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4M6Q

Identification of Amides Derived From 1H-Pyrazolo[3,4-b]pyridine-5-carboxylic Acid as Potent Inhibitors of Human Nicotinamide Phosphoribosyltransferase (NAMPT)

Functional Information from GO Data
ChainGOidnamespacecontents
A0005125molecular_functioncytokine activity
A0005515molecular_functionprotein binding
A0005576cellular_componentextracellular region
A0005615cellular_componentextracellular space
A0005634cellular_componentnucleus
A0005737cellular_componentcytoplasm
A0005759cellular_componentmitochondrial matrix
A0005829cellular_componentcytosol
A0006741biological_processNADP+ biosynthetic process
A0006769biological_processnicotinamide metabolic process
A0006954biological_processinflammatory response
A0007165biological_processsignal transduction
A0007267biological_processcell-cell signaling
A0007623biological_processcircadian rhythm
A0008284biological_processpositive regulation of cell population proliferation
A0008286biological_processinsulin receptor signaling pathway
A0009435biological_processNAD+ biosynthetic process
A0010628biological_processpositive regulation of gene expression
A0016607cellular_componentnuclear speck
A0016740molecular_functiontransferase activity
A0016757molecular_functionglycosyltransferase activity
A0019363biological_processpyridine nucleotide biosynthetic process
A0030054cellular_componentcell junction
A0032922biological_processcircadian regulation of gene expression
A0034355biological_processNAD+ biosynthetic process via the salvage pathway
A0042802molecular_functionidentical protein binding
A0043123biological_processpositive regulation of canonical NF-kappaB signal transduction
A0045944biological_processpositive regulation of transcription by RNA polymerase II
A0047280molecular_functionnicotinamide phosphoribosyltransferase activity
A0048511biological_processrhythmic process
A0060612biological_processadipose tissue development
A0070062cellular_componentextracellular exosome
A0070374biological_processpositive regulation of ERK1 and ERK2 cascade
B0005125molecular_functioncytokine activity
B0005515molecular_functionprotein binding
B0005576cellular_componentextracellular region
B0005615cellular_componentextracellular space
B0005634cellular_componentnucleus
B0005737cellular_componentcytoplasm
B0005759cellular_componentmitochondrial matrix
B0005829cellular_componentcytosol
B0006741biological_processNADP+ biosynthetic process
B0006769biological_processnicotinamide metabolic process
B0006954biological_processinflammatory response
B0007165biological_processsignal transduction
B0007267biological_processcell-cell signaling
B0007623biological_processcircadian rhythm
B0008284biological_processpositive regulation of cell population proliferation
B0008286biological_processinsulin receptor signaling pathway
B0009435biological_processNAD+ biosynthetic process
B0010628biological_processpositive regulation of gene expression
B0016607cellular_componentnuclear speck
B0016740molecular_functiontransferase activity
B0016757molecular_functionglycosyltransferase activity
B0019363biological_processpyridine nucleotide biosynthetic process
B0030054cellular_componentcell junction
B0032922biological_processcircadian regulation of gene expression
B0034355biological_processNAD+ biosynthetic process via the salvage pathway
B0042802molecular_functionidentical protein binding
B0043123biological_processpositive regulation of canonical NF-kappaB signal transduction
B0045944biological_processpositive regulation of transcription by RNA polymerase II
B0047280molecular_functionnicotinamide phosphoribosyltransferase activity
B0048511biological_processrhythmic process
B0060612biological_processadipose tissue development
B0070062cellular_componentextracellular exosome
B0070374biological_processpositive regulation of ERK1 and ERK2 cascade
Functional Information from PDB Data
site_idAC1
Number of Residues27
DetailsBINDING SITE FOR RESIDUE 20T A 601
ChainResidue
ATYR188
AALA244
ASER275
AILE309
AARG311
AASP313
AGLY353
AGLY383
AGLY384
APO4603
AHOH708
AHIS191
AHOH711
AHOH756
AHOH792
AHOH810
BASP16
BTYR18
BARG392
BPOP602
APHE193
AARG196
AGLY217
AASP219
ATYR240
ASER241
AVAL242

site_idAC2
Number of Residues11
DetailsBINDING SITE FOR RESIDUE POP A 602
ChainResidue
AARG40
AARG392
ASER398
ALYS400
AHOH742
AHOH778
AHOH821
AHOH827
BARG196
B20T601
BPO4603

site_idAC3
Number of Residues9
DetailsBINDING SITE FOR RESIDUE PO4 A 603
ChainResidue
AARG196
AGLU246
AHIS247
AARG311
A20T601
AHOH708
AHOH823
BTYR18
BPOP602

site_idAC4
Number of Residues26
DetailsBINDING SITE FOR RESIDUE 20T B 601
ChainResidue
AASP16
ATYR18
AARG392
APOP602
AHOH742
AHOH821
BTYR188
BHIS191
BPHE193
BARG196
BGLY217
BASP219
BTYR240
BSER241
BVAL242
BALA244
BSER275
BILE309
BARG311
BASP313
BILE351
BGLY353
BGLY383
BGLY384
BPO4603
BHOH823

site_idAC5
Number of Residues10
DetailsBINDING SITE FOR RESIDUE POP B 602
ChainResidue
AARG196
A20T601
APO4603
AHOH708
BARG40
BARG392
BSER398
BLYS400
BLYS423
BHOH772

site_idAC6
Number of Residues9
DetailsBINDING SITE FOR RESIDUE PO4 B 603
ChainResidue
ATYR18
APOP602
AHOH736
BARG196
BGLU246
BHIS247
BARG311
BASP313
B20T601

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues18
DetailsBinding site: {}
ChainResidueDetails

site_idSWS_FT_FI2
Number of Residues2
DetailsModified residue: {"description":"Phosphotyrosine","evidences":[{"source":"PubMed","id":"15592455","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails

site_idSWS_FT_FI3
Number of Residues2
DetailsModified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"23186163","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails

238895

PDB entries from 2025-07-16

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