4MW5
Trypanosoma brucei methionyl-tRNA synthetase in complex with inhibitor 1-{3-[(3-chloro-5-methoxybenzyl)amino]propyl}-3-phenylurea (Chem 1415)
Replaces: 3U1GFunctional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0000166 | molecular_function | nucleotide binding |
| A | 0004812 | molecular_function | aminoacyl-tRNA ligase activity |
| A | 0004825 | molecular_function | methionine-tRNA ligase activity |
| A | 0005524 | molecular_function | ATP binding |
| A | 0006418 | biological_process | tRNA aminoacylation for protein translation |
| A | 0006431 | biological_process | methionyl-tRNA aminoacylation |
| B | 0000166 | molecular_function | nucleotide binding |
| B | 0004812 | molecular_function | aminoacyl-tRNA ligase activity |
| B | 0004825 | molecular_function | methionine-tRNA ligase activity |
| B | 0005524 | molecular_function | ATP binding |
| B | 0006418 | biological_process | tRNA aminoacylation for protein translation |
| B | 0006431 | biological_process | methionyl-tRNA aminoacylation |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE GOL A 901 |
| Chain | Residue |
| A | ARG583 |
| A | ARG601 |
| site_id | AC2 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE GOL A 902 |
| Chain | Residue |
| A | ARG271 |
| A | VAL275 |
| A | SER714 |
| A | HOH1166 |
| site_id | AC3 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE GOL A 903 |
| Chain | Residue |
| A | HOH1058 |
| B | ARG358 |
| B | HIS654 |
| A | GLU639 |
| A | GLN643 |
| A | LYS646 |
| site_id | AC4 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE DMS A 904 |
| Chain | Residue |
| A | PHE370 |
| A | LYS521 |
| A | TYR526 |
| A | HOH1272 |
| site_id | AC5 |
| Number of Residues | 11 |
| Details | BINDING SITE FOR RESIDUE MET A 906 |
| Chain | Residue |
| A | ILE248 |
| A | TYR250 |
| A | ASP287 |
| A | TRP474 |
| A | ALA477 |
| A | TYR481 |
| A | ILE519 |
| A | HIS523 |
| A | HOH1185 |
| A | HOH1186 |
| A | HOH1234 |
| site_id | AC6 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE GOL B 901 |
| Chain | Residue |
| B | LYS347 |
| B | ARG486 |
| B | HOH1171 |
| site_id | AC7 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE GOL B 902 |
| Chain | Residue |
| B | ARG583 |
| B | ARG601 |
| site_id | AC8 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE GOL B 903 |
| Chain | Residue |
| B | HIS289 |
| B | THR333 |
| B | LYS338 |
| B | ASN458 |
| B | TRP459 |
| B | ALA460 |
| B | HOH1178 |
| site_id | AC9 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE GOL B 904 |
| Chain | Residue |
| B | ARG271 |
| B | VAL275 |
| B | PRO718 |
| B | SER721 |
| B | HOH1131 |
| B | HOH1247 |
| site_id | BC1 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE GOL B 905 |
| Chain | Residue |
| B | MET0 |
| B | GLU239 |
| B | TYR359 |
| B | PHE370 |
| B | MET406 |
| site_id | BC2 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE DMS B 906 |
| Chain | Residue |
| B | GLU320 |
| B | TYR324 |
| B | SER325 |
| B | ILE326 |
| B | HOH1053 |
| site_id | BC3 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE DMS B 907 |
| Chain | Residue |
| B | TYR472 |
| B | HOH1028 |
| site_id | BC4 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE SO4 B 908 |
| Chain | Residue |
| B | ARG408 |
| B | ARG415 |
| B | HOH1186 |
| B | HOH1210 |
| site_id | BC5 |
| Number of Residues | 15 |
| Details | BINDING SITE FOR RESIDUE 415 B 909 |
| Chain | Residue |
| B | ILE248 |
| B | TYR250 |
| B | ASP287 |
| B | HIS289 |
| B | GLY290 |
| B | VAL471 |
| B | TYR472 |
| B | VAL473 |
| B | TRP474 |
| B | ASP476 |
| B | LEU478 |
| B | ILE519 |
| B | PHE522 |
| B | HOH1014 |
| B | HOH1015 |
