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4M6X

Mutant structure of methyltransferase from Streptomyces hygroscopicus complexed with S-adenosyl-L-homocysteine and methylphenylpyruvic acid

Functional Information from GO Data
ChainGOidnamespacecontents
A0008168molecular_functionmethyltransferase activity
A0009058biological_processbiosynthetic process
A0017000biological_processantibiotic biosynthetic process
A0032259biological_processmethylation
B0008168molecular_functionmethyltransferase activity
B0009058biological_processbiosynthetic process
B0017000biological_processantibiotic biosynthetic process
B0032259biological_processmethylation
Functional Information from PDB Data
site_idAC1
Number of Residues16
DetailsBINDING SITE FOR RESIDUE SAH A 401
ChainResidue
ASER140
AALA218
AARG219
APHE239
AMET240
AMET241
AHOH521
AHOH624
AGLY166
AGLY168
AARG172
AASP189
AILE190
AALA191
AGLY216
AASP217

site_idAC2
Number of Residues9
DetailsBINDING SITE FOR RESIDUE 56D A 402
ChainResidue
ATRP99
AARG127
ACYS136
AMET240
AHIS243
AASP272
AHIS295
AFE403
AHOH502

site_idAC3
Number of Residues5
DetailsBINDING SITE FOR RESIDUE FE A 403
ChainResidue
AHIS243
AHIS295
A56D402
AHOH501
AHOH502

site_idAC4
Number of Residues8
DetailsBINDING SITE FOR RESIDUE HF2 A 404
ChainResidue
AASP309
APHE312
ACYS319
ALYS321
ALYS322
AHOH571
BLYS322
BHF2404

site_idAC5
Number of Residues4
DetailsBINDING SITE FOR RESIDUE CA A 405
ChainResidue
AASP306
AASP309
BASP306
BASP309

site_idAC6
Number of Residues5
DetailsBINDING SITE FOR RESIDUE CA A 406
ChainResidue
ASER-1
AHIS0
AMET1
ASER2
BALA204

site_idAC7
Number of Residues16
DetailsBINDING SITE FOR RESIDUE SAH B 401
ChainResidue
BSER140
BGLY166
BGLY168
BARG172
BASP189
BILE190
BALA191
BGLY216
BASP217
BALA218
BPHE239
BMET241
BHOH517
BHOH521
BHOH634
BHOH637

site_idAC8
Number of Residues10
DetailsBINDING SITE FOR RESIDUE 56D B 402
ChainResidue
BTRP99
BARG127
BMET240
BHIS243
BASP272
BPHE287
BPHE291
BHIS295
BFE403
BHOH721

site_idAC9
Number of Residues5
DetailsBINDING SITE FOR RESIDUE FE B 403
ChainResidue
BHIS243
BHIS295
B56D402
BHOH501
BHOH721

site_idBC1
Number of Residues12
DetailsBINDING SITE FOR RESIDUE HF2 B 404
ChainResidue
ALEU305
ALYS322
AALA324
AHF2404
AHOH553
BASP309
BPHE312
BCYS319
BVAL320
BLYS321
BLYS322
BHOH538

site_idBC2
Number of Residues3
DetailsBINDING SITE FOR RESIDUE CA B 405
ChainResidue
BGLY228
BPHE230
BHOH714

site_idBC3
Number of Residues4
DetailsBINDING SITE FOR RESIDUE CA B 406
ChainResidue
BGLY84
BPRO85
BPHE87
BASP88

site_idBC4
Number of Residues1
DetailsBINDING SITE FOR RESIDUE CA B 407
ChainResidue
BTYR134

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PDB entries from 2024-10-30

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