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4MR3

Crystal Structure of the first bromodomain of human BRD4 in complex with a quinazolinone ligand (RVX-OH)

Functional Information from PDB Data
site_idAC1
Number of Residues6
DetailsBINDING SITE FOR RESIDUE EDO A 201
ChainResidue
AILE100
ALYS102
ATHR103
AASN135
AILE138
AHOH443

site_idAC2
Number of Residues14
DetailsBINDING SITE FOR RESIDUE 1K0 A 202
ChainResidue
AVAL87
ALEU92
ATYR139
AASN140
AILE146
AHOH304
AHOH310
AHOH336
AHOH364
AHOH474
AHOH486
APRO82
APHE83
AGLN85

Functional Information from PROSITE/UniProt
site_idPS00633
Number of Residues60
DetailsBROMODOMAIN_1 Bromodomain signature. AwpFqqpvDavklnlpDYYkiIktpMdmgtIkkrlenny..Ywnaqeciqdfnt.MftNCyiY
ChainResidueDetails
AALA80-TYR139

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues1
DetailsSITE: Acetylated histone binding => ECO:0000269|PubMed:22464331
ChainResidueDetails
AASN140

site_idSWS_FT_FI2
Number of Residues2
DetailsCROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2) => ECO:0007744|PubMed:28112733
ChainResidueDetails
ALYS99

237992

PDB entries from 2025-06-25

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