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4M9X

Crystal structure of CED-4 bound CED-3 fragment

Functional Information from GO Data
ChainGOidnamespacecontents
A0000287molecular_functionmagnesium ion binding
A0005515molecular_functionprotein binding
A0005524molecular_functionATP binding
A0005634cellular_componentnucleus
A0005737cellular_componentcytoplasm
A0005739cellular_componentmitochondrion
A0005829cellular_componentcytosol
A0006915biological_processapoptotic process
A0006919biological_processactivation of cysteine-type endopeptidase activity involved in apoptotic process
A0008303cellular_componentcaspase complex
A0008361biological_processregulation of cell size
A0008656molecular_functioncysteine-type endopeptidase activator activity involved in apoptotic process
A0009792biological_processembryo development ending in birth or egg hatching
A0010954biological_processpositive regulation of protein processing
A0016020cellular_componentmembrane
A0016505molecular_functionpeptidase activator activity involved in apoptotic process
A0030042biological_processactin filament depolymerization
A0030155biological_processregulation of cell adhesion
A0031647biological_processregulation of protein stability
A0032991cellular_componentprotein-containing complex
A0040034biological_processregulation of development, heterochronic
A0042802molecular_functionidentical protein binding
A0042981biological_processregulation of apoptotic process
A0043065biological_processpositive regulation of apoptotic process
A0043531molecular_functionADP binding
A0046716biological_processmuscle cell cellular homeostasis
A0046872molecular_functionmetal ion binding
A0048471cellular_componentperinuclear region of cytoplasm
A0048598biological_processembryonic morphogenesis
A0050829biological_processdefense response to Gram-negative bacterium
A0051432molecular_functionBH1 domain binding
A0051434molecular_functionBH3 domain binding
A0061133molecular_functionendopeptidase activator activity
A0089720molecular_functioncaspase binding
A0097202biological_processactivation of cysteine-type endopeptidase activity
A1900118biological_processnegative regulation of execution phase of apoptosis
A1902742biological_processapoptotic process involved in development
A1904747biological_processpositive regulation of apoptotic process involved in development
A1905808biological_processpositive regulation of synapse pruning
B0000287molecular_functionmagnesium ion binding
B0005515molecular_functionprotein binding
B0005524molecular_functionATP binding
B0005634cellular_componentnucleus
B0005737cellular_componentcytoplasm
B0005739cellular_componentmitochondrion
B0005829cellular_componentcytosol
B0006915biological_processapoptotic process
B0006919biological_processactivation of cysteine-type endopeptidase activity involved in apoptotic process
B0008303cellular_componentcaspase complex
B0008361biological_processregulation of cell size
B0008656molecular_functioncysteine-type endopeptidase activator activity involved in apoptotic process
B0009792biological_processembryo development ending in birth or egg hatching
B0010954biological_processpositive regulation of protein processing
B0016020cellular_componentmembrane
B0016505molecular_functionpeptidase activator activity involved in apoptotic process
B0030042biological_processactin filament depolymerization
B0030155biological_processregulation of cell adhesion
B0031647biological_processregulation of protein stability
B0032991cellular_componentprotein-containing complex
B0040034biological_processregulation of development, heterochronic
B0042802molecular_functionidentical protein binding
B0042981biological_processregulation of apoptotic process
B0043065biological_processpositive regulation of apoptotic process
B0043531molecular_functionADP binding
B0046716biological_processmuscle cell cellular homeostasis
B0046872molecular_functionmetal ion binding
B0048471cellular_componentperinuclear region of cytoplasm
B0048598biological_processembryonic morphogenesis
B0050829biological_processdefense response to Gram-negative bacterium
B0051432molecular_functionBH1 domain binding
B0051434molecular_functionBH3 domain binding
B0061133molecular_functionendopeptidase activator activity
B0089720molecular_functioncaspase binding
B0097202biological_processactivation of cysteine-type endopeptidase activity
B1900118biological_processnegative regulation of execution phase of apoptosis
B1902742biological_processapoptotic process involved in development
B1904747biological_processpositive regulation of apoptotic process involved in development
B1905808biological_processpositive regulation of synapse pruning
Functional Information from PDB Data
site_idAC1
Number of Residues3
DetailsBINDING SITE FOR RESIDUE MG A 601
ChainResidue
ASER166
AASP250
AATP602

site_idAC2
Number of Residues18
DetailsBINDING SITE FOR RESIDUE ATP A 602
ChainResidue
AVAL167
AGLN171
AARG273
APHE301
ATYR305
APRO330
AALA331
AMET334
ATHR367
APRO368
ATYR369
AMG601
ATYR131
AALA161
AGLY162
AGLY164
ALYS165
ASER166

site_idAC3
Number of Residues3
DetailsBINDING SITE FOR RESIDUE MG B 601
ChainResidue
BSER166
BASP250
BATP602

site_idAC4
Number of Residues16
DetailsBINDING SITE FOR RESIDUE ATP B 602
ChainResidue
BMET128
BTYR131
BALA161
BGLY162
BGLY164
BLYS165
BSER166
BVAL167
BARG273
BPRO330
BALA331
BMET334
BTHR367
BPRO368
BTYR369
BMG601

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues4
DetailsBINDING: BINDING => ECO:0000269|PubMed:16208361, ECO:0000269|PubMed:20434985, ECO:0000269|PubMed:24065769, ECO:0007744|PDB:2A5Y, ECO:0007744|PDB:3LQQ, ECO:0007744|PDB:3LQR, ECO:0007744|PDB:4M9S, ECO:0007744|PDB:4M9X, ECO:0007744|PDB:4M9Y, ECO:0007744|PDB:4M9Z
ChainResidueDetails
ATYR131
AGLY162
BTYR131
BGLY162

site_idSWS_FT_FI2
Number of Residues2
DetailsBINDING: BINDING => ECO:0000269|PubMed:16208361, ECO:0000269|PubMed:20434985
ChainResidueDetails
ASER166
BSER166

site_idSWS_FT_FI3
Number of Residues2
DetailsBINDING: BINDING => ECO:0000269|PubMed:24065769, ECO:0007744|PDB:4M9S
ChainResidueDetails
AGLN171
BGLN171

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PDB entries from 2024-07-10

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