4M80
The structure of E292S glycosynthase variant of exo-1,3-beta-glucanase from Candida albicans at 1.85A resolution
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0000272 | biological_process | polysaccharide catabolic process |
| A | 0004338 | molecular_function | glucan exo-1,3-beta-glucosidase activity |
| A | 0004553 | molecular_function | hydrolase activity, hydrolyzing O-glycosyl compounds |
| A | 0005576 | cellular_component | extracellular region |
| A | 0005975 | biological_process | carbohydrate metabolic process |
| A | 0007155 | biological_process | cell adhesion |
| A | 0009251 | biological_process | glucan catabolic process |
| A | 0009986 | cellular_component | cell surface |
| A | 0016740 | molecular_function | transferase activity |
| A | 0016787 | molecular_function | hydrolase activity |
| A | 0016798 | molecular_function | hydrolase activity, acting on glycosyl bonds |
| A | 0031505 | biological_process | fungal-type cell wall organization |
| A | 0031589 | biological_process | cell-substrate adhesion |
| A | 0044011 | biological_process | single-species biofilm formation on inanimate substrate |
| A | 0044042 | biological_process | glucan metabolic process |
| A | 0044407 | biological_process | single-species biofilm formation in or on host organism |
| A | 0044650 | biological_process | adhesion of symbiont to host cell |
| A | 0050839 | molecular_function | cell adhesion molecule binding |
| A | 0071555 | biological_process | cell wall organization |
| A | 1903561 | cellular_component | extracellular vesicle |
Functional Information from PROSITE/UniProt
| site_id | PS00659 |
| Number of Residues | 10 |
| Details | GLYCOSYL_HYDROL_F5 Glycosyl hydrolases family 5 signature. IGIELLNEPL |
| Chain | Residue | Details |
| A | ILE185-LEU194 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 1 |
| Details | Active site: {"description":"Proton donor","evidences":[{"source":"UniProtKB","id":"O85465","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 1 |
| Details | Active site: {"description":"Nucleophile","evidences":[{"source":"PubMed","id":"9013549","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 5 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"20875088","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
Catalytic Information from CSA
| site_id | MCSA1 |
| Number of Residues | 2 |
| Details | M-CSA 831 |
| Chain | Residue | Details |
| A | GLU192 | activator, increase nucleophilicity, promote heterolysis, proton acceptor, proton donor |
| A | SER292 | covalently attached, nucleofuge, nucleophile |
