4MU1

The structure of wt A. thaliana IGPD2 in complex with Mn2+, imidazole, and sulfate at 1.5 A resolution

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000105	biological_process	L-histidine biosynthetic process
A	0004424	molecular_function	imidazoleglycerol-phosphate dehydratase activity

Functional Information from PDB Data

site_id	AC1
Number of Residues	6
Details	BINDING SITE FOR RESIDUE MN A 301

Chain	Residue
A	HIS47
A	HIS74
A	HIS169
A	GLU173
A	IMD303
A	HOH404

---

site_id	AC2
Number of Residues	6
Details	BINDING SITE FOR RESIDUE MN A 302

Chain	Residue
A	HIS170
A	IMD303
A	HOH401
A	HIS73
A	GLU77
A	HIS145

---

site_id	AC3
Number of Residues	8
Details	BINDING SITE FOR RESIDUE IMD A 303

Chain	Residue
A	HIS73
A	GLU77
A	LEU107
A	HIS170
A	GLU173
A	MN301
A	MN302
A	HOH401

---

site_id	AC4
Number of Residues	3
Details	BINDING SITE FOR RESIDUE SO4 A 304

Chain	Residue
A	ARG161
A	ARG161
A	ARG161

---

site_id	AC5
Number of Residues	5
Details	BINDING SITE FOR RESIDUE SO4 A 305

Chain	Residue
A	GLN51
A	HIS55
A	ARG99
A	LYS177
A	HOH495

---

site_id	AC6
Number of Residues	7
Details	BINDING SITE FOR RESIDUE EDO A 306

Chain	Residue
A	GLU18
A	ASN23
A	ASN23
A	SER25
A	ARG63
A	HOH528
A	HOH542

---

site_id	AC7
Number of Residues	8
Details	BINDING SITE FOR RESIDUE EDO A 307

Chain	Residue
A	LEU88
A	ARG94
A	LEU118
A	SER119
A	GLY120
A	SER154
A	GLY155
A	HOH503

---

site_id	AC8
Number of Residues	5
Details	BINDING SITE FOR RESIDUE EDO A 308

Chain	Residue
A	GLU93
A	ARG94
A	LYS95
A	HOH444
A	HOH565

---

Functional Information from PROSITE/UniProt

site_id	PS00954
Number of Residues	14
Details	IGP_DEHYDRATASE_1 Imidazoleglycerol-phosphate dehydratase signature 1. IDdHHtnEdvALAI

Chain	Residue	Details
A	ILE70-ILE83

---

site_id	PS00955
Number of Residues	13
Details	IGP_DEHYDRATASE_2 Imidazoleglycerol-phosphate dehydratase signature 2. GkNsHHiiEAtFK

Chain	Residue	Details
A	GLY165-LYS177

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	1
Details	Binding site: {"evidences":[{"source":"PubMed","id":"27717128","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"5EKW","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5EL9","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5ELW","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	8
Details	Binding site: {"evidences":[{"source":"PubMed","id":"26095028","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"27717128","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"4MU3","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4QNK","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5EKW","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5ELW","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	4
Details	Binding site: {"evidences":[{"source":"PubMed","id":"26095028","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"27717128","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"4MU0","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4MU1","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4MU4","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4QNJ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4QNK","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5EKW","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5EL9","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5ELW","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	4
Details	Binding site: {"evidences":[{"source":"PubMed","id":"26095028","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"27717128","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"4MU1","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4MU3","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4MU4","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5EKW","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5EL9","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5ELW","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	4
Details	Binding site: {"evidences":[{"source":"PubMed","id":"26095028","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"27717128","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"4MU0","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4MU3","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4MU4","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4QNJ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4QNK","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5ELW","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI6
Number of Residues	1
Details	Binding site: {"evidences":[{"source":"PubMed","id":"26095028","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"27717128","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"4MU3","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4MU4","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4QNK","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5EKW","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5EL9","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5ELW","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI7
Number of Residues	1
Details	Binding site: {"evidences":[{"source":"PubMed","id":"26095028","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"27717128","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"4MU4","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5EKW","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5EL9","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5ELW","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI8
Number of Residues	8
Details	Binding site: {"evidences":[{"source":"PubMed","id":"26095028","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"27717128","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"4MU1","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4MU3","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4MU4","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4QNK","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5EKW","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5EL9","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---