Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

4MM1

GGGPS from Methanothermobacter thermautotrophicus

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000107	molecular_function	imidazoleglycerol-phosphate synthase activity
A	0000287	molecular_function	magnesium ion binding
A	0005737	cellular_component	cytoplasm
A	0006650	biological_process	glycerophospholipid metabolic process
A	0008654	biological_process	phospholipid biosynthetic process
A	0016740	molecular_function	transferase activity
A	0016765	molecular_function	transferase activity, transferring alkyl or aryl (other than methyl) groups
A	0046474	biological_process	glycerophospholipid biosynthetic process
A	0046872	molecular_function	metal ion binding
A	0047294	molecular_function	phosphoglycerol geranylgeranyltransferase activity
B	0000107	molecular_function	imidazoleglycerol-phosphate synthase activity
B	0000287	molecular_function	magnesium ion binding
B	0005737	cellular_component	cytoplasm
B	0006650	biological_process	glycerophospholipid metabolic process
B	0008654	biological_process	phospholipid biosynthetic process
B	0016740	molecular_function	transferase activity
B	0016765	molecular_function	transferase activity, transferring alkyl or aryl (other than methyl) groups
B	0046474	biological_process	glycerophospholipid biosynthetic process
B	0046872	molecular_function	metal ion binding
B	0047294	molecular_function	phosphoglycerol geranylgeranyltransferase activity
C	0000107	molecular_function	imidazoleglycerol-phosphate synthase activity
C	0000287	molecular_function	magnesium ion binding
C	0005737	cellular_component	cytoplasm
C	0006650	biological_process	glycerophospholipid metabolic process
C	0008654	biological_process	phospholipid biosynthetic process
C	0016740	molecular_function	transferase activity
C	0016765	molecular_function	transferase activity, transferring alkyl or aryl (other than methyl) groups
C	0046474	biological_process	glycerophospholipid biosynthetic process
C	0046872	molecular_function	metal ion binding
C	0047294	molecular_function	phosphoglycerol geranylgeranyltransferase activity
D	0000107	molecular_function	imidazoleglycerol-phosphate synthase activity
D	0000287	molecular_function	magnesium ion binding
D	0005737	cellular_component	cytoplasm
D	0006650	biological_process	glycerophospholipid metabolic process
D	0008654	biological_process	phospholipid biosynthetic process
D	0016740	molecular_function	transferase activity
D	0016765	molecular_function	transferase activity, transferring alkyl or aryl (other than methyl) groups
D	0046474	biological_process	glycerophospholipid biosynthetic process
D	0046872	molecular_function	metal ion binding
D	0047294	molecular_function	phosphoglycerol geranylgeranyltransferase activity
E	0000107	molecular_function	imidazoleglycerol-phosphate synthase activity
E	0000287	molecular_function	magnesium ion binding
E	0005737	cellular_component	cytoplasm
E	0006650	biological_process	glycerophospholipid metabolic process
E	0008654	biological_process	phospholipid biosynthetic process
E	0016740	molecular_function	transferase activity
E	0016765	molecular_function	transferase activity, transferring alkyl or aryl (other than methyl) groups
E	0046474	biological_process	glycerophospholipid biosynthetic process
E	0046872	molecular_function	metal ion binding
E	0047294	molecular_function	phosphoglycerol geranylgeranyltransferase activity
F	0000107	molecular_function	imidazoleglycerol-phosphate synthase activity
F	0000287	molecular_function	magnesium ion binding
F	0005737	cellular_component	cytoplasm
F	0006650	biological_process	glycerophospholipid metabolic process
F	0008654	biological_process	phospholipid biosynthetic process
F	0016740	molecular_function	transferase activity
F	0016765	molecular_function	transferase activity, transferring alkyl or aryl (other than methyl) groups
F	0046474	biological_process	glycerophospholipid biosynthetic process
F	0046872	molecular_function	metal ion binding
F	0047294	molecular_function	phosphoglycerol geranylgeranyltransferase activity

Functional Information from PDB Data

site_id	AC1
Number of Residues	11
Details	BINDING SITE FOR RESIDUE 1GP A 301

Chain	Residue
A	LEU23
A	THR226
A	HOH414
A	TYR172
A	GLU174
A	SER177
A	GLY178
A	GLY202
A	GLY203
A	GLY204
A	GLY225

site_id	AC2
Number of Residues	3
Details	BINDING SITE FOR RESIDUE PGE A 302

Chain	Residue
A	PRO80
A	PHE95
A	TRP106

site_id	AC3
Number of Residues	9
Details	BINDING SITE FOR RESIDUE 1GP B 301

Chain	Residue
B	LEU23
B	TYR172
B	GLU174
B	SER177
B	GLY178
B	GLY202
B	GLY203
B	GLY204
B	GLY225

site_id	AC4
Number of Residues	4
Details	BINDING SITE FOR RESIDUE PGE B 302

Chain	Residue
B	VAL86
B	TRP106
B	GLN111
B	GLY114

site_id	AC5
Number of Residues	10
Details	BINDING SITE FOR RESIDUE 1GP C 301

Chain	Residue
C	LEU23
C	TYR172
C	GLU174
C	SER177
C	GLY178
C	GLY202
C	GLY203
C	GLY204
C	GLY225
C	THR226

site_id	AC6
Number of Residues	4
Details	BINDING SITE FOR RESIDUE PGE C 302

Chain	Residue
C	PRO80
C	GLY81
C	LEU98
C	GLN111

site_id	AC7
Number of Residues	11
Details	BINDING SITE FOR RESIDUE 1GP D 301

Chain	Residue
D	LEU23
D	PHE79
D	TYR172
D	GLU174
D	SER177
D	GLY178
D	GLY202
D	GLY203
D	GLY204
D	THR224
D	GLY225

site_id	AC8
Number of Residues	3
Details	BINDING SITE FOR RESIDUE PGE D 302

Chain	Residue
D	PRO80
D	LEU98
D	GLN111

site_id	AC9
Number of Residues	10
Details	BINDING SITE FOR RESIDUE 1GP E 301

Chain	Residue
E	LEU23
E	PHE79
E	TYR172
E	GLU174
E	SER177
E	GLY178
E	GLY202
E	GLY203
E	GLY204
E	GLY225

site_id	BC1
Number of Residues	3
Details	BINDING SITE FOR RESIDUE PGE E 302

Chain	Residue
E	VAL86
E	PHE95
E	ALA110

site_id	BC2
Number of Residues	9
Details	BINDING SITE FOR RESIDUE 1GP F 301

Chain	Residue
F	LEU23
F	TYR172
F	GLU174
F	SER177
F	GLY178
F	GLY202
F	GLY203
F	GLY204
F	THR224

site_id	BC3
Number of Residues	7
Details	BINDING SITE FOR RESIDUE PGE F 302

Chain	Residue
F	PRO80
F	GLY81
F	ASN82
F	VAL86
F	TRP106
F	GLN111
F	GLY114

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	12
Details	BINDING: BINDING => ECO:0000255\|HAMAP-Rule:MF_00112

Chain	Residue	Details
A	ASP25
E	SER54
F	ASP25
F	SER54
A	SER54
B	ASP25
B	SER54
C	ASP25
C	SER54
D	ASP25
D	SER54
E	ASP25

site_id	SWS_FT_FI2
Number of Residues	18
Details	BINDING: BINDING => ECO:0000255\|HAMAP-Rule:MF_00112, ECO:0000269\|PubMed:24684232, ECO:0007744\|PDB:4MM1

Chain	Residue	Details
A	TYR172
D	TYR172
D	GLY203
D	GLY225
E	TYR172
E	GLY203
E	GLY225
F	TYR172
F	GLY203
F	GLY225
A	GLY203
A	GLY225
B	TYR172
B	GLY203
B	GLY225
C	TYR172
C	GLY203
C	GLY225

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)