4MW0
Trypanosoma brucei methionyl-tRNA synthetase in complex with inhibitor 1-{3-[(3,5-dichlorobenzyl)amino]propyl}-3-(2-hydroxyphenyl)urea (Chem 1392)
Replaces: 3U1FFunctional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0000166 | molecular_function | nucleotide binding |
| A | 0004812 | molecular_function | aminoacyl-tRNA ligase activity |
| A | 0004825 | molecular_function | methionine-tRNA ligase activity |
| A | 0005524 | molecular_function | ATP binding |
| A | 0006418 | biological_process | tRNA aminoacylation for protein translation |
| A | 0006431 | biological_process | methionyl-tRNA aminoacylation |
| B | 0000166 | molecular_function | nucleotide binding |
| B | 0004812 | molecular_function | aminoacyl-tRNA ligase activity |
| B | 0004825 | molecular_function | methionine-tRNA ligase activity |
| B | 0005524 | molecular_function | ATP binding |
| B | 0006418 | biological_process | tRNA aminoacylation for protein translation |
| B | 0006431 | biological_process | methionyl-tRNA aminoacylation |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE GOL A 901 |
| Chain | Residue |
| A | ARG583 |
| A | ARG601 |
| A | HOH1266 |
| site_id | AC2 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE GOL A 902 |
| Chain | Residue |
| A | HIS289 |
| A | LYS338 |
| A | ASN458 |
| A | TRP459 |
| A | ALA460 |
| A | CAS470 |
| site_id | AC3 |
| Number of Residues | 1 |
| Details | BINDING SITE FOR RESIDUE DMS A 903 |
| Chain | Residue |
| A | ILE525 |
| site_id | AC4 |
| Number of Residues | 11 |
| Details | BINDING SITE FOR RESIDUE MET A 904 |
| Chain | Residue |
| A | ILE248 |
| A | TYR250 |
| A | ASP287 |
| A | TRP474 |
| A | ALA477 |
| A | TYR481 |
| A | ILE519 |
| A | HIS523 |
| A | HOH1127 |
| A | HOH1129 |
| A | HOH1145 |
| site_id | AC5 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE GOL B 801 |
| Chain | Residue |
| B | GLU343 |
| B | ARG486 |
| B | LEU536 |
| B | HOH1014 |
| site_id | AC6 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE GOL B 802 |
| Chain | Residue |
| B | ARG583 |
| B | ARG601 |
| B | HOH1017 |
| site_id | AC7 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE GOL B 803 |
| Chain | Residue |
| B | ARG271 |
| B | SER714 |
| B | PRO718 |
| B | SER721 |
| B | HOH1023 |
| B | HOH1205 |
| B | HOH1206 |
| site_id | AC8 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE GOL B 804 |
| Chain | Residue |
| B | HIS289 |
| B | THR333 |
| B | LYS338 |
| B | ASN458 |
| B | TRP459 |
| B | ALA460 |
| site_id | AC9 |
| Number of Residues | 1 |
| Details | BINDING SITE FOR RESIDUE GOL B 805 |
| Chain | Residue |
| B | ARG719 |
| site_id | BC1 |
| Number of Residues | 9 |
| Details | BINDING SITE FOR RESIDUE GOL B 806 |
| Chain | Residue |
| B | MET0 |
| B | GLU239 |
| B | TYR359 |
| B | PHE370 |
| B | ASN404 |
| B | MET406 |
| B | SER448 |
| B | HOH1110 |
| B | HOH1180 |
| site_id | BC2 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE DMS B 807 |
| Chain | Residue |
| B | TYR472 |
| B | HOH911 |
| site_id | BC3 |
| Number of Residues | 16 |
| Details | BINDING SITE FOR RESIDUE 392 B 808 |
| Chain | Residue |
| B | ILE248 |
| B | TYR250 |
| B | ASP287 |
| B | HIS289 |
| B | GLY290 |
| B | VAL471 |
| B | TYR472 |
| B | VAL473 |
| B | TRP474 |
| B | ASP476 |
| B | ALA477 |
| B | TYR481 |
| B | HIS523 |
| B | HOH910 |
| B | HOH978 |
| B | HOH1066 |
