4MDT
Structure of LpxC bound to the reaction product UDP-(3-O-(R-3-hydroxymyristoyl))-glucosamine
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0008759 | molecular_function | UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity |
| A | 0009245 | biological_process | lipid A biosynthetic process |
| B | 0008759 | molecular_function | UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity |
| B | 0009245 | biological_process | lipid A biosynthetic process |
| C | 0008759 | molecular_function | UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity |
| C | 0009245 | biological_process | lipid A biosynthetic process |
| D | 0008759 | molecular_function | UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity |
| D | 0009245 | biological_process | lipid A biosynthetic process |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE ZN A 401 |
| Chain | Residue |
| A | HIS79 |
| A | HIS238 |
| A | ASP242 |
| A | PO4403 |
| site_id | AC2 |
| Number of Residues | 17 |
| Details | BINDING SITE FOR RESIDUE 24G A 402 |
| Chain | Residue |
| A | PHE192 |
| A | GLY210 |
| A | SER211 |
| A | VAL217 |
| A | LYS239 |
| A | LYS262 |
| A | GLY264 |
| A | HIS265 |
| A | PO4403 |
| A | HOH506 |
| A | HOH561 |
| B | ARG204 |
| A | LEU62 |
| A | LYS143 |
| A | ILE159 |
| A | ASP160 |
| A | PHE161 |
| site_id | AC3 |
| Number of Residues | 9 |
| Details | BINDING SITE FOR RESIDUE PO4 A 403 |
| Chain | Residue |
| A | LEU62 |
| A | GLU78 |
| A | HIS79 |
| A | THR191 |
| A | HIS238 |
| A | ASP242 |
| A | HIS265 |
| A | ZN401 |
| A | 24G402 |
| site_id | AC4 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE ZN B 401 |
| Chain | Residue |
| B | HIS79 |
| B | HIS238 |
| B | ASP242 |
| B | PO4403 |
| site_id | AC5 |
| Number of Residues | 23 |
| Details | BINDING SITE FOR RESIDUE 24G B 402 |
| Chain | Residue |
| A | ARG204 |
| B | THR60 |
| B | LEU62 |
| B | LYS143 |
| B | ILE159 |
| B | ASP160 |
| B | PHE161 |
| B | PHE192 |
| B | PHE194 |
| B | CYS207 |
| B | SER211 |
| B | VAL217 |
| B | LYS239 |
| B | LYS262 |
| B | GLY264 |
| B | HIS265 |
| B | PO4403 |
| B | HOH502 |
| B | HOH512 |
| B | HOH521 |
| B | HOH528 |
| B | HOH534 |
| B | HOH536 |
| site_id | AC6 |
| Number of Residues | 10 |
| Details | BINDING SITE FOR RESIDUE PO4 B 403 |
| Chain | Residue |
| B | LEU62 |
| B | THR76 |
| B | GLU78 |
| B | HIS79 |
| B | THR191 |
| B | HIS238 |
| B | ASP242 |
| B | HIS265 |
| B | ZN401 |
| B | 24G402 |
| site_id | AC7 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE ZN C 401 |
| Chain | Residue |
| C | HIS79 |
| C | HIS238 |
| C | ASP242 |
| C | PO4403 |
| site_id | AC8 |
| Number of Residues | 17 |
| Details | BINDING SITE FOR RESIDUE 24G C 402 |
| Chain | Residue |
| C | THR60 |
| C | LEU62 |
| C | ILE159 |
| C | PHE161 |
| C | PHE192 |
| C | ILE198 |
| C | CYS207 |
| C | GLY210 |
| C | SER211 |
| C | ALA215 |
| C | VAL217 |
| C | LYS239 |
| C | LYS262 |
| C | GLY264 |
| C | HIS265 |
| C | PO4403 |
| D | ARG204 |
| site_id | AC9 |
| Number of Residues | 8 |
| Details | BINDING SITE FOR RESIDUE PO4 C 403 |
| Chain | Residue |
| C | GLU78 |
| C | HIS79 |
| C | THR191 |
| C | HIS238 |
| C | ASP242 |
| C | HIS265 |
| C | ZN401 |
| C | 24G402 |
| site_id | BC1 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE ZN D 401 |
| Chain | Residue |
| D | PO4403 |
| D | HIS79 |
| D | HIS238 |
| D | ASP242 |
| site_id | BC2 |
| Number of Residues | 20 |
| Details | BINDING SITE FOR RESIDUE 24G D 402 |
| Chain | Residue |
| C | ARG204 |
| D | LEU18 |
| D | LEU62 |
| D | LYS143 |
| D | ILE159 |
| D | ASP160 |
| D | PHE161 |
| D | THR191 |
| D | PHE192 |
| D | PHE194 |
| D | GLY210 |
| D | SER211 |
| D | ALA215 |
| D | VAL217 |
| D | LYS239 |
| D | LYS262 |
| D | GLY264 |
| D | HIS265 |
| D | PO4403 |
| D | HOH501 |
| site_id | BC3 |
| Number of Residues | 9 |
| Details | BINDING SITE FOR RESIDUE PO4 D 403 |
| Chain | Residue |
| D | THR76 |
| D | GLU78 |
| D | HIS79 |
| D | THR191 |
| D | HIS238 |
| D | ASP242 |
| D | HIS265 |
| D | ZN401 |
| D | 24G402 |
