4MYG

MAPK13, active form

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000165	biological_process	MAPK cascade
A	0000166	molecular_function	nucleotide binding
A	0004672	molecular_function	protein kinase activity
A	0004674	molecular_function	protein serine/threonine kinase activity
A	0004707	molecular_function	MAP kinase activity
A	0005515	molecular_function	protein binding
A	0005524	molecular_function	ATP binding
A	0005634	cellular_component	nucleus
A	0005737	cellular_component	cytoplasm
A	0005829	cellular_component	cytosol
A	0006351	biological_process	DNA-templated transcription
A	0006468	biological_process	protein phosphorylation
A	0006970	biological_process	response to osmotic stress
A	0016301	molecular_function	kinase activity
A	0016740	molecular_function	transferase activity
A	0032755	biological_process	positive regulation of interleukin-6 production
A	0033554	biological_process	cellular response to stress
A	0034644	biological_process	cellular response to UV
A	0035556	biological_process	intracellular signal transduction
A	0050729	biological_process	positive regulation of inflammatory response
A	0051403	biological_process	stress-activated MAPK cascade
A	0070301	biological_process	cellular response to hydrogen peroxide
A	0071347	biological_process	cellular response to interleukin-1
A	0072709	biological_process	cellular response to sorbitol
A	0072740	biological_process	cellular response to anisomycin
A	0106310	molecular_function	protein serine kinase activity
A	1903936	biological_process	cellular response to sodium arsenite
B	0000165	biological_process	MAPK cascade
B	0000166	molecular_function	nucleotide binding
B	0004672	molecular_function	protein kinase activity
B	0004674	molecular_function	protein serine/threonine kinase activity
B	0004707	molecular_function	MAP kinase activity
B	0005515	molecular_function	protein binding
B	0005524	molecular_function	ATP binding
B	0005634	cellular_component	nucleus
B	0005737	cellular_component	cytoplasm
B	0005829	cellular_component	cytosol
B	0006351	biological_process	DNA-templated transcription
B	0006468	biological_process	protein phosphorylation
B	0006970	biological_process	response to osmotic stress
B	0016301	molecular_function	kinase activity
B	0016740	molecular_function	transferase activity
B	0032755	biological_process	positive regulation of interleukin-6 production
B	0033554	biological_process	cellular response to stress
B	0034644	biological_process	cellular response to UV
B	0035556	biological_process	intracellular signal transduction
B	0050729	biological_process	positive regulation of inflammatory response
B	0051403	biological_process	stress-activated MAPK cascade
B	0070301	biological_process	cellular response to hydrogen peroxide
B	0071347	biological_process	cellular response to interleukin-1
B	0072709	biological_process	cellular response to sorbitol
B	0072740	biological_process	cellular response to anisomycin
B	0106310	molecular_function	protein serine kinase activity
B	1903936	biological_process	cellular response to sodium arsenite

Functional Information from PROSITE/UniProt

site_id	PS00107
Number of Residues	25
Details	PROTEIN_KINASE_ATP Protein kinases ATP-binding region signature. VGSGAYGSVCsAidkrsgekv.........AIKK

Chain	Residue	Details
A	VAL31-LYS55

---

site_id	PS01351
Number of Residues	103
Details	MAPK MAP kinase signature. FqseifakrayREllllkhmqhenviglldvftpasslrnfydfylvmpfmqtdlqkimgmefseekiqylvyqmlkglkyihsagvvh..........RDlKpgnlavnedC

Chain	Residue	Details
A	PHE60-CYS162

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	4
Details	Motif: {"description":"TXY"}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	2
Details	Active site: {"description":"Proton acceptor","evidences":[{"source":"PROSITE-ProRule","id":"PRU00159","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	18
Details	Binding site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU00159","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	2
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"18088087","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	2
Details	Modified residue: {"description":"Phosphothreonine; by MAP2K3, MAP2K4, MAP2K6 and MAP2K7","evidences":[{"source":"PubMed","id":"9374491","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI6
Number of Residues	2
Details	Modified residue: {"description":"Phosphotyrosine; by MAP2K3, MAP2K4, MAP2K6 and MAP2K7","evidences":[{"source":"PubMed","id":"9374491","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---