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SummaryStructural detailsExperimental detailsFunctional detailsSequence NeighborHistoryDownloads

4M9S

crystal structure of CED-4 bound CED-3 fragment

Functional Information from GO Data
ChainGOidnamespacecontents
A0000166molecular_functionnucleotide binding
A0000287molecular_functionmagnesium ion binding
A0005515molecular_functionprotein binding
A0005524molecular_functionATP binding
A0005634cellular_componentnucleus
A0005739cellular_componentmitochondrion
A0005829cellular_componentcytosol
A0006915biological_processapoptotic process
A0008303cellular_componentcaspase complex
A0008361biological_processregulation of cell size
A0008656molecular_functioncysteine-type endopeptidase activator activity involved in apoptotic process
A0009792biological_processembryo development ending in birth or egg hatching
A0010954biological_processpositive regulation of protein processing
A0016020cellular_componentmembrane
A0016505molecular_functionpeptidase activator activity involved in apoptotic process
A0030042biological_processactin filament depolymerization
A0030155biological_processregulation of cell adhesion
A0031647biological_processregulation of protein stability
A0032991cellular_componentprotein-containing complex
A0040034biological_processregulation of development, heterochronic
A0042802molecular_functionidentical protein binding
A0042981biological_processregulation of apoptotic process
A0043065biological_processpositive regulation of apoptotic process
A0043531molecular_functionADP binding
A0046716biological_processmuscle cell cellular homeostasis
A0046872molecular_functionmetal ion binding
A0048471cellular_componentperinuclear region of cytoplasm
A0048598biological_processembryonic morphogenesis
A0050829biological_processdefense response to Gram-negative bacterium
A0051432molecular_functionBH1 domain binding
A0051434molecular_functionBH3 domain binding
A0061133molecular_functionendopeptidase activator activity
A0089720molecular_functioncaspase binding
A0140608molecular_functioncysteine-type endopeptidase activator activity
A1900118biological_processnegative regulation of execution phase of apoptosis
A1902742biological_processapoptotic process involved in development
A1904747biological_processpositive regulation of apoptotic process involved in development
A1905808biological_processpositive regulation of synapse pruning
B0000166molecular_functionnucleotide binding
B0000287molecular_functionmagnesium ion binding
B0005515molecular_functionprotein binding
B0005524molecular_functionATP binding
B0005634cellular_componentnucleus
B0005739cellular_componentmitochondrion
B0005829cellular_componentcytosol
B0006915biological_processapoptotic process
B0008303cellular_componentcaspase complex
B0008361biological_processregulation of cell size
B0008656molecular_functioncysteine-type endopeptidase activator activity involved in apoptotic process
B0009792biological_processembryo development ending in birth or egg hatching
B0010954biological_processpositive regulation of protein processing
B0016020cellular_componentmembrane
B0016505molecular_functionpeptidase activator activity involved in apoptotic process
B0030042biological_processactin filament depolymerization
B0030155biological_processregulation of cell adhesion
B0031647biological_processregulation of protein stability
B0032991cellular_componentprotein-containing complex
B0040034biological_processregulation of development, heterochronic
B0042802molecular_functionidentical protein binding
B0042981biological_processregulation of apoptotic process
B0043065biological_processpositive regulation of apoptotic process
B0043531molecular_functionADP binding
B0046716biological_processmuscle cell cellular homeostasis
B0046872molecular_functionmetal ion binding
B0048471cellular_componentperinuclear region of cytoplasm
B0048598biological_processembryonic morphogenesis
B0050829biological_processdefense response to Gram-negative bacterium
B0051432molecular_functionBH1 domain binding
B0051434molecular_functionBH3 domain binding
B0061133molecular_functionendopeptidase activator activity
B0089720molecular_functioncaspase binding
B0140608molecular_functioncysteine-type endopeptidase activator activity
B1900118biological_processnegative regulation of execution phase of apoptosis
B1902742biological_processapoptotic process involved in development
B1904747biological_processpositive regulation of apoptotic process involved in development
B1905808biological_processpositive regulation of synapse pruning
C0000166molecular_functionnucleotide binding
C0000287molecular_functionmagnesium ion binding
C0005515molecular_functionprotein binding
C0005524molecular_functionATP binding
C0005634cellular_componentnucleus
C0005739cellular_componentmitochondrion
C0005829cellular_componentcytosol
C0006915biological_processapoptotic process
C0008303cellular_componentcaspase complex
C0008361biological_processregulation of cell size
C0008656molecular_functioncysteine-type endopeptidase activator activity involved in apoptotic process
C0009792biological_processembryo development ending in birth or egg hatching
C0010954biological_processpositive regulation of protein processing
C0016020cellular_componentmembrane
C0016505molecular_functionpeptidase activator activity involved in apoptotic process
C0030042biological_processactin filament depolymerization
C0030155biological_processregulation of cell adhesion
C0031647biological_processregulation of protein stability
C0032991cellular_componentprotein-containing complex
C0040034biological_processregulation of development, heterochronic
C0042802molecular_functionidentical protein binding
C0042981biological_processregulation of apoptotic process
C0043065biological_processpositive regulation of apoptotic process
C0043531molecular_functionADP binding
C0046716biological_processmuscle cell cellular homeostasis
C0046872molecular_functionmetal ion binding
C0048471cellular_componentperinuclear region of cytoplasm
C0048598biological_processembryonic morphogenesis
C0050829biological_processdefense response to Gram-negative bacterium
C0051432molecular_functionBH1 domain binding
C0051434molecular_functionBH3 domain binding
C0061133molecular_functionendopeptidase activator activity
C0089720molecular_functioncaspase binding
C0140608molecular_functioncysteine-type endopeptidase activator activity
C1900118biological_processnegative regulation of execution phase of apoptosis
C1902742biological_processapoptotic process involved in development
C1904747biological_processpositive regulation of apoptotic process involved in development
C1905808biological_processpositive regulation of synapse pruning
D0000166molecular_functionnucleotide binding
D0000287molecular_functionmagnesium ion binding
D0005515molecular_functionprotein binding
D0005524molecular_functionATP binding
D0005634cellular_componentnucleus
D0005739cellular_componentmitochondrion
D0005829cellular_componentcytosol
D0006915biological_processapoptotic process
D0008303cellular_componentcaspase complex
D0008361biological_processregulation of cell size
D0008656molecular_functioncysteine-type endopeptidase activator activity involved in apoptotic process
D0009792biological_processembryo development ending in birth or egg hatching
D0010954biological_processpositive regulation of protein processing
D0016020cellular_componentmembrane
D0016505molecular_functionpeptidase activator activity involved in apoptotic process
D0030042biological_processactin filament depolymerization
D0030155biological_processregulation of cell adhesion
D0031647biological_processregulation of protein stability
D0032991cellular_componentprotein-containing complex
D0040034biological_processregulation of development, heterochronic
D0042802molecular_functionidentical protein binding
D0042981biological_processregulation of apoptotic process
D0043065biological_processpositive regulation of apoptotic process
D0043531molecular_functionADP binding
D0046716biological_processmuscle cell cellular homeostasis
D0046872molecular_functionmetal ion binding
D0048471cellular_componentperinuclear region of cytoplasm
D0048598biological_processembryonic morphogenesis
D0050829biological_processdefense response to Gram-negative bacterium
D0051432molecular_functionBH1 domain binding
D0051434molecular_functionBH3 domain binding
D0061133molecular_functionendopeptidase activator activity
D0089720molecular_functioncaspase binding
D0140608molecular_functioncysteine-type endopeptidase activator activity
D1900118biological_processnegative regulation of execution phase of apoptosis
D1902742biological_processapoptotic process involved in development
D1904747biological_processpositive regulation of apoptotic process involved in development
D1905808biological_processpositive regulation of synapse pruning
Functional Information from PDB Data
site_idAC1
Number of Residues4
DetailsBINDING SITE FOR RESIDUE MG A 601
ChainResidue
ASER166
AASP250
ATHR271
AATP602
site_idAC2
Number of Residues16
DetailsBINDING SITE FOR RESIDUE ATP A 602
ChainResidue
ASER166
AVAL167
AARG273
APHE301
ATYR305
APRO330
AALA331
AMSE334
APRO368
ATYR369
AMG601
ATYR131
AALA161
AGLY162
AGLY164
ALYS165
site_idAC3
Number of Residues3
DetailsBINDING SITE FOR RESIDUE MG B 601
ChainResidue
BSER166
BASP250
BATP602
site_idAC4
Number of Residues16
DetailsBINDING SITE FOR RESIDUE ATP B 602
ChainResidue
BTYR131
BALA161
BGLY162
BGLY164
BLYS165
BSER166
BVAL167
BARG273
BTYR305
BPRO330
BALA331
BMSE334
BTHR367
BPRO368
BTYR369
BMG601
site_idAC5
Number of Residues3
DetailsBINDING SITE FOR RESIDUE MG C 601
ChainResidue
CSER166
CLYS191
CATP602
site_idAC6
Number of Residues17
DetailsBINDING SITE FOR RESIDUE ATP C 602
ChainResidue
CMSE128
CTYR131
CGLY162
CGLY164
CLYS165
CSER166
CVAL167
CARG273
CPHE301
CTYR305
CPRO330
CALA331
CMSE334
CTHR367
CPRO368
CTYR369
CMG601
site_idAC7
Number of Residues3
DetailsBINDING SITE FOR RESIDUE MG D 601
ChainResidue
DSER166
DASP250
DATP602
site_idAC8
Number of Residues17
DetailsBINDING SITE FOR RESIDUE ATP D 602
ChainResidue
DMSE128
DTYR131
DGLY162
DGLY164
DLYS165
DSER166
DVAL167
DGLN171
DARG273
DPHE301
DPRO330
DALA331
DMSE334
DTHR367
DPRO368
DTYR369
DMG601
Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues4
DetailsBinding site: {"evidences":[{"source":"PubMed","id":"16208361","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"20434985","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"24065769","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"2A5Y","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3LQQ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3LQR","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4M9S","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4M9X","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4M9Y","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4M9Z","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI2
Number of Residues4
DetailsBinding site: {"evidences":[{"source":"PubMed","id":"16208361","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"20434985","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"24065769","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"37402593","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"2A5Y","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3LQQ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4M9S","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4M9X","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4M9Y","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8JNS","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8JO0","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8JOL","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI3
Number of Residues14
DetailsBinding site: {"evidences":[{"source":"PubMed","id":"16208361","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"20434985","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"24065769","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"37402593","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"2A5Y","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3LQQ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3LQR","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4M9S","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4M9X","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4M9Y","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8JNS","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8JO0","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8JOL","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI4
Number of Residues4
DetailsBinding site: {"evidences":[{"source":"PubMed","id":"16208361","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"20434985","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"24065769","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"37402593","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"2A5Y","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3LQQ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3LQR","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4M9X","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4M9Y","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4M9Z","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8JNS","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8JO0","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8JOL","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI5
Number of Residues4
DetailsBinding site: {"evidences":[{"source":"PubMed","id":"16208361","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"20434985","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"24065769","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"37402593","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"2A5Y","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3LQQ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3LQR","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4M9S","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4M9X","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4M9Y","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8JO0","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8JOL","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI6
Number of Residues4
DetailsBinding site: {"evidences":[{"source":"PubMed","id":"20434985","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"3LQR","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails

246704

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