4MJQ

E. coli sliding clamp in complex with Bromfenac

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003677	molecular_function	DNA binding
A	0003887	molecular_function	DNA-directed DNA polymerase activity
A	0005515	molecular_function	protein binding
A	0005737	cellular_component	cytoplasm
A	0005829	cellular_component	cytosol
A	0006260	biological_process	DNA replication
A	0006261	biological_process	DNA-templated DNA replication
A	0006271	biological_process	DNA strand elongation involved in DNA replication
A	0006974	biological_process	DNA damage response
A	0008408	molecular_function	3'-5' exonuclease activity
A	0009360	cellular_component	DNA polymerase III complex
A	0016740	molecular_function	transferase activity
A	0016779	molecular_function	nucleotidyltransferase activity
A	0030174	biological_process	regulation of DNA-templated DNA replication initiation
A	0030894	cellular_component	replisome
A	0032297	biological_process	negative regulation of DNA-templated DNA replication initiation
A	0042276	biological_process	error-prone translesion synthesis
A	0042802	molecular_function	identical protein binding
A	0042803	molecular_function	protein homodimerization activity
A	0044787	biological_process	bacterial-type DNA replication
A	1990078	cellular_component	replication inhibiting complex
A	1990085	cellular_component	Hda-beta clamp complex
B	0003677	molecular_function	DNA binding
B	0003887	molecular_function	DNA-directed DNA polymerase activity
B	0005515	molecular_function	protein binding
B	0005737	cellular_component	cytoplasm
B	0005829	cellular_component	cytosol
B	0006260	biological_process	DNA replication
B	0006261	biological_process	DNA-templated DNA replication
B	0006271	biological_process	DNA strand elongation involved in DNA replication
B	0006974	biological_process	DNA damage response
B	0008408	molecular_function	3'-5' exonuclease activity
B	0009360	cellular_component	DNA polymerase III complex
B	0016740	molecular_function	transferase activity
B	0016779	molecular_function	nucleotidyltransferase activity
B	0030174	biological_process	regulation of DNA-templated DNA replication initiation
B	0030894	cellular_component	replisome
B	0032297	biological_process	negative regulation of DNA-templated DNA replication initiation
B	0042276	biological_process	error-prone translesion synthesis
B	0042802	molecular_function	identical protein binding
B	0042803	molecular_function	protein homodimerization activity
B	0044787	biological_process	bacterial-type DNA replication
B	1990078	cellular_component	replication inhibiting complex
B	1990085	cellular_component	Hda-beta clamp complex

Functional Information from PDB Data

site_id	AC1
Number of Residues	8
Details	BINDING SITE FOR RESIDUE 27R A 401

Chain	Residue
A	ARG152
A	TYR154
A	THR172
A	HIS175
A	VAL247
A	HOH585
A	HOH803
B	GLU84

---

site_id	AC2
Number of Residues	4
Details	BINDING SITE FOR RESIDUE PGE A 402

Chain	Residue
A	TRP122
A	ARG224
B	ALA38
A	ASP121

---

site_id	AC3
Number of Residues	2
Details	BINDING SITE FOR RESIDUE CA A 403

Chain	Residue
A	SER181
A	SER356

---

site_id	AC4
Number of Residues	2
Details	BINDING SITE FOR RESIDUE CA A 404

Chain	Residue
A	GLY46
A	GLU202

---

site_id	AC5
Number of Residues	1
Details	BINDING SITE FOR RESIDUE CL A 405

Chain	Residue
A	ARG105

---

site_id	AC6
Number of Residues	3
Details	BINDING SITE FOR RESIDUE EDO A 406

Chain	Residue
A	ARG105
A	TYR284
A	GLN289

---

site_id	AC7
Number of Residues	7
Details	BINDING SITE FOR RESIDUE PGE B 401

Chain	Residue
A	ARG152
A	GLN265
B	ARG7
B	ARG80
B	LEU82
B	HOH705
B	HOH818

---

site_id	AC8
Number of Residues	2
Details	BINDING SITE FOR RESIDUE CA B 402

Chain	Residue
B	SER181
B	SER356

---

site_id	AC9
Number of Residues	13
Details	BINDING SITE FOR RESIDUE PG4 B 403

Chain	Residue
A	GLU301
A	GLU303
A	HOH690
B	ARG96
B	ARG105
B	SER107
B	TYR284
B	SER286
B	GLN289
B	HOH631
B	HOH660
B	HOH687
B	HOH777

---

site_id	BC1
Number of Residues	2
Details	BINDING SITE FOR RESIDUE CL B 404

Chain	Residue
B	HIS175
B	ARG176

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	228
Details	Region: {"description":"2","evidences":[{"evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	240
Details	Region: {"description":"3","evidences":[{"evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	6
Details	Binding site: {"evidences":[{"source":"PubMed","id":"18191219","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	2
Details	Binding site: {"evidences":[{"source":"PubMed","id":"18191219","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---