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4MXX

Human Src A403T mutant bound to kinase inhibitor bosutinib

Functional Information from GO Data
ChainGOidnamespacecontents
A0004672molecular_functionprotein kinase activity
A0004713molecular_functionprotein tyrosine kinase activity
A0005524molecular_functionATP binding
A0006468biological_processprotein phosphorylation
B0004672molecular_functionprotein kinase activity
B0004713molecular_functionprotein tyrosine kinase activity
B0005524molecular_functionATP binding
B0006468biological_processprotein phosphorylation
Functional Information from PDB Data
site_idAC1
Number of Residues15
DetailsBINDING SITE FOR RESIDUE DB8 A 601
ChainResidue
ALEU273
ATYR340
AMET341
ASER342
ALYS343
ALEU393
ATHR403
AALA293
ALYS295
AGLU310
AMET314
AVAL323
AILE336
ATHR338
AGLU339

site_idAC2
Number of Residues13
DetailsBINDING SITE FOR RESIDUE DB8 B 601
ChainResidue
BLEU273
BALA293
BLYS295
BILE336
BTHR338
BGLU339
BTYR340
BMET341
BSER342
BGLY344
BLEU393
BTHR403
BPHE405

Functional Information from PROSITE/UniProt
site_idPS00107
Number of Residues23
DetailsPROTEIN_KINASE_ATP Protein kinases ATP-binding region signature. LGQGCFGEVWmGtwngttr...........VAIK
ChainResidueDetails
ALEU273-LYS295

site_idPS00109
Number of Residues13
DetailsPROTEIN_KINASE_TYR Tyrosine protein kinases specific active-site signature. YVHrDLRAANILV
ChainResidueDetails
ATYR382-VAL394

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues2
DetailsActive site: {"description":"Proton acceptor","evidences":[{"source":"PROSITE-ProRule","id":"PRU00159","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails

site_idSWS_FT_FI2
Number of Residues18
DetailsBinding site: {}
ChainResidueDetails

site_idSWS_FT_FI3
Number of Residues2
DetailsModified residue: {"description":"Phosphotyrosine; by CSK","evidences":[{"source":"PubMed","id":"19307596","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"26936507","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"7525268","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"7929427","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"19369195","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails

239149

PDB entries from 2025-07-23

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