRNA-dependent RNA polymerase activity
A0039694biological_processviral RNA genome replication
B0003723molecular_functionRNA binding
B0003968molecular_functionRNA-dependent RNA polymerase activity
B0039694biological_processviral RNA genome replication
Functional Information from PDB Data
site_idAC1
Number of Residues18
DetailsBINDING SITE FOR RESIDUE 2F3 A 601
ChainResidue
APHE193
AMET414
ATYR415
AGLN446
AILE447
ATYR448
AHOH770
AHOH847
AHOH1060
AHOH1121
AARG200
AASN316
AASP318
AASP319
ACYS366
ALEU384
AGLY410
AASN411

site_idAC2
Number of Residues10
DetailsBINDING SITE FOR RESIDUE PO4 A 602
ChainResidue
AARG505
AVAL530
AARG531
ATHR532
AHOH799
AHOH844
AHOH931
AHOH978
AHOH1133
AHOH1141

site_idAC3
Number of Residues8
DetailsBINDING SITE FOR RESIDUE PO4 A 603
ChainResidue
APRO22
AARG401
AHOH907
AHOH930
AHOH1193
AHOH1228
AHOH1600
BARG114

site_idAC4
Number of Residues9
DetailsBINDING SITE FOR RESIDUE PO4 A 604
ChainResidue
AARG114
AHOH1191
AHOH1295
AHOH1318
AHOH1464
AHOH1494
AHOH1524
BGLY516
BARG517

site_idAC5
Number of Residues18
DetailsBINDING SITE FOR RESIDUE 2F3 B 601
ChainResidue
BPHE193
BARG200
BASN316
BASP318
BASP319
BCYS366
BLEU384
BGLY410
BASN411
BTYR415
BGLN446
BILE447
BTYR448
BHOH746
BHOH841
BHOH869
BHOH1080
BHOH1195

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues6
DetailsBINDING: BINDING => ECO:0000250|UniProtKB:P26663
ChainResidueDetails
AASP220
AASP318
AASP319
BASP220
BASP318
BASP319

site_idSWS_FT_FI2
Number of Residues4
DetailsMOD_RES: Phosphoserine; by host => ECO:0000250|UniProtKB:P26662
ChainResidueDetails
ASER29
ASER42
BSER29
BSER42

223532

PDB entries from 2024-08-07

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