4MVW
Trypanosoma brucei methionyl-tRNA synthetase in complex with inhibitor 1-{3-[(3,5-dichlorobenzyl)amino]propyl}-3-thiophen-3-ylurea (Chem 1433)
Replaces: 3U1ZFunctional Information from GO Data
Chain | GOid | namespace | contents |
A | 0000166 | molecular_function | nucleotide binding |
A | 0004812 | molecular_function | aminoacyl-tRNA ligase activity |
A | 0004825 | molecular_function | methionine-tRNA ligase activity |
A | 0005524 | molecular_function | ATP binding |
A | 0006418 | biological_process | tRNA aminoacylation for protein translation |
A | 0006431 | biological_process | methionyl-tRNA aminoacylation |
B | 0000166 | molecular_function | nucleotide binding |
B | 0004812 | molecular_function | aminoacyl-tRNA ligase activity |
B | 0004825 | molecular_function | methionine-tRNA ligase activity |
B | 0005524 | molecular_function | ATP binding |
B | 0006418 | biological_process | tRNA aminoacylation for protein translation |
B | 0006431 | biological_process | methionyl-tRNA aminoacylation |
Functional Information from PDB Data
site_id | AC1 |
Number of Residues | 3 |
Details | BINDING SITE FOR RESIDUE GOL A 801 |
Chain | Residue |
A | ARG271 |
A | ARG274 |
A | SER714 |
site_id | AC2 |
Number of Residues | 8 |
Details | BINDING SITE FOR RESIDUE GOL A 802 |
Chain | Residue |
A | ILE661 |
A | GLN662 |
A | ILE265 |
A | HIS545 |
A | SER585 |
A | GLY586 |
A | PHE587 |
A | ASP660 |
site_id | AC3 |
Number of Residues | 2 |
Details | BINDING SITE FOR RESIDUE GOL A 803 |
Chain | Residue |
A | ARG583 |
A | ARG601 |
site_id | AC4 |
Number of Residues | 7 |
Details | BINDING SITE FOR RESIDUE GOL A 804 |
Chain | Residue |
A | ASP726 |
A | GLY729 |
A | VAL730 |
A | PRO731 |
A | GLU732 |
A | ARG735 |
A | HOH1011 |
site_id | AC5 |
Number of Residues | 7 |
Details | BINDING SITE FOR RESIDUE DMS A 805 |
Chain | Residue |
A | GLU392 |
A | LYS517 |
A | ASP518 |
A | ILE519 |
A | LEU520 |
A | LYS521 |
A | DMS806 |
site_id | AC6 |
Number of Residues | 3 |
Details | BINDING SITE FOR RESIDUE DMS A 806 |
Chain | Residue |
A | LYS521 |
A | DMS805 |
A | DMS807 |
site_id | AC7 |
Number of Residues | 2 |
Details | BINDING SITE FOR RESIDUE DMS A 807 |
Chain | Residue |
A | LEU444 |
A | DMS806 |
site_id | AC8 |
Number of Residues | 6 |
Details | BINDING SITE FOR RESIDUE MET A 808 |
Chain | Residue |
A | ILE248 |
A | TYR250 |
A | ASP287 |
A | TRP474 |
A | LYS550 |
A | HOH999 |
site_id | AC9 |
Number of Residues | 4 |
Details | BINDING SITE FOR RESIDUE DMS B 801 |
Chain | Residue |
B | GLU320 |
B | TYR324 |
B | SER325 |
B | ILE326 |
site_id | BC1 |
Number of Residues | 4 |
Details | BINDING SITE FOR RESIDUE GOL B 802 |
Chain | Residue |
B | GLU343 |
B | LEU482 |
B | ARG486 |
B | HOH984 |
site_id | BC2 |
Number of Residues | 2 |
Details | BINDING SITE FOR RESIDUE GOL B 803 |
Chain | Residue |
B | ARG583 |
B | ARG601 |
site_id | BC3 |
Number of Residues | 5 |
Details | BINDING SITE FOR RESIDUE GOL B 804 |
Chain | Residue |
B | HIS289 |
B | LYS338 |
B | ASN458 |
B | TRP459 |
B | ALA460 |
site_id | BC4 |
Number of Residues | 1 |
Details | BINDING SITE FOR RESIDUE DMS B 805 |
Chain | Residue |
B | 43E807 |
site_id | BC5 |
Number of Residues | 5 |
Details | BINDING SITE FOR RESIDUE SO4 B 806 |
Chain | Residue |
B | ARG271 |
B | VAL275 |
B | SER714 |
B | PRO718 |
B | HOH903 |
site_id | BC6 |
Number of Residues | 15 |
Details | BINDING SITE FOR RESIDUE 43E B 807 |
Chain | Residue |
B | ILE248 |
B | TYR250 |
B | ASP287 |
B | HIS289 |
B | VAL471 |
B | VAL473 |
B | TRP474 |
B | ASP476 |
B | ALA477 |
B | LEU478 |
B | TYR481 |
B | HIS523 |
B | DMS805 |
B | HOH910 |
B | HOH1016 |