4MUR

Crystal structure of vancomycin resistance D,D-dipeptidase/D,D-pentapeptidase VanXYc D59S mutant

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003824	molecular_function	catalytic activity
A	0004180	molecular_function	carboxypeptidase activity
A	0005737	cellular_component	cytoplasm
A	0006508	biological_process	proteolysis
A	0008233	molecular_function	peptidase activity
A	0016787	molecular_function	hydrolase activity
A	0046677	biological_process	response to antibiotic
A	0046872	molecular_function	metal ion binding
A	0160237	molecular_function	D-Ala-D-Ala dipeptidase activity
B	0003824	molecular_function	catalytic activity
B	0004180	molecular_function	carboxypeptidase activity
B	0005737	cellular_component	cytoplasm
B	0006508	biological_process	proteolysis
B	0008233	molecular_function	peptidase activity
B	0016787	molecular_function	hydrolase activity
B	0046677	biological_process	response to antibiotic
B	0046872	molecular_function	metal ion binding
B	0160237	molecular_function	D-Ala-D-Ala dipeptidase activity

Functional Information from PDB Data

site_id	AC1
Number of Residues	5
Details	BINDING SITE FOR RESIDUE ZN A 201

Chain	Residue
A	HIS95
A	ASP102
A	HIS156
A	HOH383
A	HOH465

---

site_id	AC2
Number of Residues	4
Details	BINDING SITE FOR RESIDUE CL A 202

Chain	Residue
A	GLN67
A	ALA88
A	SER93
A	HOH598

---

site_id	AC3
Number of Residues	3
Details	BINDING SITE FOR RESIDUE CL A 203

Chain	Residue
A	ARG69
A	HOH528
B	LEU22

---

site_id	AC4
Number of Residues	4
Details	BINDING SITE FOR RESIDUE CL A 204

Chain	Residue
A	ASN8
A	ASN10
A	HIS11
A	HOH470

---

site_id	AC5
Number of Residues	1
Details	BINDING SITE FOR RESIDUE PE3 A 205

Chain	Residue
A	HIS179

---

site_id	AC6
Number of Residues	5
Details	BINDING SITE FOR RESIDUE PE3 A 206

Chain	Residue
A	MET1
A	ASN2
A	GLN5
A	LYS14
A	GLN17

---

site_id	AC7
Number of Residues	4
Details	BINDING SITE FOR RESIDUE PE3 A 207

Chain	Residue
A	GLU37
A	LYS40
A	GLN41
A	ARG44

---

site_id	AC8
Number of Residues	4
Details	BINDING SITE FOR RESIDUE PE3 A 208

Chain	Residue
A	PHE189
B	HIS179
B	ALA183
B	HOH574

---

site_id	AC9
Number of Residues	5
Details	BINDING SITE FOR RESIDUE ZN B 201

Chain	Residue
B	HIS95
B	ASP102
B	HIS156
B	HOH353
B	HOH385

---

site_id	BC1
Number of Residues	7
Details	BINDING SITE FOR RESIDUE SO4 B 202

Chain	Residue
A	ARG119
B	LYS65
B	ARG68
B	ARG69
B	HOH411
B	HOH480
B	HOH563

---

site_id	BC2
Number of Residues	3
Details	BINDING SITE FOR RESIDUE CL B 203

Chain	Residue
B	GLN67
B	ALA88
B	HOH583

---

site_id	BC3
Number of Residues	4
Details	BINDING SITE FOR RESIDUE CL B 204

Chain	Residue
A	HIS21
A	LEU22
A	HOH580
B	ARG69

---

site_id	BC4
Number of Residues	3
Details	BINDING SITE FOR RESIDUE CL B 205

Chain	Residue
A	HOH538
B	THR63
B	HOH436

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	2
Details	Active site: {"description":"catalytic acid/base residue","evidences":[{"source":"PubMed","id":"24711382","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	2
Details	Binding site: {"evidences":[{"source":"PDB","id":"4OAK","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	8
Details	Binding site: {"evidences":[{"source":"PubMed","id":"24711382","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"4OAK","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	6
Details	Binding site: {"evidences":[{"source":"PDB","id":"4MUR","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4MUS","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---