Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

4M3P

Betaine-Homocysteine S-Methyltransferase from Homo sapiens complexed with Homocysteine

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0005634	cellular_component	nucleus
A	0005829	cellular_component	cytosol
A	0006479	biological_process	protein methylation
A	0006575	biological_process	modified amino acid metabolic process
A	0006577	biological_process	amino-acid betaine metabolic process
A	0006579	biological_process	amino-acid betaine catabolic process
A	0008168	molecular_function	methyltransferase activity
A	0008172	molecular_function	S-methyltransferase activity
A	0008270	molecular_function	zinc ion binding
A	0009086	biological_process	methionine biosynthetic process
A	0016740	molecular_function	transferase activity
A	0032259	biological_process	methylation
A	0046500	biological_process	S-adenosylmethionine metabolic process
A	0046872	molecular_function	metal ion binding
A	0047150	molecular_function	betaine-homocysteine S-methyltransferase activity
A	0050666	biological_process	obsolete regulation of homocysteine metabolic process
A	0070062	cellular_component	extracellular exosome
A	0071266	biological_process	'de novo' L-methionine biosynthetic process
A	0071267	biological_process	L-methionine salvage
B	0005634	cellular_component	nucleus
B	0005829	cellular_component	cytosol
B	0006479	biological_process	protein methylation
B	0006575	biological_process	modified amino acid metabolic process
B	0006577	biological_process	amino-acid betaine metabolic process
B	0006579	biological_process	amino-acid betaine catabolic process
B	0008168	molecular_function	methyltransferase activity
B	0008172	molecular_function	S-methyltransferase activity
B	0008270	molecular_function	zinc ion binding
B	0009086	biological_process	methionine biosynthetic process
B	0016740	molecular_function	transferase activity
B	0032259	biological_process	methylation
B	0046500	biological_process	S-adenosylmethionine metabolic process
B	0046872	molecular_function	metal ion binding
B	0047150	molecular_function	betaine-homocysteine S-methyltransferase activity
B	0050666	biological_process	obsolete regulation of homocysteine metabolic process
B	0070062	cellular_component	extracellular exosome
B	0071266	biological_process	'de novo' L-methionine biosynthetic process
B	0071267	biological_process	L-methionine salvage
C	0005634	cellular_component	nucleus
C	0005829	cellular_component	cytosol
C	0006479	biological_process	protein methylation
C	0006575	biological_process	modified amino acid metabolic process
C	0006577	biological_process	amino-acid betaine metabolic process
C	0006579	biological_process	amino-acid betaine catabolic process
C	0008168	molecular_function	methyltransferase activity
C	0008172	molecular_function	S-methyltransferase activity
C	0008270	molecular_function	zinc ion binding
C	0009086	biological_process	methionine biosynthetic process
C	0016740	molecular_function	transferase activity
C	0032259	biological_process	methylation
C	0046500	biological_process	S-adenosylmethionine metabolic process
C	0046872	molecular_function	metal ion binding
C	0047150	molecular_function	betaine-homocysteine S-methyltransferase activity
C	0050666	biological_process	obsolete regulation of homocysteine metabolic process
C	0070062	cellular_component	extracellular exosome
C	0071266	biological_process	'de novo' L-methionine biosynthetic process
C	0071267	biological_process	L-methionine salvage
D	0005634	cellular_component	nucleus
D	0005829	cellular_component	cytosol
D	0006479	biological_process	protein methylation
D	0006575	biological_process	modified amino acid metabolic process
D	0006577	biological_process	amino-acid betaine metabolic process
D	0006579	biological_process	amino-acid betaine catabolic process
D	0008168	molecular_function	methyltransferase activity
D	0008172	molecular_function	S-methyltransferase activity
D	0008270	molecular_function	zinc ion binding
D	0009086	biological_process	methionine biosynthetic process
D	0016740	molecular_function	transferase activity
D	0032259	biological_process	methylation
D	0046500	biological_process	S-adenosylmethionine metabolic process
D	0046872	molecular_function	metal ion binding
D	0047150	molecular_function	betaine-homocysteine S-methyltransferase activity
D	0050666	biological_process	obsolete regulation of homocysteine metabolic process
D	0070062	cellular_component	extracellular exosome
D	0071266	biological_process	'de novo' L-methionine biosynthetic process
D	0071267	biological_process	L-methionine salvage

Functional Information from PDB Data

site_id	AC1
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN A 701

Chain	Residue
A	CYS217
A	CYS299
A	CYS300
A	HCS703

site_id	AC2
Number of Residues	7
Details	BINDING SITE FOR RESIDUE K A 702

Chain	Residue
A	HOH825
A	HOH945
A	ASP26
A	GLY27
A	GLN72
A	GLN247
A	GLY298

site_id	AC3
Number of Residues	11
Details	BINDING SITE FOR RESIDUE HCS A 703

Chain	Residue
A	GLY27
A	PHE29
A	VAL30
A	GLN72
A	GLU159
A	TYR160
A	CYS299
A	ZN701
A	HOH808
A	HOH825
A	HOH928

site_id	AC4
Number of Residues	12
Details	BINDING SITE FOR RESIDUE SRT B 501

Chain	Residue
A	GLU54
A	ARG57
B	ARG57
B	ARG61
B	HOH617
B	HOH626
B	HOH717
C	LYS150
C	LYS151
C	ASN152
C	HOH626
C	HOH780

site_id	AC5
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN B 502

Chain	Residue
B	CYS217
B	CYS299
B	CYS300
B	HCS504

site_id	AC6
Number of Residues	7
Details	BINDING SITE FOR RESIDUE K B 503

Chain	Residue
B	ASP26
B	GLY27
B	GLN72
B	GLN247
B	GLY298
B	HOH701
B	HOH737

site_id	AC7
Number of Residues	11
Details	BINDING SITE FOR RESIDUE HCS B 504

Chain	Residue
B	GLY27
B	GLY28
B	PHE29
B	VAL30
B	GLN72
B	GLU159
B	TYR160
B	CYS299
B	ZN502
B	HOH642
B	HOH701

site_id	AC8
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN C 501

Chain	Residue
C	CYS217
C	CYS299
C	CYS300
C	HCS503

site_id	AC9
Number of Residues	7
Details	BINDING SITE FOR RESIDUE K C 502

Chain	Residue
C	ASP26
C	GLY27
C	GLN72
C	GLN247
C	GLY298
C	HOH634
C	HOH658

site_id	BC1
Number of Residues	11
Details	BINDING SITE FOR RESIDUE HCS C 503

Chain	Residue
C	GLY27
C	GLY28
C	PHE29
C	VAL30
C	GLN72
C	GLU159
C	CYS299
C	ZN501
C	HOH628
C	HOH658
C	HOH759

site_id	BC2
Number of Residues	10
Details	BINDING SITE FOR RESIDUE SRT D 501

Chain	Residue
A	LYS150
A	LYS151
A	ASN152
A	HOH822
A	HOH877
A	HOH881
D	ARG57
D	ARG61
D	HOH611
D	HOH625

site_id	BC3
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN D 502

Chain	Residue
D	CYS217
D	CYS299
D	CYS300
D	HCS504

site_id	BC4
Number of Residues	6
Details	BINDING SITE FOR RESIDUE K D 503

Chain	Residue
D	ASP26
D	GLY27
D	GLN72
D	GLN247
D	GLY298
D	HOH684

site_id	BC5
Number of Residues	11
Details	BINDING SITE FOR RESIDUE HCS D 504

Chain	Residue
D	GLY28
D	PHE29
D	VAL30
D	GLN72
D	GLU159
D	TYR160
D	CYS299
D	ZN502
D	HOH622
D	HOH684
D	GLY27

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	12
Details	Binding site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU00333","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"12220488","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1LT8","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI2
Number of Residues	19
Details	Modified residue: {"description":"N6-succinyllysine","evidences":[{"source":"UniProtKB","id":"O35490","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

site_id	SWS_FT_FI3
Number of Residues	4
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"UniProtKB","id":"O09171","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)