4MDV
Crystal structure of calcium-bound annexin (Sm)1
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0001786 | molecular_function | phosphatidylserine binding |
| A | 0005509 | molecular_function | calcium ion binding |
| A | 0005544 | molecular_function | calcium-dependent phospholipid binding |
| A | 0005545 | molecular_function | 1-phosphatidylinositol binding |
| A | 0005634 | cellular_component | nucleus |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0005886 | cellular_component | plasma membrane |
| A | 0008201 | molecular_function | heparin binding |
| A | 0008429 | molecular_function | phosphatidylethanolamine binding |
| A | 0042802 | molecular_function | identical protein binding |
| A | 0046872 | molecular_function | metal ion binding |
| B | 0001786 | molecular_function | phosphatidylserine binding |
| B | 0005509 | molecular_function | calcium ion binding |
| B | 0005544 | molecular_function | calcium-dependent phospholipid binding |
| B | 0005545 | molecular_function | 1-phosphatidylinositol binding |
| B | 0005634 | cellular_component | nucleus |
| B | 0005737 | cellular_component | cytoplasm |
| B | 0005886 | cellular_component | plasma membrane |
| B | 0008201 | molecular_function | heparin binding |
| B | 0008429 | molecular_function | phosphatidylethanolamine binding |
| B | 0042802 | molecular_function | identical protein binding |
| B | 0046872 | molecular_function | metal ion binding |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE CA A 401 |
| Chain | Residue |
| A | MET49 |
| A | GLY51 |
| A | GLY53 |
| A | THR54 |
| A | ASP93 |
| A | HOH540 |
| site_id | AC2 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE CA A 402 |
| Chain | Residue |
| A | GLU173 |
| A | HOH538 |
| A | MET121 |
| A | GLY123 |
| A | GLY125 |
| site_id | AC3 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE CA A 403 |
| Chain | Residue |
| A | LYS171 |
| A | THR174 |
| A | GLU179 |
| site_id | AC4 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE CA A 404 |
| Chain | Residue |
| A | MET302 |
| A | GLY304 |
| A | LEU305 |
| A | ASP346 |
| site_id | AC5 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE CA A 405 |
| Chain | Residue |
| A | GLY306 |
| A | ASP346 |
| A | HOH506 |
| site_id | AC6 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE CA A 406 |
| Chain | Residue |
| A | THR54 |
| A | GLU56 |
| site_id | AC7 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE CA B 401 |
| Chain | Residue |
| A | ASP128 |
| A | ASP275 |
| A | HOH502 |
| A | HOH519 |
| A | HOH552 |
| B | ASP275 |
| B | CA405 |
| site_id | AC8 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE CA B 402 |
| Chain | Residue |
| B | MET49 |
| B | GLY51 |
| B | GLY53 |
| B | ASP93 |
| B | HOH552 |
| site_id | AC9 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE CA B 403 |
| Chain | Residue |
| A | HOH556 |
| B | MET121 |
| B | GLY123 |
| B | GLY125 |
| B | GLU173 |
| site_id | BC1 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE CA B 404 |
| Chain | Residue |
| B | LYS171 |
| B | THR174 |
| B | GLU179 |
| B | HOH535 |
| B | HOH550 |
| site_id | BC2 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE CA B 405 |
| Chain | Residue |
| A | ASP275 |
| B | ASP128 |
| B | ASP275 |
| B | CA401 |
| B | HOH501 |
| B | HOH533 |
| site_id | BC3 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE CA B 406 |
| Chain | Residue |
| B | MET302 |
| B | ASP346 |
| site_id | BC4 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE CA B 407 |
| Chain | Residue |
| B | GLY306 |
| B | ASP309 |
| B | ASP346 |
Functional Information from PROSITE/UniProt
| site_id | PS00223 |
| Number of Residues | 53 |
| Details | ANNEXIN_1 Annexin repeat signature. GTnelaiiniLarRtnyErqEicqsYkslykqdLkddLksdtsGdfrkvLcqL |
| Chain | Residue | Details |
| A | GLY53-LEU105 | |
| A | GLY231-VAL283 | |
| A | GLY306-LEU358 |
