4MXX
Human Src A403T mutant bound to kinase inhibitor bosutinib
Functional Information from GO Data
Chain | GOid | namespace | contents |
A | 0004672 | molecular_function | protein kinase activity |
A | 0004713 | molecular_function | protein tyrosine kinase activity |
A | 0005524 | molecular_function | ATP binding |
A | 0006468 | biological_process | protein phosphorylation |
B | 0004672 | molecular_function | protein kinase activity |
B | 0004713 | molecular_function | protein tyrosine kinase activity |
B | 0005524 | molecular_function | ATP binding |
B | 0006468 | biological_process | protein phosphorylation |
Functional Information from PDB Data
site_id | AC1 |
Number of Residues | 15 |
Details | BINDING SITE FOR RESIDUE DB8 A 601 |
Chain | Residue |
A | LEU273 |
A | TYR340 |
A | MET341 |
A | SER342 |
A | LYS343 |
A | LEU393 |
A | THR403 |
A | ALA293 |
A | LYS295 |
A | GLU310 |
A | MET314 |
A | VAL323 |
A | ILE336 |
A | THR338 |
A | GLU339 |
site_id | AC2 |
Number of Residues | 13 |
Details | BINDING SITE FOR RESIDUE DB8 B 601 |
Chain | Residue |
B | LEU273 |
B | ALA293 |
B | LYS295 |
B | ILE336 |
B | THR338 |
B | GLU339 |
B | TYR340 |
B | MET341 |
B | SER342 |
B | GLY344 |
B | LEU393 |
B | THR403 |
B | PHE405 |
Functional Information from PROSITE/UniProt
site_id | PS00107 |
Number of Residues | 23 |
Details | PROTEIN_KINASE_ATP Protein kinases ATP-binding region signature. LGQGCFGEVWmGtwngttr...........VAIK |
Chain | Residue | Details |
A | LEU273-LYS295 |
site_id | PS00109 |
Number of Residues | 13 |
Details | PROTEIN_KINASE_TYR Tyrosine protein kinases specific active-site signature. YVHrDLRAANILV |
Chain | Residue | Details |
A | TYR382-VAL394 |
Functional Information from SwissProt/UniProt
site_id | SWS_FT_FI1 |
Number of Residues | 2 |
Details | Active site: {"description":"Proton acceptor","evidences":[{"source":"PROSITE-ProRule","id":"PRU00159","evidenceCode":"ECO:0000255"}]} |
Chain | Residue | Details |
site_id | SWS_FT_FI2 |
Number of Residues | 18 |
Details | Binding site: {} |
Chain | Residue | Details |
site_id | SWS_FT_FI3 |
Number of Residues | 2 |
Details | Modified residue: {"description":"Phosphotyrosine; by CSK","evidences":[{"source":"PubMed","id":"19307596","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"26936507","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"7525268","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"7929427","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"19369195","evidenceCode":"ECO:0007744"}]} |
Chain | Residue | Details |