4MLP
Mammalian cryptochrome in complex with a small molecule competitor of its ubiquitin ligase
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 12 |
| Details | BINDING SITE FOR RESIDUE 2CX C 900 |
| Chain | Residue |
| C | GLN307 |
| C | TRP417 |
| C | HOH1343 |
| C | HOH1397 |
| C | TRP310 |
| C | HIS373 |
| C | ARG376 |
| C | HIS377 |
| C | PHE399 |
| C | VAL410 |
| C | SER414 |
| C | TRP415 |
| site_id | AC2 |
| Number of Residues | 12 |
| Details | BINDING SITE FOR RESIDUE 2CX A 900 |
| Chain | Residue |
| A | GLN307 |
| A | TRP310 |
| A | HIS373 |
| A | ARG376 |
| A | HIS377 |
| A | PHE399 |
| A | VAL410 |
| A | SER414 |
| A | TRP415 |
| A | TRP417 |
| A | HOH1343 |
| A | HOH1399 |
| site_id | AC3 |
| Number of Residues | 10 |
| Details | BINDING SITE FOR RESIDUE 2CX B 900 |
| Chain | Residue |
| B | GLN307 |
| B | TRP310 |
| B | HIS373 |
| B | ARG376 |
| B | HIS377 |
| B | PHE399 |
| B | VAL410 |
| B | SER414 |
| B | TRP415 |
| B | TRP417 |
| site_id | AC4 |
| Number of Residues | 11 |
| Details | BINDING SITE FOR RESIDUE 2CX D 900 |
| Chain | Residue |
| D | GLN307 |
| D | TRP310 |
| D | HIS373 |
| D | ARG376 |
| D | HIS377 |
| D | PHE399 |
| D | VAL410 |
| D | SER414 |
| D | TRP415 |
| D | TRP417 |
| D | HOH1299 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 12 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:23503662 |
| Chain | Residue | Details |
| A | HIS373 | |
| A | ASP405 | |
| B | SER270 | |
| B | HIS373 | |
| B | ASP405 | |
| D | SER270 | |
| D | HIS373 | |
| D | ASP405 | |
| C | SER270 | |
| C | HIS373 | |
| C | ASP405 | |
| A | SER270 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 4 |
| Details | BINDING: BINDING => ECO:0000250|UniProtKB:P97784 |
| Chain | Residue | Details |
| C | GLN307 | |
| A | GLN307 | |
| B | GLN307 | |
| D | GLN307 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 8 |
| Details | MOD_RES: Phosphoserine => ECO:0000250|UniProtKB:P97784 |
| Chain | Residue | Details |
| B | SER89 | |
| B | SER298 | |
| D | SER89 | |
| D | SER298 | |
| C | SER89 | |
| C | SER298 | |
| A | SER89 | |
| A | SER298 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 4 |
| Details | MOD_RES: Phosphoserine; by MAPK => ECO:0000269|PubMed:11875063, ECO:0000269|PubMed:15298678 |
| Chain | Residue | Details |
| C | SER265 | |
| A | SER265 | |
| B | SER265 | |
| D | SER265 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 4 |
| Details | CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000250|UniProtKB:P97784 |
| Chain | Residue | Details |
| C | LYS29 | |
| A | LYS29 | |
| B | LYS29 | |
| D | LYS29 |
| site_id | SWS_FT_FI6 |
| Number of Residues | 24 |
| Details | CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000269|PubMed:23452856 |
| Chain | Residue | Details |
| C | LYS474 | |
| C | LYS503 | |
| A | LYS125 | |
| A | LYS241 | |
| A | LYS347 | |
| A | LYS474 | |
| A | LYS503 | |
| B | LYS125 | |
| B | LYS241 | |
| B | LYS347 | |
| B | LYS474 | |
| B | LYS503 | |
| D | LYS125 | |
| D | LYS241 | |
| D | LYS347 | |
| D | LYS474 | |
| D | LYS503 | |
| C | LYS125 | |
| C | LYS241 | |
| C | LYS347 |
