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4MIA

Hepatitis C Virus polymerase NS5B genotype 1b (BK) in complex with RG7109 (N-{4-[6-tert-butyl-5-methoxy-8-(6-methoxy-2-oxo-2,5-dihydropyridin-3-yl)quinolin-3-yl]phenyl}methanesulfonamide)

Functional Information from GO Data
ChainGOidnamespacecontents
A0003723molecular_functionRNA binding
A0003968molecular_functionRNA-directed RNA polymerase activity
A0039694biological_processviral RNA genome replication
B0003723molecular_functionRNA binding
B0003968molecular_functionRNA-directed RNA polymerase activity
B0039694biological_processviral RNA genome replication
Functional Information from PDB Data
site_idAC1
Number of Residues2
DetailsBINDING SITE FOR RESIDUE ZN A 601
ChainResidue
AASP66
BHIS1

site_idAC2
Number of Residues17
DetailsBINDING SITE FOR RESIDUE 28L A 602
ChainResidue
ASER368
ASER407
AGLY410
AASN411
AMET414
ATYR415
AGLN446
AILE447
ATYR448
ASER556
APHE193
AARG200
AASN291
AASN316
AGLY317
AASP318
ACYS366

site_idAC3
Number of Residues2
DetailsBINDING SITE FOR RESIDUE ZN B 601
ChainResidue
AHIS1
BASP66

site_idAC4
Number of Residues16
DetailsBINDING SITE FOR RESIDUE 28L B 602
ChainResidue
BPHE193
BSER288
BASN291
BASN316
BGLY317
BASP318
BCYS366
BASN411
BMET414
BTYR415
BGLN446
BILE447
BTYR448
BSER556
BHOH735
BHOH796

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues236
DetailsDomain: {"description":"RdRp catalytic","evidences":[{"source":"PROSITE-ProRule","id":"PRU00539","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails

site_idSWS_FT_FI2
Number of Residues6
DetailsBinding site: {"evidences":[{"source":"PubMed","id":"10557268","evidenceCode":"ECO:0000305"},{"source":"PubMed","id":"11884572","evidenceCode":"ECO:0000305"}]}
ChainResidueDetails

site_idSWS_FT_FI3
Number of Residues4
DetailsModified residue: {"description":"Phosphoserine; by host","evidences":[{"source":"UniProtKB","id":"P26662","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails

246704

PDB entries from 2025-12-24

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