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4MVW

Trypanosoma brucei methionyl-tRNA synthetase in complex with inhibitor 1-{3-[(3,5-dichlorobenzyl)amino]propyl}-3-thiophen-3-ylurea (Chem 1433)

Replaces:  3U1Z
Functional Information from GO Data
ChainGOidnamespacecontents
A0000166molecular_functionnucleotide binding
A0004812molecular_functionaminoacyl-tRNA ligase activity
A0004825molecular_functionmethionine-tRNA ligase activity
A0005524molecular_functionATP binding
A0006418biological_processtRNA aminoacylation for protein translation
A0006431biological_processmethionyl-tRNA aminoacylation
B0000166molecular_functionnucleotide binding
B0004812molecular_functionaminoacyl-tRNA ligase activity
B0004825molecular_functionmethionine-tRNA ligase activity
B0005524molecular_functionATP binding
B0006418biological_processtRNA aminoacylation for protein translation
B0006431biological_processmethionyl-tRNA aminoacylation
Functional Information from PDB Data
site_idAC1
Number of Residues3
DetailsBINDING SITE FOR RESIDUE GOL A 801
ChainResidue
AARG271
AARG274
ASER714

site_idAC2
Number of Residues8
DetailsBINDING SITE FOR RESIDUE GOL A 802
ChainResidue
AILE661
AGLN662
AILE265
AHIS545
ASER585
AGLY586
APHE587
AASP660

site_idAC3
Number of Residues2
DetailsBINDING SITE FOR RESIDUE GOL A 803
ChainResidue
AARG583
AARG601

site_idAC4
Number of Residues7
DetailsBINDING SITE FOR RESIDUE GOL A 804
ChainResidue
AASP726
AGLY729
AVAL730
APRO731
AGLU732
AARG735
AHOH1011

site_idAC5
Number of Residues7
DetailsBINDING SITE FOR RESIDUE DMS A 805
ChainResidue
AGLU392
ALYS517
AASP518
AILE519
ALEU520
ALYS521
ADMS806

site_idAC6
Number of Residues3
DetailsBINDING SITE FOR RESIDUE DMS A 806
ChainResidue
ALYS521
ADMS805
ADMS807

site_idAC7
Number of Residues2
DetailsBINDING SITE FOR RESIDUE DMS A 807
ChainResidue
ALEU444
ADMS806

site_idAC8
Number of Residues6
DetailsBINDING SITE FOR RESIDUE MET A 808
ChainResidue
AILE248
ATYR250
AASP287
ATRP474
ALYS550
AHOH999

site_idAC9
Number of Residues4
DetailsBINDING SITE FOR RESIDUE DMS B 801
ChainResidue
BGLU320
BTYR324
BSER325
BILE326

site_idBC1
Number of Residues4
DetailsBINDING SITE FOR RESIDUE GOL B 802
ChainResidue
BGLU343
BLEU482
BARG486
BHOH984

site_idBC2
Number of Residues2
DetailsBINDING SITE FOR RESIDUE GOL B 803
ChainResidue
BARG583
BARG601

site_idBC3
Number of Residues5
DetailsBINDING SITE FOR RESIDUE GOL B 804
ChainResidue
BHIS289
BLYS338
BASN458
BTRP459
BALA460

site_idBC4
Number of Residues1
DetailsBINDING SITE FOR RESIDUE DMS B 805
ChainResidue
B43E807

site_idBC5
Number of Residues5
DetailsBINDING SITE FOR RESIDUE SO4 B 806
ChainResidue
BARG271
BVAL275
BSER714
BPRO718
BHOH903

site_idBC6
Number of Residues15
DetailsBINDING SITE FOR RESIDUE 43E B 807
ChainResidue
BILE248
BTYR250
BASP287
BHIS289
BVAL471
BVAL473
BTRP474
BASP476
BALA477
BLEU478
BTYR481
BHIS523
BDMS805
BHOH910
BHOH1016

226707

PDB entries from 2024-10-30

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