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4MEO

Crystal Structure of the first bromodomain of human BRD4 in complex with a 2-methyl-quinoline ligand

Functional Information from PDB Data
site_idAC1
Number of Residues5
DetailsBINDING SITE FOR RESIDUE EDO A 201
ChainResidue
AILE100
AILE101
ALYS102
ATHR103
AASN135

site_idAC2
Number of Residues13
DetailsBINDING SITE FOR RESIDUE 25V A 202
ChainResidue
AVAL87
AASP88
ALEU92
AASN140
ADMS203
AHOH324
AHOH327
AHOH372
AHOH477
ATRP81
APRO82
AGLN85
APRO86

site_idAC3
Number of Residues7
DetailsBINDING SITE FOR RESIDUE DMS A 203
ChainResidue
APRO53
ATRP81
ALYS99
A25V202
AHOH341
AHOH432
AHOH468

Functional Information from PROSITE/UniProt
site_idPS00633
Number of Residues60
DetailsBROMODOMAIN_1 Bromodomain signature. AwpFqqpvDavklnlpDYYkiIktpMdmgtIkkrlenny..Ywnaqeciqdfnt.MftNCyiY
ChainResidueDetails
AALA80-TYR139

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues1
DetailsSITE: Acetylated histone binding => ECO:0000269|PubMed:22464331
ChainResidueDetails
AASN140

site_idSWS_FT_FI2
Number of Residues2
DetailsCROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2) => ECO:0007744|PubMed:28112733
ChainResidueDetails
ALYS99

222415

PDB entries from 2024-07-10

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