4M7B

Human tankyrase 2 - catalytic Parp domain in complex with an inhibitor UPF1854

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003950	molecular_function	NAD+-protein poly-ADP-ribosyltransferase activity
C	0003950	molecular_function	NAD+-protein poly-ADP-ribosyltransferase activity

Functional Information from PDB Data

site_id	AC1
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN A 1201

Chain	Residue
A	CYS1081
A	HIS1084
A	CYS1089
A	CYS1092

---

site_id	AC2
Number of Residues	11
Details	BINDING SITE FOR RESIDUE 28C A 1202

Chain	Residue
A	TYR1050
A	TYR1060
A	SER1068
A	TYR1071
A	ILE1075
A	HOH1349
A	PHE1030
A	HIS1031
A	GLY1032
A	PRO1034
A	ALA1049

---

site_id	AC3
Number of Residues	8
Details	BINDING SITE FOR RESIDUE SO4 A 1203

Chain	Residue
A	ARG977
A	HIS979
A	ARG980
A	LYS1067
A	GLN1070
A	HOH1345
A	HOH1364
A	HOH1371

---

site_id	AC4
Number of Residues	6
Details	BINDING SITE FOR RESIDUE SO4 A 1204

Chain	Residue
A	ASN990
A	ARG991
A	PRO1160
A	GLU1161
A	HOH1358
A	HOH1425

---

site_id	AC5
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN C 1201

Chain	Residue
C	CYS1081
C	HIS1084
C	CYS1089
C	CYS1092

---

site_id	AC6
Number of Residues	9
Details	BINDING SITE FOR RESIDUE 28C C 1202

Chain	Residue
C	PHE1030
C	HIS1031
C	GLY1032
C	PRO1034
C	PHE1035
C	TYR1050
C	TYR1060
C	SER1068
C	TYR1071

---

site_id	AC7
Number of Residues	7
Details	BINDING SITE FOR RESIDUE SO4 C 1203

Chain	Residue
C	ARG977
C	HIS979
C	ARG980
C	LYS1067
C	GLN1070
C	HOH1374
C	HOH1379

---

site_id	AC8
Number of Residues	5
Details	BINDING SITE FOR RESIDUE SO4 C 1204

Chain	Residue
C	ASN990
C	ARG991
C	ARG1159
C	PRO1160
C	GLU1161

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	8
Details	BINDING: BINDING => ECO:0000250|UniProtKB:O95271

Chain	Residue	Details
A	CYS1081
A	HIS1084
A	CYS1089
A	CYS1092
C	CYS1081
C	HIS1084
C	CYS1089
C	CYS1092

---