Functional Information from GO Data
Chain | GOid | namespace | contents |
A | 0004672 | molecular_function | protein kinase activity |
A | 0004712 | molecular_function | protein serine/threonine/tyrosine kinase activity |
A | 0005524 | molecular_function | ATP binding |
A | 0006468 | biological_process | protein phosphorylation |
A | 0046777 | biological_process | protein autophosphorylation |
B | 0004672 | molecular_function | protein kinase activity |
B | 0004712 | molecular_function | protein serine/threonine/tyrosine kinase activity |
B | 0005524 | molecular_function | ATP binding |
B | 0006468 | biological_process | protein phosphorylation |
B | 0046777 | biological_process | protein autophosphorylation |
C | 0004672 | molecular_function | protein kinase activity |
C | 0004712 | molecular_function | protein serine/threonine/tyrosine kinase activity |
C | 0005524 | molecular_function | ATP binding |
C | 0006468 | biological_process | protein phosphorylation |
C | 0046777 | biological_process | protein autophosphorylation |
D | 0004672 | molecular_function | protein kinase activity |
D | 0004712 | molecular_function | protein serine/threonine/tyrosine kinase activity |
D | 0005524 | molecular_function | ATP binding |
D | 0006468 | biological_process | protein phosphorylation |
D | 0046777 | biological_process | protein autophosphorylation |
Functional Information from PDB Data
site_id | AC1 |
Number of Residues | 19 |
Details | BINDING SITE FOR RESIDUE 2C3 A 501 |
Chain | Residue |
A | ILE165 |
A | GLU239 |
A | MET240 |
A | LEU241 |
A | SER242 |
A | ASN292 |
A | LEU294 |
A | VAL306 |
A | ASP307 |
A | SO4505 |
A | HOH676 |
A | GLY166 |
A | LYS167 |
A | GLY168 |
A | PHE170 |
A | GLY171 |
A | VAL173 |
A | LYS188 |
A | PHE238 |
site_id | AC2 |
Number of Residues | 3 |
Details | BINDING SITE FOR RESIDUE 1PE A 502 |
Chain | Residue |
A | ASP162 |
A | LYS175 |
A | TRP184 |
site_id | AC3 |
Number of Residues | 3 |
Details | BINDING SITE FOR RESIDUE 1PE A 503 |
Chain | Residue |
A | GLN201 |
C | GLN201 |
C | LEU234 |
site_id | AC4 |
Number of Residues | 5 |
Details | BINDING SITE FOR RESIDUE SO4 A 504 |
Chain | Residue |
A | THR466 |
A | ARG467 |
A | ILE468 |
A | GLN469 |
A | TYR472 |
site_id | AC5 |
Number of Residues | 7 |
Details | BINDING SITE FOR RESIDUE SO4 A 505 |
Chain | Residue |
A | GLY168 |
A | SER169 |
A | LYS289 |
A | GLY411 |
A | 2C3501 |
A | HOH758 |
A | HOH782 |
site_id | AC6 |
Number of Residues | 20 |
Details | BINDING SITE FOR RESIDUE 2C3 B 501 |
Chain | Residue |
B | ILE165 |
B | LYS167 |
B | GLY168 |
B | GLY171 |
B | GLN172 |
B | LYS188 |
B | PHE238 |
B | GLU239 |
B | MET240 |
B | LEU241 |
B | SER242 |
B | TYR243 |
B | ASN292 |
B | LEU294 |
B | VAL306 |
B | ASP307 |
B | 1PE502 |
B | HOH637 |
B | HOH700 |
D | GLN182 |
site_id | AC7 |
Number of Residues | 4 |
Details | BINDING SITE FOR RESIDUE 1PE B 502 |
Chain | Residue |
B | ASP162 |
B | LYS175 |
B | TRP184 |
B | 2C3501 |
site_id | AC8 |
Number of Residues | 3 |
Details | BINDING SITE FOR RESIDUE 1PE B 503 |
Chain | Residue |
B | GLN201 |
B | MET229 |
D | GLN201 |
site_id | AC9 |
Number of Residues | 3 |
Details | BINDING SITE FOR RESIDUE SO4 B 504 |
Chain | Residue |
B | LYS264 |
B | ARG300 |
B | SER301 |
site_id | BC1 |
Number of Residues | 4 |
Details | BINDING SITE FOR RESIDUE SO4 B 505 |
Chain | Residue |
B | ARG467 |
B | ILE468 |
B | GLN469 |
B | TYR472 |
site_id | BC2 |
Number of Residues | 18 |
Details | BINDING SITE FOR RESIDUE 2C3 C 501 |
Chain | Residue |
C | ILE165 |
C | LYS167 |
C | GLY168 |
C | GLY171 |
C | VAL173 |
C | LYS188 |
C | PHE238 |
C | GLU239 |
C | MET240 |
C | LEU241 |
C | SER242 |
C | TYR243 |
C | ASN292 |
C | LEU294 |
C | VAL306 |
C | ASP307 |
C | 1PE502 |
C | SO4503 |
site_id | BC3 |
Number of Residues | 5 |
Details | BINDING SITE FOR RESIDUE 1PE C 502 |
Chain | Residue |
C | ASP162 |
C | LYS175 |
C | TRP184 |
C | 2C3501 |
C | HOH615 |
site_id | BC4 |
Number of Residues | 4 |
Details | BINDING SITE FOR RESIDUE SO4 C 503 |
Chain | Residue |
C | GLY168 |
C | SER169 |
C | 2C3501 |
C | HOH619 |
site_id | BC5 |
Number of Residues | 4 |
Details | BINDING SITE FOR RESIDUE SO4 C 504 |
Chain | Residue |
C | ASN365 |
C | GLU366 |
C | LYS393 |
C | PTR321 |
site_id | BC6 |
Number of Residues | 17 |
Details | BINDING SITE FOR RESIDUE 2C3 D 501 |
Chain | Residue |
D | ILE165 |
D | LYS167 |
D | GLY168 |
D | PHE170 |
D | GLY171 |
D | VAL173 |
D | LYS188 |
D | PHE238 |
D | GLU239 |
D | MET240 |
D | LEU241 |
D | SER242 |
D | ASN292 |
D | LEU294 |
D | ASP307 |
D | 1PE502 |
D | SO4503 |
site_id | BC7 |
Number of Residues | 6 |
Details | BINDING SITE FOR RESIDUE 1PE D 502 |
Chain | Residue |
D | ASP162 |
D | LYS175 |
D | TRP184 |
D | 2C3501 |
D | HOH650 |
D | HOH651 |
site_id | BC8 |
Number of Residues | 4 |
Details | BINDING SITE FOR RESIDUE SO4 D 503 |
Chain | Residue |
D | GLY168 |
D | SER169 |
D | LYS289 |
D | 2C3501 |
site_id | BC9 |
Number of Residues | 3 |
Details | BINDING SITE FOR RESIDUE SO4 D 504 |
Chain | Residue |
D | PTR321 |
D | GLU366 |
D | LYS393 |
Functional Information from PROSITE/UniProt
site_id | PS00107 |
Number of Residues | 24 |
Details | PROTEIN_KINASE_ATP Protein kinases ATP-binding region signature. IGKGSFGQVVkAydrveqew..........VAIK |
Chain | Residue | Details |
A | ILE165-LYS188 | |
site_id | PS00108 |
Number of Residues | 13 |
Details | PROTEIN_KINASE_ST Serine/Threonine protein kinases active-site signature. IiHcDLKpeNILL |
Chain | Residue | Details |
A | ILE283-LEU295 | |
Functional Information from SwissProt/UniProt
Chain | Residue | Details |
A | ASP287 | |
B | ASP287 | |
C | ASP287 | |
D | ASP287 | |
site_id | SWS_FT_FI2 |
Number of Residues | 12 |
Details | BINDING: BINDING => ECO:0000305 |
Chain | Residue | Details |
A | ILE165 | |
D | ILE165 | |
D | LYS188 | |
D | PHE238 | |
A | LYS188 | |
A | PHE238 | |
B | ILE165 | |
B | LYS188 | |
B | PHE238 | |
C | ILE165 | |
C | LYS188 | |
C | PHE238 | |
Chain | Residue | Details |
A | TYR140 | |
B | TYR319 | |
B | PTR321 | |
B | TYR449 | |
C | TYR140 | |
C | TYR159 | |
C | TYR177 | |
C | TYR319 | |
C | PTR321 | |
C | TYR449 | |
D | TYR140 | |
A | TYR159 | |
D | TYR159 | |
D | TYR177 | |
D | TYR319 | |
D | PTR321 | |
D | TYR449 | |
A | TYR177 | |
A | TYR319 | |
A | PTR321 | |
A | TYR449 | |
B | TYR140 | |
B | TYR159 | |
B | TYR177 | |
Chain | Residue | Details |
A | TYR145 | |
B | TYR145 | |
C | TYR145 | |
D | TYR145 | |
Chain | Residue | Details |
A | TYR219 | |
B | TYR219 | |
C | TYR219 | |
D | TYR219 | |
Chain | Residue | Details |
A | SER310 | |
B | SER310 | |
C | SER310 | |
D | SER310 | |
Chain | Residue | Details |
A | THR402 | |
B | THR402 | |
C | THR402 | |
D | THR402 | |