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4MK8

Hepatitis C Virus polymerase NS5B genotype 1b (BK) in complex with inhibitor 4 (N-(4-{2-[3-tert-butyl-2-methoxy-5-(2-oxo-1,2-dihydropyridin-3-yl)phenyl]ethyl}phenyl)methanesulfonamide)

Functional Information from GO Data
ChainGOidnamespacecontents
A0003723molecular_functionRNA binding
A0003968molecular_functionRNA-dependent RNA polymerase activity
A0039694biological_processviral RNA genome replication
B0003723molecular_functionRNA binding
B0003968molecular_functionRNA-dependent RNA polymerase activity
B0039694biological_processviral RNA genome replication
Functional Information from PDB Data
site_idAC1
Number of Residues7
DetailsBINDING SITE FOR RESIDUE DMS A 601
ChainResidue
AARG200
ALEU204
AVAL321
AILE363
ASER365
ASER368
ALEU384

site_idAC2
Number of Residues14
DetailsBINDING SITE FOR RESIDUE 28Q A 602
ChainResidue
AASN316
AGLY317
AASP318
AASP319
ASER368
AGLY410
AASN411
AMET414
AGLN446
AILE447
ATYR448
ASER556
ASER288
AASN291

site_idAC3
Number of Residues6
DetailsBINDING SITE FOR RESIDUE DMS B 601
ChainResidue
BARG200
BLEU204
BVAL321
BILE363
BSER365
BSER368

site_idAC4
Number of Residues3
DetailsBINDING SITE FOR RESIDUE DMS B 602
ChainResidue
AARG401
AHIS402
BGLN184

site_idAC5
Number of Residues4
DetailsBINDING SITE FOR RESIDUE GOL B 603
ChainResidue
BGLU143
BVAL144
BARG394
BGLU398

site_idAC6
Number of Residues17
DetailsBINDING SITE FOR RESIDUE 28Q B 604
ChainResidue
BPHE193
BARG200
BSER288
BASN291
BASN316
BGLY317
BASP318
BASP319
BSER368
BGLY410
BASN411
BMET414
BTYR415
BGLN446
BILE447
BTYR448
BSER556

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues6
DetailsBINDING: BINDING => ECO:0000305|PubMed:10557268, ECO:0000305|PubMed:11884572
ChainResidueDetails
AASP220
AASP318
AASP319
BASP220
BASP318
BASP319

site_idSWS_FT_FI2
Number of Residues4
DetailsMOD_RES: Phosphoserine; by host => ECO:0000250|UniProtKB:P26662
ChainResidueDetails
ASER29
ASER42
BSER29
BSER42

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PDB entries from 2024-06-12

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