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4MXY

Src M314L T338M double mutant bound to kinase inhibitor bosutinib

Functional Information from GO Data
ChainGOidnamespacecontents
A0004672molecular_functionprotein kinase activity
A0004713molecular_functionprotein tyrosine kinase activity
A0005524molecular_functionATP binding
A0006468biological_processprotein phosphorylation
B0004672molecular_functionprotein kinase activity
B0004713molecular_functionprotein tyrosine kinase activity
B0005524molecular_functionATP binding
B0006468biological_processprotein phosphorylation
Functional Information from PDB Data
site_idAC1
Number of Residues11
DetailsBINDING SITE FOR RESIDUE DB8 A 601
ChainResidue
AALA293
ASER342
ALEU393
ALYS295
AGLU310
AVAL323
AILE336
AMET338
AGLU339
ATYR340
AMET341

site_idAC2
Number of Residues13
DetailsBINDING SITE FOR RESIDUE DB8 B 601
ChainResidue
BLEU273
BALA293
BILE294
BLYS295
BGLU310
BVAL323
BILE336
BMET338
BGLU339
BTYR340
BMET341
BGLY344
BLEU393

Functional Information from PROSITE/UniProt
site_idPS00107
Number of Residues23
DetailsPROTEIN_KINASE_ATP Protein kinases ATP-binding region signature. LGQGCFGEVWmGtwngttr...........VAIK
ChainResidueDetails
ALEU273-LYS295

site_idPS00109
Number of Residues13
DetailsPROTEIN_KINASE_TYR Tyrosine protein kinases specific active-site signature. YVHrDLRAANILV
ChainResidueDetails
ATYR382-VAL394

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues2
DetailsACT_SITE: Proton acceptor
ChainResidueDetails
AASP386
BASP386

site_idSWS_FT_FI2
Number of Residues4
DetailsBINDING:
ChainResidueDetails
BLEU273
BLYS295
ALEU273
ALYS295

site_idSWS_FT_FI3
Number of Residues2
DetailsMOD_RES: Phosphotyrosine; by FAK2 => ECO:0000250
ChainResidueDetails
ATYR416
BTYR416

site_idSWS_FT_FI4
Number of Residues2
DetailsMOD_RES: Phosphotyrosine; by CSK => ECO:0000269|PubMed:19307596, ECO:0000269|PubMed:26936507, ECO:0000269|PubMed:7525268, ECO:0000269|PubMed:7929427, ECO:0007744|PubMed:19369195
ChainResidueDetails
ATYR527
BTYR527

221051

PDB entries from 2024-06-12

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