Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

4M53

Gamma subunit of the translation initiation factor 2 from Sulfolobus solfataricus in complex with GDPCP

Replaces: 3SJY

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000049	molecular_function	tRNA binding
A	0000166	molecular_function	nucleotide binding
A	0001731	biological_process	formation of translation preinitiation complex
A	0003743	molecular_function	translation initiation factor activity
A	0003746	molecular_function	translation elongation factor activity
A	0003924	molecular_function	GTPase activity
A	0005515	molecular_function	protein binding
A	0005525	molecular_function	GTP binding
A	0006412	biological_process	translation
A	0006413	biological_process	translational initiation
A	0006414	biological_process	translational elongation
A	0016787	molecular_function	hydrolase activity
A	0046872	molecular_function	metal ion binding

Functional Information from PDB Data

site_id	AC1
Number of Residues	6
Details	BINDING SITE FOR RESIDUE BME A 501

Chain	Residue
A	THR34
A	SER35
A	LYS36
A	TYR51
A	ARG219
A	HOH837

site_id	AC2
Number of Residues	7
Details	BINDING SITE FOR RESIDUE FMT A 502

Chain	Residue
A	HOH670
A	HOH680
A	HOH698
A	HOH1119
A	ALA342
A	LYS343
A	ARG404

site_id	AC3
Number of Residues	7
Details	BINDING SITE FOR RESIDUE FMT A 503

Chain	Residue
A	TYR206
A	ARG207
A	ASP208
A	GLN211
A	ILE243
A	HOH676
A	HOH753

site_id	AC4
Number of Residues	5
Details	BINDING SITE FOR RESIDUE FMT A 504

Chain	Residue
A	THR204
A	PRO205
A	ARG207
A	HOH617
A	HOH996

site_id	AC5
Number of Residues	7
Details	BINDING SITE FOR RESIDUE FMT A 505

Chain	Residue
A	LEU105
A	ILE139
A	SER360
A	VAL361
A	GLY362
A	HOH721
A	HOH723

site_id	AC6
Number of Residues	5
Details	BINDING SITE FOR RESIDUE FMT A 506

Chain	Residue
A	LYS64
A	TYR68
A	LEU86
A	HOH692
A	HOH949

site_id	AC7
Number of Residues	7
Details	BINDING SITE FOR RESIDUE FMT A 507

Chain	Residue
A	LYS347
A	VAL348
A	ASP349
A	ARG399
A	ILE401
A	HOH1045
A	HOH1185

site_id	AC8
Number of Residues	3
Details	BINDING SITE FOR RESIDUE FMT A 508

Chain	Residue
A	THR365
A	HOH794
A	HOH960

site_id	AC9
Number of Residues	5
Details	BINDING SITE FOR RESIDUE FMT A 509

Chain	Residue
A	GLN251
A	GLU252
A	GLU344
A	MET345
A	HOH686

site_id	BC1
Number of Residues	6
Details	BINDING SITE FOR RESIDUE FMT A 510

Chain	Residue
A	LEU312
A	SER364
A	THR365
A	HOH607
A	HOH651
A	HOH1229

site_id	BC2
Number of Residues	6
Details	BINDING SITE FOR RESIDUE FMT A 511

Chain	Residue
A	ARG130
A	HOH756
A	HOH757
A	HOH968
A	HOH1172
A	HOH1244

site_id	BC3
Number of Residues	10
Details	BINDING SITE FOR RESIDUE FMT A 512

Chain	Residue
A	ASP152
A	VAL153
A	HIS187
A	PRO324
A	LEU326
A	GCP525
A	HOH623
A	HOH661
A	HOH744
A	HOH758

site_id	BC4
Number of Residues	5
Details	BINDING SITE FOR RESIDUE FMT A 513

Chain	Residue
A	THR366
A	LEU367
A	ARG383
A	ARG384
A	HOH1079

site_id	BC5
Number of Residues	4
Details	BINDING SITE FOR RESIDUE FMT A 514

Chain	Residue
A	TRP3
A	ASN55
A	PRO72
A	FMT517

site_id	BC6
Number of Residues	4
Details	BINDING SITE FOR RESIDUE FMT A 515

Chain	Residue
A	PRO125
A	GLU252
A	FMT522
A	HOH639

site_id	BC7
Number of Residues	4
Details	BINDING SITE FOR RESIDUE FMT A 516

Chain	Residue
A	ARG280
A	GLY282
A	ASP283
A	GCP526

site_id	BC8
Number of Residues	5
Details	BINDING SITE FOR RESIDUE FMT A 517

Chain	Residue
A	ARG88
A	FMT514
A	HOH655
A	HOH849
A	HOH1014

site_id	BC9
Number of Residues	8
Details	BINDING SITE FOR RESIDUE FMT A 518

Chain	Residue
A	TRP327
A	LEU382
A	HOH830
A	HOH845
A	HOH1200
A	SER155
A	LYS156
A	GLU157

site_id	CC1
Number of Residues	5
Details	BINDING SITE FOR RESIDUE FMT A 519

Chain	Residue
A	ILE32
A	ALA52
A	GLU53
A	HOH923
A	HOH1150

site_id	CC2
Number of Residues	7
Details	BINDING SITE FOR RESIDUE FMT A 520

Chain	Residue
A	LYS212
A	GLN244
A	TRP389
A	SER390
A	HOH973
A	HOH1022
A	HOH1067

site_id	CC3
Number of Residues	5
Details	BINDING SITE FOR RESIDUE FMT A 521

Chain	Residue
A	THR30
A	GLY31
A	HOH658
A	HOH765
A	HOH1103

site_id	CC4
Number of Residues	5
Details	BINDING SITE FOR RESIDUE FMT A 522

Chain	Residue
A	PRO127
A	FMT515
A	HOH613
A	HOH667
A	HOH1216

site_id	CC5
Number of Residues	5
Details	BINDING SITE FOR RESIDUE FMT A 523

Chain	Residue
A	ASN121
A	HOH629
A	HOH858
A	HOH1125
A	HOH1183

site_id	CC6
Number of Residues	8
Details	BINDING SITE FOR RESIDUE FMT A 524

Chain	Residue
A	MET101
A	ALA102
A	MET358
A	SER398
A	TRP405
A	ARG406
A	HOH725
A	HOH988

site_id	CC7
Number of Residues	32
Details	BINDING SITE FOR RESIDUE GCP A 525

Chain	Residue
A	VAL18
A	ASP19
A	HIS20
A	GLY21
A	LYS22
A	THR23
A	THR24
A	GLY96
A	ASN149
A	LYS150
A	ASP152
A	VAL153
A	SER184
A	ALA185
A	LEU186
A	FMT512
A	MG527
A	HOH602
A	HOH618
A	HOH625
A	HOH629
A	HOH645
A	HOH673
A	HOH744
A	HOH816
A	HOH866
A	HOH889
A	HOH1096
A	HOH1108
A	HOH1190
A	HOH1202
A	HOH1253

site_id	CC8
Number of Residues	21
Details	BINDING SITE FOR RESIDUE GCP A 526

Chain	Residue
A	LYS36
A	PHE221
A	VAL223
A	LYS234
A	SER278
A	ILE279
A	ARG280
A	GLY282
A	ALA296
A	GLY298
A	FMT516
A	HOH911
A	HOH917
A	HOH994
A	HOH1013
A	HOH1056
A	HOH1070
A	HOH1201
A	HOH1210
A	HOH1211
A	HOH1217

site_id	CC9
Number of Residues	5
Details	BINDING SITE FOR RESIDUE MG A 527

Chain	Residue
A	THR23
A	GCP525
A	HOH602
A	HOH673
A	HOH1202

site_id	DC1
Number of Residues	6
Details	BINDING SITE FOR RESIDUE NA A 528

Chain	Residue
A	THR54
A	THR70
A	HOH655
A	HOH658
A	HOH685
A	HOH1103

site_id	DC2
Number of Residues	6
Details	BINDING SITE FOR RESIDUE NA A 529

Chain	Residue
A	VAL323
A	HOH623
A	HOH661
A	HOH682
A	HOH905
A	HOH1163

site_id	DC3
Number of Residues	7
Details	BINDING SITE FOR RESIDUE NA A 530

Chain	Residue
A	MET111
A	NA536
A	HOH611
A	HOH648
A	HOH693
A	HOH735
A	HOH818

site_id	DC4
Number of Residues	8
Details	BINDING SITE FOR RESIDUE NA A 531

Chain	Residue
A	NA534
A	NA535
A	HOH743
A	HOH746
A	HOH851
A	HOH859
A	HOH877
A	HOH1193

site_id	DC5
Number of Residues	5
Details	BINDING SITE FOR RESIDUE NA A 532

Chain	Residue
A	GLU66
A	TYR68
A	ASP192
A	HOH737
A	HOH1192

site_id	DC6
Number of Residues	6
Details	BINDING SITE FOR RESIDUE NA A 533

Chain	Residue
A	VAL151
A	VAL154
A	TRP327
A	ASN328
A	HOH1199
A	HOH1200

site_id	DC7
Number of Residues	7
Details	BINDING SITE FOR RESIDUE NA A 534

Chain	Residue
A	NA531
A	HOH851
A	HOH877
A	HOH888
A	HOH906
A	HOH1002
A	HOH1244

site_id	DC8
Number of Residues	7
Details	BINDING SITE FOR RESIDUE NA A 535

Chain	Residue
A	GLN168
A	PHE169
A	LYS171
A	NA531
A	HOH746
A	HOH775
A	HOH1193

site_id	DC9
Number of Residues	7
Details	BINDING SITE FOR RESIDUE NA A 536

Chain	Residue
A	NA530
A	HOH648
A	HOH693
A	HOH708
A	HOH735
A	HOH838
A	HOH860

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	7
Details	Region: {"description":"G1","evidences":[{"source":"HAMAP-Rule","id":"MF_00119","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI2
Number of Residues	3
Details	Region: {"description":"G3","evidences":[{"source":"HAMAP-Rule","id":"MF_00119","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI3
Number of Residues	3
Details	Region: {"description":"G4","evidences":[{"source":"HAMAP-Rule","id":"MF_00119","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI4
Number of Residues	2
Details	Region: {"description":"G5","evidences":[{"source":"HAMAP-Rule","id":"MF_00119","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI5
Number of Residues	10
Details	Binding site: {"evidences":[{"source":"HAMAP-Rule","id":"MF_00119","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"25690901","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"4RCY","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4RD1","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI6
Number of Residues	1
Details	Binding site: {"evidences":[{"source":"HAMAP-Rule","id":"MF_00119","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"25690901","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"4RD1","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI7
Number of Residues	1
Details	Binding site: {"evidences":[{"source":"HAMAP-Rule","id":"MF_00119","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"16407071","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"25690901","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"2AHO","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI8
Number of Residues	4
Details	Binding site: {"evidences":[{"source":"UniProtKB","id":"Q8U082","evidenceCode":"ECO:0000250"},{"source":"HAMAP-Rule","id":"MF_00119","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)