4MW0
Trypanosoma brucei methionyl-tRNA synthetase in complex with inhibitor 1-{3-[(3,5-dichlorobenzyl)amino]propyl}-3-(2-hydroxyphenyl)urea (Chem 1392)
Replaces: 3U1FFunctional Information from GO Data
Chain | GOid | namespace | contents |
A | 0000166 | molecular_function | nucleotide binding |
A | 0004812 | molecular_function | aminoacyl-tRNA ligase activity |
A | 0004825 | molecular_function | methionine-tRNA ligase activity |
A | 0005524 | molecular_function | ATP binding |
A | 0006418 | biological_process | tRNA aminoacylation for protein translation |
A | 0006431 | biological_process | methionyl-tRNA aminoacylation |
B | 0000166 | molecular_function | nucleotide binding |
B | 0004812 | molecular_function | aminoacyl-tRNA ligase activity |
B | 0004825 | molecular_function | methionine-tRNA ligase activity |
B | 0005524 | molecular_function | ATP binding |
B | 0006418 | biological_process | tRNA aminoacylation for protein translation |
B | 0006431 | biological_process | methionyl-tRNA aminoacylation |
Functional Information from PDB Data
site_id | AC1 |
Number of Residues | 3 |
Details | BINDING SITE FOR RESIDUE GOL A 901 |
Chain | Residue |
A | ARG583 |
A | ARG601 |
A | HOH1266 |
site_id | AC2 |
Number of Residues | 6 |
Details | BINDING SITE FOR RESIDUE GOL A 902 |
Chain | Residue |
A | HIS289 |
A | LYS338 |
A | ASN458 |
A | TRP459 |
A | ALA460 |
A | CAS470 |
site_id | AC3 |
Number of Residues | 1 |
Details | BINDING SITE FOR RESIDUE DMS A 903 |
Chain | Residue |
A | ILE525 |
site_id | AC4 |
Number of Residues | 11 |
Details | BINDING SITE FOR RESIDUE MET A 904 |
Chain | Residue |
A | ILE248 |
A | TYR250 |
A | ASP287 |
A | TRP474 |
A | ALA477 |
A | TYR481 |
A | ILE519 |
A | HIS523 |
A | HOH1127 |
A | HOH1129 |
A | HOH1145 |
site_id | AC5 |
Number of Residues | 4 |
Details | BINDING SITE FOR RESIDUE GOL B 801 |
Chain | Residue |
B | GLU343 |
B | ARG486 |
B | LEU536 |
B | HOH1014 |
site_id | AC6 |
Number of Residues | 3 |
Details | BINDING SITE FOR RESIDUE GOL B 802 |
Chain | Residue |
B | ARG583 |
B | ARG601 |
B | HOH1017 |
site_id | AC7 |
Number of Residues | 7 |
Details | BINDING SITE FOR RESIDUE GOL B 803 |
Chain | Residue |
B | ARG271 |
B | SER714 |
B | PRO718 |
B | SER721 |
B | HOH1023 |
B | HOH1205 |
B | HOH1206 |
site_id | AC8 |
Number of Residues | 6 |
Details | BINDING SITE FOR RESIDUE GOL B 804 |
Chain | Residue |
B | HIS289 |
B | THR333 |
B | LYS338 |
B | ASN458 |
B | TRP459 |
B | ALA460 |
site_id | AC9 |
Number of Residues | 1 |
Details | BINDING SITE FOR RESIDUE GOL B 805 |
Chain | Residue |
B | ARG719 |
site_id | BC1 |
Number of Residues | 9 |
Details | BINDING SITE FOR RESIDUE GOL B 806 |
Chain | Residue |
B | MET0 |
B | GLU239 |
B | TYR359 |
B | PHE370 |
B | ASN404 |
B | MET406 |
B | SER448 |
B | HOH1110 |
B | HOH1180 |
site_id | BC2 |
Number of Residues | 2 |
Details | BINDING SITE FOR RESIDUE DMS B 807 |
Chain | Residue |
B | TYR472 |
B | HOH911 |
site_id | BC3 |
Number of Residues | 16 |
Details | BINDING SITE FOR RESIDUE 392 B 808 |
Chain | Residue |
B | ILE248 |
B | TYR250 |
B | ASP287 |
B | HIS289 |
B | GLY290 |
B | VAL471 |
B | TYR472 |
B | VAL473 |
B | TRP474 |
B | ASP476 |
B | ALA477 |
B | TYR481 |
B | HIS523 |
B | HOH910 |
B | HOH978 |
B | HOH1066 |