4MWE
Trypanosoma brucei methionyl-tRNA synthetase in complex with inhibitor 1-(3-{[5-chloro-3-(prop-2-en-1-yl)-2-(prop-2-en-1-yloxy)benzyl]amino}propyl)-3-thiophen-3-ylurea (Chem 1475)
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0000166 | molecular_function | nucleotide binding |
| A | 0004812 | molecular_function | aminoacyl-tRNA ligase activity |
| A | 0004825 | molecular_function | methionine-tRNA ligase activity |
| A | 0005524 | molecular_function | ATP binding |
| A | 0006418 | biological_process | tRNA aminoacylation for protein translation |
| A | 0006431 | biological_process | methionyl-tRNA aminoacylation |
| B | 0000166 | molecular_function | nucleotide binding |
| B | 0004812 | molecular_function | aminoacyl-tRNA ligase activity |
| B | 0004825 | molecular_function | methionine-tRNA ligase activity |
| B | 0005524 | molecular_function | ATP binding |
| B | 0006418 | biological_process | tRNA aminoacylation for protein translation |
| B | 0006431 | biological_process | methionyl-tRNA aminoacylation |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE GOL A 801 |
| Chain | Residue |
| A | GLU343 |
| A | LEU344 |
| A | LYS347 |
| A | LEU482 |
| A | ARG486 |
| site_id | AC2 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE GOL A 802 |
| Chain | Residue |
| A | ARG583 |
| A | ARG601 |
| site_id | AC3 |
| Number of Residues | 8 |
| Details | BINDING SITE FOR RESIDUE GOL A 803 |
| Chain | Residue |
| A | HIS545 |
| A | PHE587 |
| A | PRO659 |
| A | ASP660 |
| A | ILE661 |
| A | GLN662 |
| A | TYR261 |
| A | ILE265 |
| site_id | AC4 |
| Number of Residues | 1 |
| Details | BINDING SITE FOR RESIDUE GOL A 804 |
| Chain | Residue |
| A | ASP446 |
| site_id | AC5 |
| Number of Residues | 1 |
| Details | BINDING SITE FOR RESIDUE DMS A 805 |
| Chain | Residue |
| A | LYS521 |
| site_id | AC6 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE DMS A 806 |
| Chain | Residue |
| A | GLU392 |
| A | LYS517 |
| A | ASP518 |
| A | ILE519 |
| A | LEU520 |
| A | LYS521 |
| site_id | AC7 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE DMS A 807 |
| Chain | Residue |
| A | PHE370 |
| A | LYS521 |
| A | TYR526 |
| site_id | AC8 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE SO4 A 808 |
| Chain | Residue |
| A | ARG271 |
| A | VAL275 |
| A | SER714 |
| site_id | AC9 |
| Number of Residues | 11 |
| Details | BINDING SITE FOR RESIDUE MET A 809 |
| Chain | Residue |
| A | ILE248 |
| A | TYR249 |
| A | TYR250 |
| A | ASP287 |
| A | TRP474 |
| A | ALA477 |
| A | TYR481 |
| A | HIS523 |
| A | THR549 |
| A | LYS550 |
| A | HOH952 |
| site_id | BC1 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE GOL B 801 |
| Chain | Residue |
| B | LEU344 |
| B | ARG486 |
| site_id | BC2 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE GOL B 802 |
| Chain | Residue |
| B | ARG583 |
| B | ARG601 |
| site_id | BC3 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE GOL B 803 |
| Chain | Residue |
| A | TYR305 |
| B | HIS289 |
| B | LYS338 |
| B | ALA460 |
| site_id | BC4 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE GOL B 804 |
| Chain | Residue |
| B | ARG408 |
| B | GLU739 |
| B | HOH973 |
| B | HOH1033 |
| B | HOH1034 |
| B | HOH1035 |
| site_id | BC5 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE DMS B 805 |
| Chain | Residue |
| B | TYR324 |
| B | ILE326 |
| B | HOH917 |
| site_id | BC6 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE SO4 B 806 |
| Chain | Residue |
| B | ARG271 |
| B | VAL275 |
| B | SER714 |
| B | PRO718 |
| B | HOH901 |
| site_id | BC7 |
| Number of Residues | 13 |
| Details | BINDING SITE FOR RESIDUE 2EN B 807 |
| Chain | Residue |
| B | ILE248 |
| B | TYR250 |
| B | ASP287 |
| B | HIS289 |
| B | GLY290 |
| B | TYR472 |
| B | VAL473 |
| B | TRP474 |
| B | ASP476 |
| B | LEU478 |
| B | TYR481 |
| B | PHE522 |
| B | HIS523 |
