4M8L
crystal structure of RpiA-R5P complex
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004751 | molecular_function | ribose-5-phosphate isomerase activity |
| A | 0005829 | cellular_component | cytosol |
| A | 0006014 | biological_process | D-ribose metabolic process |
| A | 0006098 | biological_process | pentose-phosphate shunt |
| A | 0009052 | biological_process | pentose-phosphate shunt, non-oxidative branch |
| A | 0016853 | molecular_function | isomerase activity |
| A | 0044281 | biological_process | small molecule metabolic process |
| B | 0004751 | molecular_function | ribose-5-phosphate isomerase activity |
| B | 0005829 | cellular_component | cytosol |
| B | 0006014 | biological_process | D-ribose metabolic process |
| B | 0006098 | biological_process | pentose-phosphate shunt |
| B | 0009052 | biological_process | pentose-phosphate shunt, non-oxidative branch |
| B | 0016853 | molecular_function | isomerase activity |
| B | 0044281 | biological_process | small molecule metabolic process |
| C | 0004751 | molecular_function | ribose-5-phosphate isomerase activity |
| C | 0005829 | cellular_component | cytosol |
| C | 0006014 | biological_process | D-ribose metabolic process |
| C | 0006098 | biological_process | pentose-phosphate shunt |
| C | 0009052 | biological_process | pentose-phosphate shunt, non-oxidative branch |
| C | 0016853 | molecular_function | isomerase activity |
| C | 0044281 | biological_process | small molecule metabolic process |
| D | 0004751 | molecular_function | ribose-5-phosphate isomerase activity |
| D | 0005829 | cellular_component | cytosol |
| D | 0006014 | biological_process | D-ribose metabolic process |
| D | 0006098 | biological_process | pentose-phosphate shunt |
| D | 0009052 | biological_process | pentose-phosphate shunt, non-oxidative branch |
| D | 0016853 | molecular_function | isomerase activity |
| D | 0044281 | biological_process | small molecule metabolic process |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 19 |
| Details | BINDING SITE FOR RESIDUE 5RP A 301 |
| Chain | Residue |
| A | THR34 |
| A | GLY101 |
| A | GLY102 |
| A | GLY103 |
| A | ALA104 |
| A | ALA105 |
| A | GLU109 |
| A | LYS127 |
| A | HOH425 |
| A | HOH457 |
| A | HOH469 |
| A | GLY35 |
| A | SER36 |
| A | THR37 |
| A | ASP87 |
| A | GLY88 |
| A | ALA89 |
| A | ASP90 |
| A | LYS100 |
| site_id | AC2 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE ARF A 302 |
| Chain | Residue |
| A | VAL113 |
| A | GLU189 |
| A | PHE204 |
| A | LYS207 |
| A | HOH407 |
| A | HOH480 |
| site_id | AC3 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE ARF A 303 |
| Chain | Residue |
| A | HIS95 |
| A | ASP183 |
| A | HOH492 |
| site_id | AC4 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE ARF A 304 |
| Chain | Residue |
| A | LYS67 |
| A | PHE71 |
| A | ASP72 |
| site_id | AC5 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE ARF A 305 |
| Chain | Residue |
| A | HIS95 |
| A | GLU97 |
| site_id | AC6 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE ARF A 307 |
| Chain | Residue |
| A | ASP61 |
| A | GLY103 |
| A | HOH489 |
| site_id | AC7 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE ARF A 308 |
| Chain | Residue |
| A | SER36 |
| A | GLY39 |
| A | PHE40 |
| A | LYS65 |
| A | HOH427 |
| A | HOH432 |
| A | HOH496 |
| site_id | AC8 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE ARF A 309 |
| Chain | Residue |
| A | HOH420 |
| A | HOH421 |
| site_id | AC9 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE ARF A 311 |
| Chain | Residue |
| A | ASN94 |
| A | HIS95 |
| A | LYS96 |
| site_id | BC1 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE ARF A 312 |
| Chain | Residue |
| A | GLU189 |
| A | ASN193 |
| A | HOH480 |
| C | GLN194 |
| C | THR196 |
| site_id | BC2 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE ARF A 313 |
| Chain | Residue |
| A | LYS67 |
| A | ASP72 |
| A | VAL73 |
| site_id | BC3 |
| Number of Residues | 1 |
| Details | BINDING SITE FOR RESIDUE ARF A 314 |
| Chain | Residue |
| A | HOH433 |
| site_id | BC4 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE ARF A 315 |
| Chain | Residue |
| A | ARG64 |
| A | LYS67 |
| A | ALA68 |
| A | LEU206 |
| site_id | BC5 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE ARF A 316 |
| Chain | Residue |
| A | ILE52 |
| A | LYS53 |
| A | PHE71 |
| A | ASP72 |
| A | HOH455 |
| site_id | BC6 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE CL A 317 |
| Chain | Residue |
| A | ARG146 |
| B | GLN159 |
| site_id | BC7 |
| Number of Residues | 18 |
| Details | BINDING SITE FOR RESIDUE 5RP B 301 |
| Chain | Residue |
| B | THR34 |
| B | GLY35 |
| B | SER36 |
| B | THR37 |
| B | ASP87 |
| B | GLY88 |
| B | ALA89 |
| B | ASP90 |
| B | LYS100 |
| B | GLY101 |
| B | GLY102 |
| B | GLY103 |
| B | ALA104 |
| B | ALA105 |
| B | GLU109 |
| B | LYS127 |
| B | HOH407 |
| B | HOH456 |
| site_id | BC8 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE ARF B 302 |
| Chain | Residue |
| B | THR34 |
| B | GLY103 |
| B | HOH463 |
| site_id | BC9 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE ARF B 303 |
| Chain | Residue |
| B | HIS95 |
| B | LYS96 |
| B | ALA209 |
| B | HOH423 |
| B | HOH449 |
| site_id | CC1 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE ARF B 304 |
| Chain | Residue |
| B | HOH405 |
| B | ALA68 |
| B | LYS207 |
| B | PRO208 |
| B | ASP210 |
| B | ARF308 |
| site_id | CC2 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE ARF B 305 |
| Chain | Residue |
| B | HIS95 |
| B | HOH426 |
| B | HOH474 |
| site_id | CC3 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE ARF B 306 |
| Chain | Residue |
| B | SER58 |
| B | ALA105 |
| B | THR107 |
| B | ARG108 |
| B | ASP169 |
| B | ASN170 |
| site_id | CC4 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE ARF B 307 |
| Chain | Residue |
| B | LYS67 |
| B | PHE71 |
| B | ASP72 |
| B | HOH459 |
| site_id | CC5 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE ARF B 308 |
| Chain | Residue |
| B | ALA116 |
| B | LYS117 |
| B | LYS207 |
| B | ASP210 |
| B | ARF304 |
| site_id | CC6 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE ARF B 309 |
| Chain | Residue |
| B | ARG64 |
| B | LYS67 |
| B | LEU206 |
| site_id | CC7 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE ARF B 310 |
| Chain | Residue |
| B | ASP75 |
| B | ASN77 |
| B | HOH433 |
| B | HOH455 |
| D | PRO143 |
| site_id | CC8 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE ARF B 311 |
| Chain | Residue |
| B | LYS110 |
| B | GLU189 |
| B | ASN193 |
| B | ARF313 |
| D | GLN194 |
| D | THR196 |
| site_id | CC9 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE ARF B 312 |
| Chain | Residue |
| B | HIS95 |
| B | GLU97 |
| site_id | DC1 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE ARF B 313 |
| Chain | Residue |
| B | ASN193 |
| B | ARF311 |
| D | ASN193 |
| D | GLN194 |
| D | ILE195 |
| site_id | DC2 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE ARF B 314 |
| Chain | Residue |
| A | GLN159 |
| A | PRO160 |
| B | ALA150 |
| B | ARG151 |
| B | VAL154 |
| B | HOH402 |
| site_id | DC3 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE CL B 315 |
| Chain | Residue |
| B | ASP61 |
| B | ARG64 |
| B | ASN184 |
| B | LEU186 |
| site_id | DC4 |
| Number of Residues | 1 |
| Details | BINDING SITE FOR RESIDUE CL B 316 |
| Chain | Residue |
| B | GLU164 |
| site_id | DC5 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE CL B 317 |
| Chain | Residue |
| B | ARG49 |
| B | ILE52 |
| B | LYS53 |
| site_id | DC6 |
| Number of Residues | 19 |
| Details | BINDING SITE FOR RESIDUE 5RP C 301 |
| Chain | Residue |
| C | THR34 |
| C | GLY35 |
| C | SER36 |
| C | THR37 |
| C | ASP87 |
| C | GLY88 |
| C | ASP90 |
| C | LYS100 |
| C | GLY101 |
| C | GLY102 |
| C | GLY103 |
| C | ALA104 |
| C | ALA105 |
| C | GLU109 |
| C | LYS127 |
| C | ARF307 |
| C | HOH409 |
| C | HOH422 |
| C | HOH455 |
| site_id | DC7 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE ARF C 302 |
| Chain | Residue |
| C | SER147 |
| C | ALA150 |
| C | ARG151 |
| C | VAL154 |
| C | ARF304 |
| C | HOH411 |
| site_id | DC8 |
| Number of Residues | 8 |
| Details | BINDING SITE FOR RESIDUE ARF C 303 |
| Chain | Residue |
| A | MET144 |
| C | VAL56 |
| C | SER57 |
| C | VAL73 |
| C | VAL74 |
| C | ASP75 |
| C | LEU76 |
| C | HOH405 |
| site_id | DC9 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE ARF C 304 |
| Chain | Residue |
| C | ALA150 |
| C | ARG151 |
| C | VAL154 |
| C | VAL154 |
| C | ARF302 |
| site_id | EC1 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE ARF C 306 |
| Chain | Residue |
| C | GLU60 |
| C | ARG108 |
| C | ASP169 |
| C | ARF308 |
| site_id | EC2 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE ARF C 307 |
| Chain | Residue |
| C | ASP90 |
| C | PHE135 |
| C | 5RP301 |
| C | HOH455 |
| site_id | EC3 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE ARF C 308 |
| Chain | Residue |
| C | ARF306 |
| C | ARF311 |
| C | HOH402 |
| C | HOH443 |
| site_id | EC4 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE ARF C 309 |
| Chain | Residue |
| C | PRO143 |
| C | GLY171 |
| site_id | EC5 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE ARF C 310 |
| Chain | Residue |
| C | GLU60 |
| C | ASP61 |
| C | GLY103 |
| C | ASP169 |
| site_id | EC6 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE ARF C 311 |
| Chain | Residue |
| C | HIS95 |
| C | GLU97 |
| C | ALA205 |
| C | PRO208 |
| C | ARF308 |
| site_id | EC7 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE ARF C 312 |
| Chain | Residue |
| C | ARG163 |
| C | THR166 |
| C | HOH420 |
| site_id | EC8 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE CL C 313 |
| Chain | Residue |
| C | ARG151 |
| C | GLN152 |
| site_id | EC9 |
| Number of Residues | 15 |
| Details | BINDING SITE FOR RESIDUE 5RP D 301 |
| Chain | Residue |
| D | THR34 |
| D | GLY35 |
| D | SER36 |
| D | THR37 |
| D | ASP87 |
| D | GLY88 |
| D | ASP90 |
| D | LYS100 |
| D | GLY101 |
| D | GLY103 |
| D | ALA105 |
| D | GLU109 |
| D | LYS127 |
| D | HOH417 |
| D | HOH430 |
| site_id | FC1 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE ARF D 302 |
| Chain | Residue |
| D | LYS110 |
| D | GLU189 |
| D | PHE204 |
| D | ALA205 |
| D | LEU206 |
| D | LYS207 |
| D | HOH435 |
| site_id | FC2 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE ARF D 303 |
| Chain | Residue |
| D | TYR148 |
| D | GLN152 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 4 |
| Details | ACT_SITE: Proton acceptor => ECO:0000255|HAMAP-Rule:MF_00170 |
| Chain | Residue | Details |
| A | GLU109 | |
| B | GLU109 | |
| C | GLU109 | |
| D | GLU109 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 16 |
| Details | BINDING: BINDING => ECO:0000255|HAMAP-Rule:MF_00170 |
| Chain | Residue | Details |
| A | THR34 | |
| C | ASP87 | |
| C | LYS100 | |
| C | LYS127 | |
| D | THR34 | |
| D | ASP87 | |
| D | LYS100 | |
| D | LYS127 | |
| A | ASP87 | |
| A | LYS100 | |
| A | LYS127 | |
| B | THR34 | |
| B | ASP87 | |
| B | LYS100 | |
| B | LYS127 | |
| C | THR34 |
