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4MR4

Crystal Structure of the first bromodomain of human BRD4 in complex with a quinazolinone ligand (RVX-208)

Functional Information from PDB Data
site_idAC1
Number of Residues6
DetailsBINDING SITE FOR RESIDUE EDO A 201
ChainResidue
AILE100
AILE101
ALYS102
ATHR103
AASN135
AHOH462

site_idAC2
Number of Residues6
DetailsBINDING SITE FOR RESIDUE EDO A 202
ChainResidue
A1K0204
AHOH311
AHOH465
ALYS99
AASP145
AILE146

site_idAC3
Number of Residues4
DetailsBINDING SITE FOR RESIDUE EDO A 203
ChainResidue
ATHR134
AGLN159
ALYS160
AHOH481

site_idAC4
Number of Residues11
DetailsBINDING SITE FOR RESIDUE 1K0 A 204
ChainResidue
APRO82
APHE83
AVAL87
ALEU92
ALYS99
ATYR139
AASN140
AILE146
AEDO202
AHOH303
AHOH396

Functional Information from PROSITE/UniProt
site_idPS00633
Number of Residues60
DetailsBROMODOMAIN_1 Bromodomain signature. AwpFqqpvDavklnlpDYYkiIktpMdmgtIkkrlenny..Ywnaqeciqdfnt.MftNCyiY
ChainResidueDetails
AALA80-TYR139

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues1
DetailsSITE: Acetylated histone binding => ECO:0000269|PubMed:22464331
ChainResidueDetails
AASN140

site_idSWS_FT_FI2
Number of Residues2
DetailsCROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2) => ECO:0007744|PubMed:28112733
ChainResidueDetails
ALYS99

219140

PDB entries from 2024-05-01

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