4MW7
Trypanosoma brucei methionyl-tRNA synthetase in complex with inhibitor 1-{3-[(5-chloro-2-ethoxy-3-iodobenzyl)amino]propyl}-3-thiophen-3-ylurea (Chem 1469)
Functional Information from GO Data
Chain | GOid | namespace | contents |
A | 0000166 | molecular_function | nucleotide binding |
A | 0004812 | molecular_function | aminoacyl-tRNA ligase activity |
A | 0004825 | molecular_function | methionine-tRNA ligase activity |
A | 0005524 | molecular_function | ATP binding |
A | 0006418 | biological_process | tRNA aminoacylation for protein translation |
A | 0006431 | biological_process | methionyl-tRNA aminoacylation |
B | 0000166 | molecular_function | nucleotide binding |
B | 0004812 | molecular_function | aminoacyl-tRNA ligase activity |
B | 0004825 | molecular_function | methionine-tRNA ligase activity |
B | 0005524 | molecular_function | ATP binding |
B | 0006418 | biological_process | tRNA aminoacylation for protein translation |
B | 0006431 | biological_process | methionyl-tRNA aminoacylation |
Functional Information from PDB Data
site_id | AC1 |
Number of Residues | 4 |
Details | BINDING SITE FOR RESIDUE GOL A 801 |
Chain | Residue |
A | ARG271 |
A | VAL275 |
A | PRO718 |
A | VAL722 |
site_id | AC2 |
Number of Residues | 7 |
Details | BINDING SITE FOR RESIDUE GOL A 802 |
Chain | Residue |
A | ILE661 |
A | GLN662 |
A | ILE265 |
A | SER585 |
A | GLY586 |
A | PHE587 |
A | PRO659 |
site_id | AC3 |
Number of Residues | 5 |
Details | BINDING SITE FOR RESIDUE GOL A 803 |
Chain | Residue |
A | TRP345 |
A | GLU349 |
A | TYR405 |
A | PRO464 |
A | GLY465 |
site_id | AC4 |
Number of Residues | 2 |
Details | BINDING SITE FOR RESIDUE GOL A 804 |
Chain | Residue |
A | ARG583 |
A | ARG601 |
site_id | AC5 |
Number of Residues | 3 |
Details | BINDING SITE FOR RESIDUE GOL A 805 |
Chain | Residue |
A | PRO731 |
A | GLU732 |
A | VAL733 |
site_id | AC6 |
Number of Residues | 5 |
Details | BINDING SITE FOR RESIDUE GOL A 806 |
Chain | Residue |
A | GLY573 |
A | TYR574 |
A | ASP575 |
A | ALA576 |
A | LYS720 |
site_id | AC7 |
Number of Residues | 5 |
Details | BINDING SITE FOR RESIDUE GOL A 807 |
Chain | Residue |
A | GLU343 |
A | LEU344 |
A | ARG486 |
A | ASP500 |
A | PHE502 |
site_id | AC8 |
Number of Residues | 7 |
Details | BINDING SITE FOR RESIDUE GOL A 808 |
Chain | Residue |
A | ASN252 |
A | HIS256 |
A | LYS292 |
A | SER366 |
A | HIS395 |
A | LYS550 |
A | ASP551 |
site_id | AC9 |
Number of Residues | 5 |
Details | BINDING SITE FOR RESIDUE DMS A 809 |
Chain | Residue |
A | GLU392 |
A | LYS517 |
A | ASP518 |
A | ILE519 |
A | LEU520 |
site_id | BC1 |
Number of Residues | 1 |
Details | BINDING SITE FOR RESIDUE DMS A 810 |
Chain | Residue |
A | HOH961 |
site_id | BC2 |
Number of Residues | 2 |
Details | BINDING SITE FOR RESIDUE DMS A 811 |
Chain | Residue |
A | PHE370 |
A | TYR526 |
site_id | BC3 |
Number of Residues | 3 |
Details | BINDING SITE FOR RESIDUE DMS A 812 |
Chain | Residue |
A | PHE319 |
A | GLU320 |
A | ILE326 |
site_id | BC4 |
Number of Residues | 11 |
Details | BINDING SITE FOR RESIDUE MET A 813 |
Chain | Residue |
A | ILE248 |
A | TYR250 |
A | ASP287 |
A | TRP474 |
A | ALA477 |
A | TYR481 |
A | ILE519 |
A | HIS523 |
A | THR549 |
A | LYS550 |
A | HOH944 |
site_id | BC5 |
Number of Residues | 3 |
Details | BINDING SITE FOR RESIDUE GOL B 801 |
Chain | Residue |
B | GLU343 |
B | LEU344 |
B | ARG486 |
site_id | BC6 |
Number of Residues | 2 |
Details | BINDING SITE FOR RESIDUE GOL B 802 |
Chain | Residue |
B | ARG583 |
B | ARG601 |
site_id | BC7 |
Number of Residues | 6 |
Details | BINDING SITE FOR RESIDUE GOL B 803 |
Chain | Residue |
A | TYR305 |
B | HIS289 |
B | LYS338 |
B | ASN458 |
B | ALA460 |
B | CAS470 |
site_id | BC8 |
Number of Residues | 3 |
Details | BINDING SITE FOR RESIDUE DMS B 804 |
Chain | Residue |
B | GLU320 |
B | TYR324 |
B | ILE326 |
site_id | BC9 |
Number of Residues | 4 |
Details | BINDING SITE FOR RESIDUE SO4 B 805 |
Chain | Residue |
B | TYR249 |
B | TYR250 |
B | HIS259 |
B | 2EF806 |
site_id | CC1 |
Number of Residues | 16 |
Details | BINDING SITE FOR RESIDUE 2EF B 806 |
Chain | Residue |
B | PRO247 |
B | ILE248 |
B | TYR250 |
B | ASP287 |
B | HIS289 |
B | GLY290 |
B | TYR472 |
B | VAL473 |
B | TRP474 |
B | ASP476 |
B | TYR481 |
B | ILE519 |
B | PHE522 |
B | HIS523 |
B | SO4805 |
B | HOH999 |