4MW4
Trypanosoma brucei methionyl-tRNA synthetase in complex with inhibitor 1-{3-[(5-chloro-2-hydroxy-3-iodobenzyl)amino]propyl}-3-thiophen-3-ylurea (Chem 1473)
Functional Information from GO Data
Chain | GOid | namespace | contents |
A | 0000166 | molecular_function | nucleotide binding |
A | 0004812 | molecular_function | aminoacyl-tRNA ligase activity |
A | 0004825 | molecular_function | methionine-tRNA ligase activity |
A | 0005524 | molecular_function | ATP binding |
A | 0006418 | biological_process | tRNA aminoacylation for protein translation |
A | 0006431 | biological_process | methionyl-tRNA aminoacylation |
B | 0000166 | molecular_function | nucleotide binding |
B | 0004812 | molecular_function | aminoacyl-tRNA ligase activity |
B | 0004825 | molecular_function | methionine-tRNA ligase activity |
B | 0005524 | molecular_function | ATP binding |
B | 0006418 | biological_process | tRNA aminoacylation for protein translation |
B | 0006431 | biological_process | methionyl-tRNA aminoacylation |
Functional Information from PDB Data
site_id | AC1 |
Number of Residues | 2 |
Details | BINDING SITE FOR RESIDUE GOL A 901 |
Chain | Residue |
A | ARG583 |
A | ARG601 |
site_id | AC2 |
Number of Residues | 4 |
Details | BINDING SITE FOR RESIDUE GOL A 902 |
Chain | Residue |
A | TRP345 |
A | GLU349 |
A | PRO464 |
A | GLY465 |
site_id | AC3 |
Number of Residues | 4 |
Details | BINDING SITE FOR RESIDUE GOL A 903 |
Chain | Residue |
A | ALA460 |
A | HIS289 |
A | LYS338 |
A | TRP459 |
site_id | AC4 |
Number of Residues | 5 |
Details | BINDING SITE FOR RESIDUE GOL A 904 |
Chain | Residue |
A | GLY573 |
A | TYR574 |
A | ASP575 |
A | ALA576 |
A | LYS720 |
site_id | AC5 |
Number of Residues | 2 |
Details | BINDING SITE FOR RESIDUE DMS A 905 |
Chain | Residue |
A | LYS521 |
A | DMS906 |
site_id | AC6 |
Number of Residues | 6 |
Details | BINDING SITE FOR RESIDUE DMS A 906 |
Chain | Residue |
A | GLU392 |
A | ASP518 |
A | ILE519 |
A | LEU520 |
A | LYS521 |
A | DMS905 |
site_id | AC7 |
Number of Residues | 3 |
Details | BINDING SITE FOR RESIDUE DMS A 907 |
Chain | Residue |
A | PHE370 |
A | LYS521 |
A | TYR526 |
site_id | AC8 |
Number of Residues | 4 |
Details | BINDING SITE FOR RESIDUE SO4 A 908 |
Chain | Residue |
A | ARG271 |
A | VAL275 |
A | SER714 |
A | PRO718 |
site_id | AC9 |
Number of Residues | 10 |
Details | BINDING SITE FOR RESIDUE MET A 909 |
Chain | Residue |
A | ILE248 |
A | TYR250 |
A | ASP287 |
A | TRP474 |
A | ALA477 |
A | TYR481 |
A | ILE519 |
A | HIS523 |
A | THR549 |
A | LYS550 |
site_id | BC1 |
Number of Residues | 3 |
Details | BINDING SITE FOR RESIDUE GOL B 801 |
Chain | Residue |
B | GLU343 |
B | LYS347 |
B | ARG486 |
site_id | BC2 |
Number of Residues | 6 |
Details | BINDING SITE FOR RESIDUE GOL B 802 |
Chain | Residue |
B | HIS289 |
B | THR333 |
B | LYS338 |
B | TRP459 |
B | ALA460 |
B | CAS470 |
site_id | BC3 |
Number of Residues | 2 |
Details | BINDING SITE FOR RESIDUE GOL B 803 |
Chain | Residue |
B | ARG583 |
B | ARG601 |
site_id | BC4 |
Number of Residues | 5 |
Details | BINDING SITE FOR RESIDUE GOL B 804 |
Chain | Residue |
B | GLY573 |
B | TYR574 |
B | ASP575 |
B | ARG719 |
B | LYS720 |
site_id | BC5 |
Number of Residues | 5 |
Details | BINDING SITE FOR RESIDUE GOL B 805 |
Chain | Residue |
B | MET0 |
B | GLU239 |
B | TYR359 |
B | PHE370 |
B | HOH965 |
site_id | BC6 |
Number of Residues | 4 |
Details | BINDING SITE FOR RESIDUE DMS B 806 |
Chain | Residue |
B | GLU320 |
B | TYR324 |
B | SER325 |
B | ILE326 |
site_id | BC7 |
Number of Residues | 1 |
Details | BINDING SITE FOR RESIDUE DMS B 807 |
Chain | Residue |
B | TRP474 |
site_id | BC8 |
Number of Residues | 6 |
Details | BINDING SITE FOR RESIDUE SO4 B 808 |
Chain | Residue |
B | TYR249 |
B | TYR250 |
B | HIS259 |
B | 2EB810 |
B | HOH955 |
B | HOH1004 |
site_id | BC9 |
Number of Residues | 5 |
Details | BINDING SITE FOR RESIDUE SO4 B 809 |
Chain | Residue |
B | ARG271 |
B | VAL275 |
B | SER714 |
B | PRO718 |
B | HOH1043 |
site_id | CC1 |
Number of Residues | 17 |
Details | BINDING SITE FOR RESIDUE 2EB B 810 |
Chain | Residue |
B | PRO247 |
B | ILE248 |
B | TYR250 |
B | ASP287 |
B | HIS289 |
B | GLY290 |
B | TYR472 |
B | VAL473 |
B | TRP474 |
B | ASP476 |
B | ALA477 |
B | LEU478 |
B | TYR481 |
B | ILE519 |
B | SO4808 |
B | HOH955 |
B | HOH1044 |