4MVX
Trypanosoma brucei methionyl-tRNA synthetase in complex with inhibitor 1-{3-[(3,5-dichlorobenzyl)amino]propyl}-3-phenylurea (Chem 1356)
Replaces: 3TUNFunctional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0000166 | molecular_function | nucleotide binding |
| A | 0004812 | molecular_function | aminoacyl-tRNA ligase activity |
| A | 0004825 | molecular_function | methionine-tRNA ligase activity |
| A | 0005524 | molecular_function | ATP binding |
| A | 0006418 | biological_process | tRNA aminoacylation for protein translation |
| A | 0006431 | biological_process | methionyl-tRNA aminoacylation |
| B | 0000166 | molecular_function | nucleotide binding |
| B | 0004812 | molecular_function | aminoacyl-tRNA ligase activity |
| B | 0004825 | molecular_function | methionine-tRNA ligase activity |
| B | 0005524 | molecular_function | ATP binding |
| B | 0006418 | biological_process | tRNA aminoacylation for protein translation |
| B | 0006431 | biological_process | methionyl-tRNA aminoacylation |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE GOL A 801 |
| Chain | Residue |
| A | ARG583 |
| A | ARG601 |
| site_id | AC2 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE GOL A 802 |
| Chain | Residue |
| A | GLY573 |
| A | TYR574 |
| A | ASP575 |
| A | ALA576 |
| A | LYS720 |
| A | HOH968 |
| site_id | AC3 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE GOL A 803 |
| Chain | Residue |
| A | GLU349 |
| A | PRO464 |
| A | GLY465 |
| A | TRP345 |
| site_id | AC4 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE DMS A 804 |
| Chain | Residue |
| A | PHE370 |
| A | TYR526 |
| A | DMS806 |
| site_id | AC5 |
| Number of Residues | 1 |
| Details | BINDING SITE FOR RESIDUE DMS A 805 |
| Chain | Residue |
| A | DMS806 |
| site_id | AC6 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE DMS A 806 |
| Chain | Residue |
| A | LEU444 |
| A | ILE525 |
| A | DMS804 |
| A | DMS805 |
| A | HOH939 |
| site_id | AC7 |
| Number of Residues | 8 |
| Details | BINDING SITE FOR RESIDUE MET A 807 |
| Chain | Residue |
| A | ILE248 |
| A | TYR250 |
| A | ASP287 |
| A | TRP474 |
| A | TYR481 |
| A | ILE519 |
| A | HOH1059 |
| A | HOH1063 |
| site_id | AC8 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE GOL B 801 |
| Chain | Residue |
| B | GLU343 |
| B | LEU482 |
| B | ARG486 |
| B | HOH999 |
| site_id | AC9 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE GOL B 802 |
| Chain | Residue |
| B | ARG583 |
| B | ARG601 |
| site_id | BC1 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE GOL B 803 |
| Chain | Residue |
| B | ARG408 |
| B | VAL733 |
| B | HOH962 |
| B | HOH1055 |
| B | HOH1067 |
| site_id | BC2 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE GOL B 804 |
| Chain | Residue |
| B | GLY573 |
| B | TYR574 |
| B | ASP575 |
| B | ALA576 |
| B | ARG719 |
| B | LYS720 |
| site_id | BC3 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE GOL B 805 |
| Chain | Residue |
| A | TYR305 |
| B | HIS289 |
| B | THR333 |
| B | LYS338 |
| B | ASN458 |
| B | TRP459 |
| B | ALA460 |
| site_id | BC4 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE GOL B 806 |
| Chain | Residue |
| B | PRO464 |
| B | GLY465 |
| site_id | BC5 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE DMS B 807 |
| Chain | Residue |
| B | TYR472 |
| B | HOH1078 |
| site_id | BC6 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE DMS B 808 |
| Chain | Residue |
| B | PHE319 |
| B | GLU320 |
| B | TYR324 |
| B | ILE326 |
| site_id | BC7 |
| Number of Residues | 14 |
| Details | BINDING SITE FOR RESIDUE C13 B 809 |
| Chain | Residue |
| B | ILE248 |
| B | TYR250 |
| B | ASP287 |
| B | HIS289 |
| B | GLY290 |
| B | VAL471 |
| B | TYR472 |
| B | VAL473 |
| B | TRP474 |
| B | ASP476 |
| B | ALA477 |
| B | TYR481 |
| B | ILE519 |
| B | HIS523 |
