4MA9

Wild type Salmonella Alkyl Hydroperoxide Reductase C in its substrate-ready conformation

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004601	molecular_function	peroxidase activity
A	0005737	cellular_component	cytoplasm
A	0005829	cellular_component	cytosol
A	0006979	biological_process	response to oxidative stress
A	0008379	molecular_function	thioredoxin peroxidase activity
A	0016209	molecular_function	antioxidant activity
A	0016491	molecular_function	oxidoreductase activity
A	0042744	biological_process	hydrogen peroxide catabolic process
A	0045454	biological_process	cell redox homeostasis
A	0051920	molecular_function	peroxiredoxin activity
A	0098869	biological_process	cellular oxidant detoxification
A	0102039	molecular_function	NADH-dependent peroxiredoxin activity
B	0004601	molecular_function	peroxidase activity
B	0005737	cellular_component	cytoplasm
B	0005829	cellular_component	cytosol
B	0006979	biological_process	response to oxidative stress
B	0008379	molecular_function	thioredoxin peroxidase activity
B	0016209	molecular_function	antioxidant activity
B	0016491	molecular_function	oxidoreductase activity
B	0042744	biological_process	hydrogen peroxide catabolic process
B	0045454	biological_process	cell redox homeostasis
B	0051920	molecular_function	peroxiredoxin activity
B	0098869	biological_process	cellular oxidant detoxification
B	0102039	molecular_function	NADH-dependent peroxiredoxin activity
C	0004601	molecular_function	peroxidase activity
C	0005737	cellular_component	cytoplasm
C	0005829	cellular_component	cytosol
C	0006979	biological_process	response to oxidative stress
C	0008379	molecular_function	thioredoxin peroxidase activity
C	0016209	molecular_function	antioxidant activity
C	0016491	molecular_function	oxidoreductase activity
C	0042744	biological_process	hydrogen peroxide catabolic process
C	0045454	biological_process	cell redox homeostasis
C	0051920	molecular_function	peroxiredoxin activity
C	0098869	biological_process	cellular oxidant detoxification
C	0102039	molecular_function	NADH-dependent peroxiredoxin activity
D	0004601	molecular_function	peroxidase activity
D	0005737	cellular_component	cytoplasm
D	0005829	cellular_component	cytosol
D	0006979	biological_process	response to oxidative stress
D	0008379	molecular_function	thioredoxin peroxidase activity
D	0016209	molecular_function	antioxidant activity
D	0016491	molecular_function	oxidoreductase activity
D	0042744	biological_process	hydrogen peroxide catabolic process
D	0045454	biological_process	cell redox homeostasis
D	0051920	molecular_function	peroxiredoxin activity
D	0098869	biological_process	cellular oxidant detoxification
D	0102039	molecular_function	NADH-dependent peroxiredoxin activity
E	0004601	molecular_function	peroxidase activity
E	0005737	cellular_component	cytoplasm
E	0005829	cellular_component	cytosol
E	0006979	biological_process	response to oxidative stress
E	0008379	molecular_function	thioredoxin peroxidase activity
E	0016209	molecular_function	antioxidant activity
E	0016491	molecular_function	oxidoreductase activity
E	0042744	biological_process	hydrogen peroxide catabolic process
E	0045454	biological_process	cell redox homeostasis
E	0051920	molecular_function	peroxiredoxin activity
E	0098869	biological_process	cellular oxidant detoxification
E	0102039	molecular_function	NADH-dependent peroxiredoxin activity

Functional Information from PDB Data

site_id	AC1
Number of Residues	5
Details	BINDING SITE FOR RESIDUE CL A 201

Chain	Residue
A	SER1
A	LEU2
A	HOH1006
A	HOH1011
A	HOH1089

---

site_id	AC2
Number of Residues	6
Details	BINDING SITE FOR RESIDUE K A 202

Chain	Residue
A	HOH1087
A	HOH1087
A	THR72
A	THR72
A	HOH1064
A	HOH1064

---

site_id	AC3
Number of Residues	5
Details	BINDING SITE FOR RESIDUE GOL A 203

Chain	Residue
A	PRO39
A	PHE44
A	ARG111
A	GLU138
A	HOH1154

---

site_id	AC4
Number of Residues	5
Details	BINDING SITE FOR RESIDUE CL B 201

Chain	Residue
A	HOH1011
B	SER1
B	LEU2
B	HOH1073
B	HOH1096

---

site_id	AC5
Number of Residues	6
Details	BINDING SITE FOR RESIDUE K B 202

Chain	Residue
B	THR72
B	HOH1014
B	HOH1279
C	THR72
C	HOH1047
C	HOH1234

---

site_id	AC6
Number of Residues	5
Details	BINDING SITE FOR RESIDUE GOL B 203

Chain	Residue
B	GLU59
B	LEU63
B	LYS152
D	GLY30
D	HOH1292

---

site_id	AC7
Number of Residues	5
Details	BINDING SITE FOR RESIDUE CL C 201

Chain	Residue
C	SER1
C	LEU2
C	HOH1030
C	HOH1052
D	HOH1053

---

site_id	AC8
Number of Residues	6
Details	BINDING SITE FOR RESIDUE GOL C 202

Chain	Residue
B	PHE76
C	PRO39
C	GLU114
C	LEU116
C	GLU138
C	HOH1253

---

site_id	AC9
Number of Residues	4
Details	BINDING SITE FOR RESIDUE CL D 201

Chain	Residue
D	SER1
D	LEU2
D	HOH1053
D	HOH1054

---

site_id	BC1
Number of Residues	6
Details	BINDING SITE FOR RESIDUE K D 202

Chain	Residue
D	THR72
D	HOH1195
D	HOH1373
E	THR72
E	HOH1106
E	HOH1261

---

site_id	BC2
Number of Residues	8
Details	BINDING SITE FOR RESIDUE GOL D 203

Chain	Residue
B	LEU63
B	GLN155
B	HOH1114
B	HOH1299
D	ARG31
D	GLN61
D	GLY64
D	HOH1141

---

site_id	BC3
Number of Residues	5
Details	BINDING SITE FOR RESIDUE CL E 201

Chain	Residue
E	SER1
E	LEU2
E	ILE133
E	HOH1218
E	HOH1465

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	775
Details	Domain: {"description":"Thioredoxin","evidences":[{"source":"PROSITE-ProRule","id":"PRU00691","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	5
Details	Active site: {"description":"Cysteine sulfenic acid (-SOH) intermediate","evidences":[{"source":"PubMed","id":"18986167","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

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