4MQS
Structure of active human M2 muscarinic acetylcholine receptor bound to the agonist iperoxo
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004930 | molecular_function | G protein-coupled receptor activity |
| A | 0005886 | cellular_component | plasma membrane |
| A | 0007186 | biological_process | G protein-coupled receptor signaling pathway |
| A | 0016020 | cellular_component | membrane |
| A | 0016907 | molecular_function | G protein-coupled acetylcholine receptor activity |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 12 |
| Details | BINDING SITE FOR RESIDUE IXO A 501 |
| Chain | Residue |
| A | ASP103 |
| A | TYR426 |
| A | CYS429 |
| A | TYR430 |
| A | TYR104 |
| A | SER107 |
| A | VAL111 |
| A | TRP155 |
| A | ALA194 |
| A | TRP400 |
| A | TYR403 |
| A | ASN404 |
Functional Information from PROSITE/UniProt
| site_id | PS00237 |
| Number of Residues | 17 |
| Details | G_PROTEIN_RECEP_F1_1 G-protein coupled receptors family 1 signature. ASVmNLLIISFDRYFcV |
| Chain | Residue | Details |
| A | ALA109-VAL125 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 25 |
| Details | Transmembrane: {"description":"Helical; Name=1","evidences":[{"source":"PubMed","id":"36690613","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7T8X","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7T90","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7T94","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7T96","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 33 |
| Details | Topological domain: {"description":"Cytoplasmic","evidences":[{"source":"PubMed","id":"36690613","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7T8X","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7T90","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7T94","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7T96","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 24 |
| Details | Transmembrane: {"description":"Helical; Name=2","evidences":[{"source":"PubMed","id":"36690613","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7T8X","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7T90","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7T94","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7T96","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 31 |
| Details | Topological domain: {"description":"Extracellular","evidences":[{"source":"PubMed","id":"36690613","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7T8X","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7T90","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7T94","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7T96","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 26 |
| Details | Transmembrane: {"description":"Helical; Name=3","evidences":[{"source":"PubMed","id":"36690613","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7T8X","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7T90","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7T94","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7T96","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI6 |
| Number of Residues | 21 |
| Details | Transmembrane: {"description":"Helical; Name=4","evidences":[{"source":"PubMed","id":"36690613","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7T8X","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7T90","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7T94","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7T96","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI7 |
| Number of Residues | 24 |
| Details | Transmembrane: {"description":"Helical; Name=5","evidences":[{"source":"PubMed","id":"36690613","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7T8X","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7T90","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7T94","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7T96","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI8 |
| Number of Residues | 24 |
| Details | Transmembrane: {"description":"Helical; Name=6","evidences":[{"source":"PubMed","id":"36690613","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7T8X","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7T90","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7T94","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7T96","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI9 |
| Number of Residues | 22 |
| Details | Transmembrane: {"description":"Helical; Name=7","evidences":[{"source":"PubMed","id":"36690613","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7T8X","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7T90","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7T94","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7T96","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI10 |
| Number of Residues | 2 |
| Details | Modified residue: {"description":"Phosphothreonine","evidences":[{"evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
