4MSM

Crystal structure of Schizosaccharomyces pombe AMSH-like protease sst2 E286A mutant bound to ubiquitin

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0008233	molecular_function	peptidase activity
A	0008237	molecular_function	metallopeptidase activity
A	0016579	biological_process	protein deubiquitination
A	0061578	molecular_function	K63-linked deubiquitinase activity
A	0070536	biological_process	protein K63-linked deubiquitination
A	0140492	molecular_function	metal-dependent deubiquitinase activity
C	0008233	molecular_function	peptidase activity
C	0008237	molecular_function	metallopeptidase activity
C	0016579	biological_process	protein deubiquitination
C	0061578	molecular_function	K63-linked deubiquitinase activity
C	0070536	biological_process	protein K63-linked deubiquitination
C	0140492	molecular_function	metal-dependent deubiquitinase activity

Functional Information from PDB Data

site_id	AC1
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN A 501

Chain	Residue
A	HIS341
A	HIS343
A	ASP354
A	HOH694

---

site_id	AC2
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN A 502

Chain	Residue
A	HIS356
A	CYS397
A	HIS404
A	HIS406

---

site_id	AC3
Number of Residues	3
Details	BINDING SITE FOR RESIDUE EDO A 503

Chain	Residue
A	HOH604
B	THR9
A	ARG261

---

site_id	AC4
Number of Residues	8
Details	BINDING SITE FOR RESIDUE EDO A 504

Chain	Residue
A	HIS356
A	CYS359
A	SER360
A	HOH627
A	HOH692
A	HOH718
B	PRO37
B	GLN40

---

site_id	AC5
Number of Residues	4
Details	BINDING SITE FOR RESIDUE PO4 A 505

Chain	Residue
A	LYS409
A	THR412
A	MET413
A	HOH657

---

site_id	AC6
Number of Residues	6
Details	BINDING SITE FOR RESIDUE EDO B 101

Chain	Residue
A	HOH603
B	THR7
B	LEU8
B	LEU69
B	VAL70
B	LEU71

---

site_id	AC7
Number of Residues	5
Details	BINDING SITE FOR RESIDUE EDO B 102

Chain	Residue
B	ARG54
C	LYS409
C	TYR411
C	PO4508
C	HOH612

---

site_id	AC8
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN C 501

Chain	Residue
C	HIS341
C	HIS343
C	ASP354
D	HOH240

---

site_id	AC9
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN C 502

Chain	Residue
C	HIS356
C	CYS397
C	HIS404
C	HIS406

---

site_id	BC1
Number of Residues	4
Details	BINDING SITE FOR RESIDUE EDO C 503

Chain	Residue
C	LEU274
C	PRO375
C	HOH672
C	HOH702

---

site_id	BC2
Number of Residues	2
Details	BINDING SITE FOR RESIDUE EDO C 504

Chain	Residue
C	LYS294
C	PO4508

---

site_id	BC3
Number of Residues	8
Details	BINDING SITE FOR RESIDUE EDO C 505

Chain	Residue
C	LYS258
C	GLN362
C	LEU363
C	PRO366
C	ASP387
C	HOH693
C	HOH713
C	HOH715

---

site_id	BC4
Number of Residues	6
Details	BINDING SITE FOR RESIDUE EDO C 506

Chain	Residue
C	HIS356
C	CYS397
C	ARG398
C	LYS399
C	HIS404
C	HOH709

---

site_id	BC5
Number of Residues	6
Details	BINDING SITE FOR RESIDUE EDO C 507

Chain	Residue
C	GLU311
C	GLY318
C	THR319
C	THR320
C	HOH699
D	ARG74

---

site_id	BC6
Number of Residues	6
Details	BINDING SITE FOR RESIDUE PO4 C 508

Chain	Residue
B	EDO102
C	LYS409
C	THR412
C	MET413
C	EDO504
C	HOH626

---

site_id	BC7
Number of Residues	6
Details	BINDING SITE FOR RESIDUE EDO D 101

Chain	Residue
C	HOH604
D	THR7
D	LEU8
D	LEU69
D	VAL70
D	LEU71

---

Functional Information from PROSITE/UniProt

site_id	PS00299
Number of Residues	26
Details	UBIQUITIN_1 Ubiquitin domain signature. KakIqDkegIPpdqQrLIFaGkqleD

Chain	Residue	Details
B	LYS27-ASP52

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	6
Details	BINDING: BINDING => ECO:0000255|PROSITE-ProRule:PRU01182

Chain	Residue	Details
A	HIS341
A	HIS343
A	ASP354
C	HIS341
C	HIS343
C	ASP354

---

site_id	SWS_FT_FI2
Number of Residues	8
Details	BINDING: BINDING => ECO:0000250

Chain	Residue	Details
A	HIS356
A	CYS397
A	HIS404
A	HIS406
C	HIS356
C	CYS397
C	HIS404
C	HIS406

---

site_id	SWS_FT_FI3
Number of Residues	2
Details	SITE: Indirect zinc-binding => ECO:0000250

Chain	Residue	Details
A	ALA286
C	ALA286

---