4MUH
Crystal structure of pantothenate synthetase in complex with 2-(2-(5-acetamido-1,3,4-thiadiazol-2-ylsulfonylcarbamoyl)-5-methoxy-1H-indol-1-yl)acetic acid
Functional Information from GO Data
Functional Information from PDB Data
site_id | AC1 |
Number of Residues | 5 |
Details | BINDING SITE FOR RESIDUE EOH A 401 |
Chain | Residue |
A | ARG115 |
A | THR117 |
A | HOH602 |
B | GLN119 |
B | PRO120 |
site_id | AC2 |
Number of Residues | 3 |
Details | BINDING SITE FOR RESIDUE EOH A 402 |
Chain | Residue |
A | THR218 |
B | HIS222 |
B | THR225 |
site_id | AC3 |
Number of Residues | 18 |
Details | BINDING SITE FOR RESIDUE 2DN A 403 |
Chain | Residue |
A | THR39 |
A | MET40 |
A | HIS44 |
A | GLY46 |
A | HIS47 |
A | LYS160 |
A | GLN164 |
A | PRO185 |
A | VAL187 |
A | MET195 |
A | SER196 |
A | SER197 |
A | EDO405 |
A | HOH515 |
A | HOH679 |
A | HOH684 |
A | HOH693 |
A | PRO38 |
site_id | AC4 |
Number of Residues | 8 |
Details | BINDING SITE FOR RESIDUE EDO A 404 |
Chain | Residue |
A | MET109 |
A | TYR110 |
A | GLY113 |
A | LEU114 |
A | ARG115 |
A | THR116 |
A | LYS145 |
B | ASP174 |
site_id | AC5 |
Number of Residues | 5 |
Details | BINDING SITE FOR RESIDUE EDO A 405 |
Chain | Residue |
A | GLN72 |
A | VAL142 |
A | 2DN403 |
A | HOH580 |
A | HOH684 |
site_id | AC6 |
Number of Residues | 6 |
Details | BINDING SITE FOR RESIDUE EDO A 406 |
Chain | Residue |
A | ALA53 |
A | VAL57 |
A | ARG154 |
A | PHE156 |
A | VAL182 |
A | HOH655 |
site_id | AC7 |
Number of Residues | 1 |
Details | BINDING SITE FOR RESIDUE EOH A 407 |
Chain | Residue |
A | MET71 |
site_id | AC8 |
Number of Residues | 7 |
Details | BINDING SITE FOR RESIDUE EDO A 408 |
Chain | Residue |
A | LEU147 |
A | GLN148 |
A | ASP178 |
A | HOH536 |
A | HOH689 |
B | GLN148 |
B | ARG151 |
site_id | AC9 |
Number of Residues | 19 |
Details | BINDING SITE FOR RESIDUE 2DN B 401 |
Chain | Residue |
B | THR39 |
B | MET40 |
B | HIS44 |
B | GLY46 |
B | HIS47 |
B | HIS135 |
B | GLN164 |
B | PRO185 |
B | VAL187 |
B | MET195 |
B | SER196 |
B | SER197 |
B | EDO404 |
B | HOH541 |
B | HOH654 |
B | HOH657 |
B | HOH661 |
B | HOH662 |
B | HOH671 |
site_id | BC1 |
Number of Residues | 9 |
Details | BINDING SITE FOR RESIDUE EDO B 402 |
Chain | Residue |
A | ASP174 |
B | MET109 |
B | TYR110 |
B | GLY113 |
B | LEU114 |
B | ARG115 |
B | THR116 |
B | LYS145 |
B | HOH523 |
site_id | BC2 |
Number of Residues | 1 |
Details | BINDING SITE FOR RESIDUE EDO B 403 |
Chain | Residue |
B | HOH643 |
site_id | BC3 |
Number of Residues | 3 |
Details | BINDING SITE FOR RESIDUE EDO B 404 |
Chain | Residue |
B | PRO38 |
B | 2DN401 |
B | HOH592 |
site_id | BC4 |
Number of Residues | 4 |
Details | BINDING SITE FOR RESIDUE EDO B 405 |
Chain | Residue |
B | GLY244 |
B | ARG273 |
B | GLY275 |
B | HOH677 |
site_id | BC5 |
Number of Residues | 3 |
Details | BINDING SITE FOR RESIDUE 2DN B 406 |
Chain | Residue |
B | PRO58 |
B | ARG154 |
B | PHE156 |
site_id | BC6 |
Number of Residues | 2 |
Details | BINDING SITE FOR RESIDUE EOH B 407 |
Chain | Residue |
B | ASN176 |
B | HOH531 |
Functional Information from SwissProt/UniProt
site_id | SWS_FT_FI1 |
Number of Residues | 2 |
Details | ACT_SITE: Proton donor |
Chain | Residue | Details |
A | HIS47 | |
B | HIS47 |
site_id | SWS_FT_FI2 |
Number of Residues | 8 |
Details | BINDING: BINDING => ECO:0000269|PubMed:16460002 |
Chain | Residue | Details |
A | MET40 | |
A | GLY158 | |
A | VAL187 | |
A | MET195 | |
B | MET40 | |
B | GLY158 | |
B | VAL187 | |
B | MET195 |
site_id | SWS_FT_FI3 |
Number of Residues | 10 |
Details | BINDING: |
Chain | Residue | Details |
A | GLN72 | |
B | GLN164 | |
A | ASP88 | |
A | ASP89 | |
A | GLN92 | |
A | GLN164 | |
B | GLN72 | |
B | ASP88 | |
B | ASP89 | |
B | GLN92 |
site_id | SWS_FT_FI4 |
Number of Residues | 2 |
Details | MOD_RES: N-acetylthreonine => ECO:0007744|PubMed:21969609 |
Chain | Residue | Details |
A | ALA2 | |
B | ALA2 |
Catalytic Information from CSA
site_id | MCSA1 |
Number of Residues | 10 |
Details | M-CSA 229 |
Chain | Residue | Details |
A | MET40 | electrostatic stabiliser |
A | ARG198 | electrostatic stabiliser, hydrogen bond donor |
A | HIS44 | electrostatic stabiliser, hydrogen bond donor, van der waals interaction |
A | HIS47 | electrostatic stabiliser, hydrogen bond acceptor, hydrogen bond donor, proton acceptor, proton donor, van der waals interaction |
A | ASP88 | metal ligand |
A | ASP89 | metal ligand |
A | GLN92 | metal ligand |
A | LYS160 | electrostatic stabiliser |
A | SER196 | electrostatic stabiliser, hydrogen bond donor |
A | SER197 | electrostatic stabiliser, hydrogen bond donor |
site_id | MCSA2 |
Number of Residues | 10 |
Details | M-CSA 229 |
Chain | Residue | Details |
B | MET40 | electrostatic stabiliser |
B | ARG198 | electrostatic stabiliser, hydrogen bond donor |
B | HIS44 | electrostatic stabiliser, hydrogen bond donor, van der waals interaction |
B | HIS47 | electrostatic stabiliser, hydrogen bond acceptor, hydrogen bond donor, proton acceptor, proton donor, van der waals interaction |
B | ASP88 | metal ligand |
B | ASP89 | metal ligand |
B | GLN92 | metal ligand |
B | LYS160 | electrostatic stabiliser |
B | SER196 | electrostatic stabiliser, hydrogen bond donor |
B | SER197 | electrostatic stabiliser, hydrogen bond donor |