4MSH

Crystal Structure of PDE10A2 with fragment ZT0143 ((2S)-4-chloro-2,3-dihydro-1,3-benzothiazol-2-amine)

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004114	molecular_function	3',5'-cyclic-nucleotide phosphodiesterase activity
A	0007165	biological_process	signal transduction
A	0008081	molecular_function	phosphoric diester hydrolase activity
B	0004114	molecular_function	3',5'-cyclic-nucleotide phosphodiesterase activity
B	0007165	biological_process	signal transduction
B	0008081	molecular_function	phosphoric diester hydrolase activity

Functional Information from PDB Data

site_id	AC1
Number of Residues	5
Details	BINDING SITE FOR RESIDUE 2D0 A 900

Chain	Residue
A	VAL678
A	ILE692
A	GLN726
A	PHE729
B	LEU706

---

site_id	AC2
Number of Residues	4
Details	BINDING SITE FOR RESIDUE NI A 901

Chain	Residue
A	HIS529
A	HIS563
A	ASP564
A	ASP674

---

site_id	AC3
Number of Residues	1
Details	BINDING SITE FOR RESIDUE NI A 902

Chain	Residue
A	ASP564

---

site_id	AC4
Number of Residues	4
Details	BINDING SITE FOR RESIDUE NI B 901

Chain	Residue
B	HIS529
B	HIS563
B	ASP564
B	ASP674

---

site_id	AC5
Number of Residues	2
Details	BINDING SITE FOR RESIDUE NI B 902

Chain	Residue
B	ASP564
B	GLU592

---

Functional Information from PROSITE/UniProt

site_id	PS00126
Number of Residues	12
Details	PDEASE_I_1 3'5'-cyclic nucleotide phosphodiesterase domain signature. HDLdHrGfsNsY

Chain	Residue	Details
A	HIS563-TYR574

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	634
Details	Domain: {"description":"PDEase","evidences":[{"source":"PROSITE-ProRule","id":"PRU01192","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	2
Details	Active site: {"description":"Proton donor","evidences":[{"source":"UniProtKB","id":"O76083","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	12
Details	Binding site: {"evidences":[{"source":"PubMed","id":"17389385","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---