4MIO
Crystal Structure of myo-inositol dehydrogenase from Lactobacillus casei in complex with NAD(H) and myo-inositol
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0000166 | molecular_function | nucleotide binding |
| A | 0016491 | molecular_function | oxidoreductase activity |
| A | 0019310 | biological_process | inositol catabolic process |
| A | 0050112 | molecular_function | inositol 2-dehydrogenase (NAD+) activity |
| B | 0000166 | molecular_function | nucleotide binding |
| B | 0016491 | molecular_function | oxidoreductase activity |
| B | 0019310 | biological_process | inositol catabolic process |
| B | 0050112 | molecular_function | inositol 2-dehydrogenase (NAD+) activity |
| C | 0000166 | molecular_function | nucleotide binding |
| C | 0016491 | molecular_function | oxidoreductase activity |
| C | 0019310 | biological_process | inositol catabolic process |
| C | 0050112 | molecular_function | inositol 2-dehydrogenase (NAD+) activity |
| D | 0000166 | molecular_function | nucleotide binding |
| D | 0016491 | molecular_function | oxidoreductase activity |
| D | 0019310 | biological_process | inositol catabolic process |
| D | 0050112 | molecular_function | inositol 2-dehydrogenase (NAD+) activity |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 21 |
| Details | BINDING SITE FOR RESIDUE NAI A 401 |
| Chain | Residue |
| A | GLY11 |
| A | HIS79 |
| A | GLU96 |
| A | LYS97 |
| A | GLY124 |
| A | HIS176 |
| A | TRP274 |
| A | TYR282 |
| A | HOH558 |
| A | HOH632 |
| A | HOH649 |
| A | ALA12 |
| A | HOH714 |
| A | HOH738 |
| A | MET13 |
| A | ASP35 |
| A | ILE36 |
| A | VAL73 |
| A | SER74 |
| A | PHE75 |
| A | ALA78 |
| site_id | AC2 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE GOL A 402 |
| Chain | Residue |
| A | ARG152 |
| A | ALA153 |
| A | SER154 |
| A | GLU241 |
| A | HOH612 |
| C | ARG152 |
| C | GLU241 |
| site_id | AC3 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE GOL A 403 |
| Chain | Residue |
| A | LEU25 |
| A | ASN283 |
| A | THR284 |
| A | HOH516 |
| A | HOH633 |
| A | HOH726 |
| site_id | AC4 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE GOL A 404 |
| Chain | Residue |
| A | LEU140 |
| A | ASP141 |
| A | PRO148 |
| A | LEU185 |
| A | HOH514 |
| C | SO4405 |
| C | HOH613 |
| site_id | AC5 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE SO4 A 405 |
| Chain | Residue |
| A | THR26 |
| A | GLY27 |
| A | HOH604 |
| A | HOH728 |
| A | HOH746 |
| D | THR26 |
| D | GLY27 |
| site_id | AC6 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE SO4 A 406 |
| Chain | Residue |
| A | ARG198 |
| A | HOH577 |
| A | HOH614 |
| A | HOH664 |
| C | ALA147 |
| C | PRO148 |
| C | LYS220 |
| site_id | AC7 |
| Number of Residues | 26 |
| Details | BINDING SITE FOR RESIDUE NAI B 401 |
| Chain | Residue |
| B | GLY11 |
| B | ALA12 |
| B | MET13 |
| B | ASP35 |
| B | ILE36 |
| B | VAL73 |
| B | SER74 |
| B | PHE75 |
| B | GLY76 |
| B | ALA78 |
| B | HIS79 |
| B | GLU96 |
| B | LYS97 |
| B | GLY124 |
| B | MET126 |
| B | HIS176 |
| B | TYR282 |
| B | HOH519 |
| B | HOH619 |
| B | HOH621 |
| B | HOH623 |
| B | HOH629 |
| B | HOH639 |
| B | HOH658 |
| B | HOH681 |
| B | HOH757 |
| site_id | AC8 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE GOL B 402 |
| Chain | Residue |
| A | HOH518 |
| B | LEU140 |
| B | ASP141 |
| B | GLY143 |
| B | PRO148 |
| B | HOH600 |
| site_id | AC9 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE GOL B 403 |
| Chain | Residue |
| A | GLN266 |
| A | GLN267 |
| A | THR268 |
| B | ILE259 |
| B | GLN266 |
| B | THR268 |
| site_id | BC1 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE GOL B 404 |
| Chain | Residue |
| B | HOH658 |
| B | HIS155 |
| B | ASP172 |
| B | THR173 |
| B | HIS176 |
| B | TYR236 |
| B | HOH529 |
| site_id | BC2 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE GOL B 405 |
| Chain | Residue |
| B | ILE275 |
| B | HOH629 |
| B | HOH635 |
| B | HOH662 |
| site_id | BC3 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE GOL B 406 |
| Chain | Residue |
| B | ARG152 |
| B | ALA153 |
| B | SER154 |
| B | GLU241 |
| B | HOH599 |
| D | ARG152 |
| D | GLU241 |
| site_id | BC4 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE SO4 B 407 |
| Chain | Residue |
| B | HOH625 |
| B | HOH769 |
| C | PHE75 |
| C | GLY76 |
| C | GLY77 |
| C | HOH773 |
| C | HOH796 |
| site_id | BC5 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE SO4 B 408 |
| Chain | Residue |
| B | ARG198 |
| B | HOH595 |
| B | HOH760 |
| D | PRO148 |
| D | LYS220 |
| site_id | BC6 |
| Number of Residues | 29 |
| Details | BINDING SITE FOR RESIDUE NAI C 401 |
| Chain | Residue |
| B | HOH743 |
| C | GLY11 |
| C | ALA12 |
| C | MET13 |
| C | ASP35 |
| C | ILE36 |
| C | VAL73 |
| C | SER74 |
| C | PHE75 |
| C | GLY76 |
| C | ALA78 |
| C | HIS79 |
| C | GLU96 |
| C | LYS97 |
| C | GLY124 |
| C | MET126 |
| C | HIS176 |
| C | TYR282 |
| C | HOH508 |
| C | HOH578 |
| C | HOH615 |
| C | HOH632 |
| C | HOH634 |
| C | HOH636 |
| C | HOH709 |
| C | HOH771 |
| C | HOH776 |
| C | HOH777 |
| C | HOH806 |
| site_id | BC7 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE GOL C 402 |
| Chain | Residue |
| C | HOH597 |
| C | HOH600 |
| C | HOH620 |
| C | HOH679 |
| C | HOH759 |
| site_id | BC8 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE GOL C 403 |
| Chain | Residue |
| A | ARG152 |
| A | GLU241 |
| C | ARG152 |
| C | ALA153 |
| C | SER154 |
| C | GLU241 |
| C | HOH688 |
| site_id | BC9 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE GOL C 404 |
| Chain | Residue |
| C | ILE259 |
| C | GLN266 |
| C | THR268 |
| D | ILE259 |
| D | GLN266 |
| D | GLN267 |
| D | THR268 |
| site_id | CC1 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE SO4 C 405 |
| Chain | Residue |
| A | ALA147 |
| A | PRO148 |
| A | LYS220 |
| A | GOL404 |
| C | ARG198 |
| C | HOH613 |
| C | HOH718 |
| site_id | CC2 |
| Number of Residues | 30 |
| Details | BINDING SITE FOR RESIDUE NAI D 401 |
| Chain | Residue |
| C | HOH629 |
| C | HOH699 |
| D | GLY11 |
| D | ALA12 |
| D | MET13 |
| D | ASP35 |
| D | ILE36 |
| D | VAL73 |
| D | SER74 |
| D | PHE75 |
| D | ALA78 |
| D | HIS79 |
| D | GLU96 |
| D | LYS97 |
| D | MET126 |
| D | ASP172 |
| D | TRP274 |
| D | TYR282 |
| D | INS402 |
| D | HOH501 |
| D | HOH538 |
| D | HOH541 |
| D | HOH552 |
| D | HOH590 |
| D | HOH641 |
| D | HOH642 |
| D | HOH681 |
| D | HOH688 |
| D | HOH770 |
| D | HOH779 |
| site_id | CC3 |
| Number of Residues | 11 |
| Details | BINDING SITE FOR RESIDUE INS D 402 |
| Chain | Residue |
| D | LYS97 |
| D | HIS155 |
| D | ASN157 |
| D | ASP172 |
| D | THR173 |
| D | HIS176 |
| D | TYR236 |
| D | NAI401 |
| D | HOH522 |
| D | HOH594 |
| D | HOH641 |
| site_id | CC4 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE GOL D 403 |
| Chain | Residue |
| D | TYR129 |
| D | GLU288 |
| D | SO4407 |
| D | HOH678 |
| D | HOH799 |
| site_id | CC5 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE GOL D 404 |
| Chain | Residue |
| D | GLN280 |
| D | ASN283 |
| D | HOH628 |
| D | HOH744 |
| site_id | CC6 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE GOL D 405 |
| Chain | Residue |
| B | ARG152 |
| B | GLU241 |
| D | ARG152 |
| D | ALA153 |
| D | SER154 |
| D | GLU241 |
| D | HOH561 |
| site_id | CC7 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE GOL D 406 |
| Chain | Residue |
| C | ARG46 |
| D | SER165 |
| D | ASN205 |
| D | GLU206 |
| D | HOH526 |
| D | HOH706 |
| site_id | CC8 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE SO4 D 407 |
| Chain | Residue |
| D | ARG134 |
| D | TRP183 |
| D | GOL403 |
